{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:57:51Z","timestamp":1787018271701,"version":"build-2736575974"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rationale: Atrial overdrive pacing markedly improved sleep-disordered breathing in a recent study. Objectives: Using a single-blind, randomized, crossover design, we aimed to reproduce these findings and investigate the possible underlying mechanisms. Methods: Twenty ambulatory patients with an implanted pacemaker or cardioverter defibrillator were studied by polysomnography on 3 consecutive nights in a randomized, single-blind, crossover study in which devices were programmed for nonpacing or for overdrive pacing at 7 or 15 beats\/minute faster than the mean nocturnal heart rate. Ventilation and biomarkers (urinary norepinephrine excretion, amino-terminal portion of the precursor of brain natriuretic peptide, or NT-proBNP, were also evaluated. Measurements and Main Results: Neither the primary endpoint apnea\u2013hypopnea index, nor the apnea index, oxygen desaturation, ventilation, or biomarkers were affected by the nocturnal atrial overdrive pacing. A small, clinically insignificant, rate-dependent reduction in the hypopnea index was evoked by pacing (nonpacing, 13.4 \u00b1 1.4; pacing 7, 12.9 \u00b1 1.4; pacing 15, 10.9 \u00b1 1.0; p &amp;lt; 0.01, analysis of variance). Conclusions: The lack of effect on the apnea\u2013hypopnea index means that atrial overdrive pacing is inappropriate for treating sleep-disordered breathing.<\/jats:p>","DOI":"10.1164\/rccm.200409-1258oc","type":"journal-article","created":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T20:25:54Z","timestamp":1109967954000},"page":"118-122","source":"Crossref","is-referenced-by-count":62,"title":["Atrial Overdrive Pacing in Patients with Sleep Apnea with Implanted Pacemaker"],"prefix":"10.1093","volume":"172","author":[{"given":"Lars","family":"Lu\u0308thje","sequence":"first","affiliation":[{"name":"Department of Cardiology and Pneumology, Georg-August-Universita\u0308t, Go\u0308ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Unterberg-Buchwald","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, Georg-August-Universita\u0308t, Go\u0308ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani","family":"Dajani","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, Georg-August-Universita\u0308t, Go\u0308ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Vollmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, Georg-August-Universita\u0308t, Go\u0308ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Hasenfu\u00df","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, Georg-August-Universita\u0308t, Go\u0308ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Andreas","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, Georg-August-Universita\u0308t, Go\u0308ttingen, 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