{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:01:56Z","timestamp":1774522916537,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>The role of the patent ductus arteriosus in the development of chronic lung disease in surfactant-treated premature newborns remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the effects of ductus ligation on cardiopulmonary function and lung histopathology in premature primates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Baboons were delivered at 125 d, (term = 185 d) treated with surfactant, and ventilated for 14 d. Serial echocardiograms and pulmonary function tests were performed. Animals were randomized to ligation (n = 12) or no ligation (controls, n = 13) on Day 6 of life. Necropsy was performed on Day 14.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with nonligated control animals, ligated animals had lower pulmonary-to-systemic flow ratios, higher systemic blood pressures, and improved indices of right and left ventricular performance. The ligated animals tended to have better compliance and ventilation indices for the last 3 d of the study. There were no differences between the groups in proinflammatory tracheal cytokines (interleukin [IL] 6 and IL-8), static lung compliance, or lung histology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although a persistent patent ductus arteriosus results in diminished cardiac function and increased ventilatory requirements at the end of the second week of life, ligation on Day 6 had no measurable effect on the histologic evolution of chronic lung injury in this 14-d baboon model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200502-230oc","type":"journal-article","created":{"date-parts":[[2005,9,22]],"date-time":"2005-09-22T20:34:31Z","timestamp":1127421271000},"page":"1569-1574","source":"Crossref","is-referenced-by-count":46,"title":["Effect of Ductus Ligation on Cardiopulmonary Function in Premature Baboons"],"prefix":"10.1093","volume":"172","author":[{"given":"Donald C.","family":"McCurnin","sequence":"first","affiliation":[{"name":"Southwest Foundation for Biomedical Research; Departments of Pediatrics, Pathology, Obstetrics-Gynecology, and Cardiothoracic Surgery, University of Texas Health Science Center; Wilford Hall Medical Center, San Antonio; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas; and Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley A.","family":"Yoder","sequence":"additional","affiliation":[{"name":"Southwest Foundation for Biomedical Research; Departments of Pediatrics, Pathology, Obstetrics-Gynecology, and Cardiothoracic Surgery, University of Texas Health Science Center; Wilford Hall Medical Center, San Antonio; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas; and Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Coalson","sequence":"additional","affiliation":[{"name":"Southwest Foundation for Biomedical Research; Departments of Pediatrics, Pathology, Obstetrics-Gynecology, and Cardiothoracic Surgery, University of Texas Health Science Center; Wilford Hall Medical Center, San Antonio; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas; and Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Grubb","sequence":"additional","affiliation":[{"name":"Southwest Foundation for Biomedical Research; Departments of Pediatrics, Pathology, Obstetrics-Gynecology, and Cardiothoracic Surgery, University of Texas Health Science Center; Wilford Hall Medical Center, San Antonio; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas; and Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Kerecman","sequence":"additional","affiliation":[{"name":"Southwest Foundation for Biomedical Research; Departments of Pediatrics, Pathology, Obstetrics-Gynecology, and Cardiothoracic Surgery, University of Texas Health Science Center; Wilford Hall Medical Center, San Antonio; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas; and Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kupferschmid","sequence":"additional","affiliation":[{"name":"Southwest Foundation for Biomedical Research; Departments of Pediatrics, Pathology, Obstetrics-Gynecology, and Cardiothoracic Surgery, University of Texas Health Science Center; Wilford Hall Medical Center, San Antonio; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas; and Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Breuer","sequence":"additional","affiliation":[{"name":"Southwest Foundation for Biomedical Research; Departments of Pediatrics, Pathology, Obstetrics-Gynecology, and Cardiothoracic Surgery, University of Texas Health Science Center; Wilford Hall Medical Center, San Antonio; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas; and Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Siler-Khodr","sequence":"additional","affiliation":[{"name":"Southwest Foundation for Biomedical Research; Departments of Pediatrics, Pathology, Obstetrics-Gynecology, and Cardiothoracic Surgery, University of Texas Health Science Center; Wilford Hall Medical Center, San Antonio; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas; and Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip W.","family":"Shaul","sequence":"additional","affiliation":[{"name":"Southwest Foundation for Biomedical Research; Departments of Pediatrics, Pathology, 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