{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:06:16Z","timestamp":1774523176215,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Tumor hypoxia has both prognostic and therapeutic consequences for solid tumors. We developed a novel noninvasive technique, differential path-length spectroscopy (DPS), which allows the measurement of hypoxia-related parameters in the superficial microvasculature of tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to measure the microvascular oxygenation of histologically normal endobronchial mucosa and of neoplastic lesions during bronchoscopy using DPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty-four patients with known or suspected malignancies of the lung were studied. One hundred and five endobronchial lesions (38 histologically normal, 37 metaplastic\/mild dysplastic lesions, and 30 invasive carcinomas) were detected by white and\/or autofluorescence bronchoscopy and measured using DPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed that bronchial tumors are characterized by a lower blood oxygen saturation and a higher blood content than normal mucosa. No differences were observed between normal and metaplastic\/mild dysplastic mucosa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DPS is a new optical technique allowing the noninvasive study of endobronchial tumor hypoxia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200501-046oc","type":"journal-article","created":{"date-parts":[[2005,2,11]],"date-time":"2005-02-11T20:24:19Z","timestamp":1108153459000},"page":"1178-1184","source":"Crossref","is-referenced-by-count":46,"title":["Measurement of Hypoxia-related Parameters in Bronchial Mucosa by Use of Optical Spectroscopy"],"prefix":"10.1093","volume":"171","author":[{"given":"Martin P. L.","family":"Bard","sequence":"first","affiliation":[{"name":"Department of Respiratory Diseases, Center for Optical Diagnostics and Therapy; Departments of Radiation Oncology and Statistics, Erasmus Medical Centre Rotterdam; and Departments of Pathology and Respiratory Diseases, Sint Franciscus Hospital, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjen","family":"Amelink","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, Center for Optical Diagnostics and Therapy; Departments of Radiation Oncology and Statistics, Erasmus Medical Centre Rotterdam; and Departments of Pathology and Respiratory Diseases, Sint Franciscus Hospital, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent Noordhoek","family":"Hegt","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, Center for Optical Diagnostics and Therapy; Departments of Radiation Oncology and Statistics, Erasmus Medical Centre Rotterdam; and Departments of Pathology and Respiratory Diseases, Sint Franciscus Hospital, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfried J.","family":"Graveland","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, Center for Optical Diagnostics and Therapy; Departments of Radiation Oncology and Statistics, Erasmus Medical Centre Rotterdam; and Departments of Pathology and Respiratory Diseases, Sint Franciscus Hospital, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henricus J. C. M.","family":"Sterenborg","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, Center for Optical Diagnostics and Therapy; Departments of Radiation Oncology and Statistics, Erasmus Medical Centre Rotterdam; and Departments of Pathology and Respiratory Diseases, Sint Franciscus Hospital, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk C.","family":"Hoogsteden","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, Center for Optical Diagnostics and Therapy; Departments of Radiation Oncology and Statistics, Erasmus Medical Centre Rotterdam; and Departments of Pathology and Respiratory Diseases, Sint Franciscus Hospital, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim G. J. 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