{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:19:01Z","timestamp":1774563541136,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study assessed the effects of treatment with fluticasone in children younger than 2 years old with recurrent wheezing and risk factors of developing asthma. This double-blind placebo-controlled study randomized children to receive fluticasone (125 \u03bcg; n = 14) or placebo (n = 12) twice daily for 6 months. Pulmonary function was assessed at the beginning and end, and parents filled out a daily diary recording respiratory symptoms, need for rescue medication, and emergency care. The SD score of maximum flow at functional residual capacity was \u22120.74 \u00b1 0.6 at the beginning and 0.44 \u00b1 1 at the end for the fluticasone group (p = 0.001), and \u22120.79 \u00b1 0.3 at the beginning and \u22120.78 \u00b1 1.4 at the end for the placebo group (p = 0.97). A statistically significant difference (p = 0.02) was observed between treatments. The percentage of symptom-free days was 91.3 \u00b1 7% for fluticasone and 83.9 \u00b1 10% for placebo (p = 0.05). The number of respiratory exacerbations was 2.1 \u00b1 1.7 and 4.1 \u00b1 3 (p = 0.04), and the percentage of days on albuterol was 8.6 \u00b1 6% and 16.3 \u00b1 9% (p = 0.028). Treatment with fluticasone twice daily for 6 months improves pulmonary function and clinical outcomes in children with asthma younger than 2 years.<\/jats:p>","DOI":"10.1164\/rccm.200408-1088oc","type":"journal-article","created":{"date-parts":[[2005,3,7]],"date-time":"2005-03-07T18:38:14Z","timestamp":1110220694000},"page":"587-590","source":"Crossref","is-referenced-by-count":58,"title":["Fluticasone Improves Pulmonary Function in Children under 2 Years Old with Risk Factors for Asthma"],"prefix":"10.1093","volume":"171","author":[{"given":"Alejandro M.","family":"Teper","sequence":"first","affiliation":[{"name":"Respiratory Center, \u201cRicardo Gutierrez\u201d Children's Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos D.","family":"Kofman","sequence":"additional","affiliation":[{"name":"Respiratory Center, \u201cRicardo Gutierrez\u201d Children's Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela A.","family":"Szulman","sequence":"additional","affiliation":[{"name":"Respiratory Center, \u201cRicardo Gutierrez\u201d Children's Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago M.","family":"Vidaurreta","sequence":"additional","affiliation":[{"name":"Respiratory Center, \u201cRicardo Gutierrez\u201d Children's Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto F.","family":"Maffey","sequence":"additional","affiliation":[{"name":"Respiratory Center, \u201cRicardo Gutierrez\u201d Children's Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,3,15]]},"reference":[{"key":"2026032606195047800_BIB1","first-page":"133","volume-title":"N Engl J 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