{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:35:06Z","timestamp":1788845706707,"version":"build-2803163510"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rationale: Oxidant stress may increase the severity of respiratory distress syndrome (RDS) after premature birth by altering vasoreactivity and increasing lung edema, but the acute effects of superoxide dismutase (SOD) treatment on gas exchange, lung compliance (CL), and pulmonary vascular resistance in premature animals with RDS are unknown. Objective: We studied the effects of intratracheal recombinant human SOD treatment (rhSOD) on gas exchange, CL, and pulmonary hemodynamics in 46 premature lambs with RDS. Methods: After C-section delivery, lambs were randomly assigned to treatment with SOD (2.5\u201310 mg\/kg) with or without inhaled nitric oxide (iNO, 5 ppm), and mechanically ventilated for 4 hours. At the end of the study, pressure\u2013volume curves and wet\u2013dry lung weights were measured to assess CL and edema, respectively. Main Results: Despite an initial rise in PaO2, PaO2 in control animals progressively declined over the 4-hour treatment period (PaO2 = 25.0 \u00b1 7.5 mm Hg at 4 hours). In comparison with control animals, early treatment with SOD at 5 and 10 mg\/kg improved PaO2 at 4 hours (167 \u00b1 44 and 269 \u00b1 33 mm Hg, respectively; p &amp;lt; 0.05 vs. control), but did not decrease lung edema or improve CL. In contrast, late treatment with SOD did not improve PaO2. Treatment with iNO increased PaO2 (196 \u00b1 22 vs. 25 \u00b1 8 mm Hg, control animals; p &amp;lt; 0.01), but the response to iNO was not augmented by combined therapy (SOD + iNO). After 4 hours of ventilation with FIO2 = 1.00, rhSOD treatment lowered pulmonary vascular resistance compared with control animals. Conclusions: Early intratracheal rhSOD treatment improves oxygenation in premature lambs with RDS and prevents the development of pulmonary hypertension.<\/jats:p>","DOI":"10.1164\/rccm.200501-146oc","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T20:45:39Z","timestamp":1118349939000},"page":"745-749","source":"Crossref","is-referenced-by-count":24,"title":["Superoxide Dismutase Improves Gas Exchange and Pulmonary Hemodynamics in Premature Lambs"],"prefix":"10.1093","volume":"172","author":[{"given":"John P.","family":"Kinsella","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Pediatric Heart-Lung Center, Sections of Neonatology, and Pulmonary and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado; and Department of Pediatrics and Cardiopulmonary Research Institute, Winthrop University Hospital, State University of New York at Stony Brook, Mineola, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Heart-Lung Center, Sections of Neonatology, and Pulmonary and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado; and Department of Pediatrics and Cardiopulmonary Research Institute, Winthrop University Hospital, State University of New York at Stony Brook, Mineola, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Heart-Lung Center, Sections of Neonatology, and Pulmonary and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado; and Department of Pediatrics and Cardiopulmonary Research Institute, Winthrop University Hospital, State University of New York at Stony Brook, Mineola, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Abman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Heart-Lung Center, Sections of Neonatology, and Pulmonary and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado; and Department of Pediatrics and Cardiopulmonary Research Institute, Winthrop University Hospital, State University of New York at Stony Brook, Mineola, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,9,15]]},"reference":[{"key":"2026032606043852400_BIB1","first-page":"457","volume-title":"Pediatr Res","year":"1997"},{"key":"2026032606043852400_BIB2","first-page":"699","volume-title":"J Appl Physiol","year":"1979"},{"key":"2026032606043852400_BIB3","first-page":"169","volume-title":"J Appl Physiol","year":"1983"},{"key":"2026032606043852400_BIB4","first-page":"443","volume-title":"J Pediatr","year":"1983"},{"key":"2026032606043852400_BIB5","first-page":"265","volume-title":"Pediatr Res","year":"1995"},{"key":"2026032606043852400_BIB6","first-page":"224","volume-title":"Pediatr Res","year":"1985"},{"key":"2026032606043852400_BIB7"},{"key":"2026032606043852400_BIB8","first-page":"677","volume-title":"Am Rev Respir Dis","year":"1988"},{"key":"2026032606043852400_BIB9","first-page":"L64","volume-title":"Am J Physiol","year":"1999"},{"key":"2026032606043852400_BIB10","first-page":"57","volume-title":"Am J Respir Crit Care Med","year":"2003"},{"key":"2026032606043852400_BIB11","first-page":"402","volume-title":"Pediatr Res","year":"1994"},{"key":"2026032606043852400_BIB12","first-page":"2234","volume-title":"J Appl Physiol","year":"1993"},{"key":"2026032606043852400_BIB13","first-page":"L903","volume-title":"Am J Physiol","year":"1997"},{"key":"2026032606043852400_BIB14","first-page":"834","volume-title":"Am J Respir Crit Care Med","year":"2001"},{"key":"2026032606043852400_BIB15","first-page":"811","volume-title":"Pediatrics","year":"1996"},{"key":"2026032606043852400_BIB16","first-page":"399","volume-title":"N Engl J Med","year":"1993"},{"key":"2026032606043852400_BIB17"},{"key":"2026032606043852400_BIB18","first-page":"370","volume-title":"J Clin Invest","year":"1981"},{"key":"2026032606043852400_BIB19","first-page":"402","volume-title":"Pediatr Res","year":"1994"},{"key":"2026032606043852400_BIB20","first-page":"469","volume-title":"Pediatrics","year":"2003"},{"key":"2026032606043852400_BIB21","first-page":"436","volume-title":"Am J Respir Cell Mol Biol","year":"2001"},{"key":"2026032606043852400_BIB22","first-page":"655","volume-title":"J Biol Chem","year":"1995"},{"key":"2026032606043852400_BIB23","first-page":"14492","volume-title":"Proc Natl Acad Sci USA","year":"1996"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/172\/6\/745\/67497660\/ajrccm_172_6_745.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/172\/6\/745\/67497660\/ajrccm_172_6_745.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:04:41Z","timestamp":1774519481000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/172\/6\/745\/8538103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":23,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,9,15]]},"published-print":{"date-parts":[[2005,9,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.200501-146oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,9]]},"published":{"date-parts":[[2005,9]]}}}