{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:04:17Z","timestamp":1793387057679,"version":"4.5.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>The effect of early life wheezing on respiratory function and continued symptoms through adolescence has not been fully described. Using data from a population-based birth cohort in Tucson, Arizona, we previously described four phenotypes based on the occurrence of wheezing lower respiratory illnesses before age 3 yr and active wheeze at age 6 yr: never wheezers (n = 425), transient early wheezers (n = 164), persistent wheezers (n = 113), and late-onset wheezers (n = 124).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We sought to determine the prognosis for these phenotypes, with reference to lung function and symptoms, through adolescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Current wheeze was assessed by questionnaire, lung function was measured by conventional spirometry, and atopy was determined by skin prick tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of atopy and wheeze by age 16 yr was similar for never and transient wheezers and for persistent and late-onset wheezers. Both transient early, and persistent wheezers had significantly lower FEF25\u201375 (\u2013259 ml\/s, p &amp;lt; 0.001, and \u2013260 ml\/s, p = 0.001, respectively), FEV1 (\u201375 ml, p = 0.02, and \u201387 ml, p = 0.03, respectively), and FEV1:FVC ratio (\u20131.9%, p = 0.002, and \u20132.5%, p = 0.001, respectively) through age 16 yr compared with never wheezers. Late-onset wheezers had levels of lung function similar to those of never wheezers through age 16 yr. There was no significant change in lung function among subjects with any of the four phenotypes, relative to their peers, from age 6 to 16 yr.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patterns of wheezing prevalence and levels of lung function are established by age 6 yr and do not appear to change significantly by age 16 yr in children who start having asthmalike symptoms during the preschool years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200504-525oc","type":"journal-article","created":{"date-parts":[[2005,8,18]],"date-time":"2005-08-18T20:45:00Z","timestamp":1124397900000},"page":"1253-1258","source":"Crossref","is-referenced-by-count":560,"title":["Outcome of Asthma and Wheezing in the First 6 Years of Life"],"prefix":"10.1093","volume":"172","author":[{"given":"Wayne J.","family":"Morgan","sequence":"first","affiliation":[{"name":"Arizona Respiratory Center and Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona; and National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra A.","family":"Stern","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona; and National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane L.","family":"Sherrill","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona; and National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Guerra","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona; and National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharine J.","family":"Holberg","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona; and National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa W.","family":"Guilbert","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona; and National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn M.","family":"Taussig","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona; and National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L.","family":"Wright","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona; and National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando D.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona; and National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,11,15]]},"reference":[{"key":"2026032606105587000_BIB1","first-page":"1473","volume-title":"N Engl J Med","year":"2003"},{"key":"2026032606105587000_BIB2"},{"key":"2026032606105587000_BIB3","first-page":"189","volume-title":"J Allergy Clin Immunol","year":"2002"},{"key":"2026032606105587000_BIB4","first-page":"1414","volume-title":"N Engl J Med","year":"2003"},{"key":"2026032606105587000_BIB5","first-page":"133","volume-title":"N Engl J Med","year":"1995"},{"key":"2026032606105587000_BIB6"},{"key":"2026032606105587000_BIB7","first-page":"1219","volume-title":"Am J Epidemiol","year":"1989"},{"key":"2026032606105587000_BIB8","first-page":"1232","volume-title":"Am J Epidemiol","year":"1989"},{"key":"2026032606105587000_BIB9","first-page":"541","volume-title":"Lancet","year":"1999"},{"key":"2026032606105587000_BIB10","first-page":"1563","volume-title":"Clin Exp Allergy","year":"2004"},{"key":"2026032606105587000_BIB11","first-page":"2349","volume-title":"Stat Med","year":"1997"},{"key":"2026032606105587000_BIB12","first-page":"127","volume-title":"Organ Res Methods","year":"2004"},{"key":"2026032606105587000_BIB13","first-page":"S208","volume-title":"Am J Respir Crit Care Med","year":"1996"},{"key":"2026032606105587000_BIB14","first-page":"1054","volume-title":"N Engl J Med","year":"2000"},{"key":"2026032606105587000_BIB15","first-page":"51","volume-title":"Clin Exp Allergy","year":"2002"},{"key":"2026032606105587000_BIB16","first-page":"28","volume-title":"J Allergy Clin Immunol","year":"1999"},{"key":"2026032606105587000_BIB17","first-page":"397","volume-title":"Pediatr Pulmonol","year":"1997"},{"key":"2026032606105587000_BIB18","first-page":"419","volume-title":"Pediatr Pulmonol","year":"2001"},{"key":"2026032606105587000_BIB19","first-page":"1027","volume-title":"Clin Exp Allergy","year":"1997"},{"key":"2026032606105587000_BIB20","first-page":"1904","volume-title":"Lancet","year":"2002"},{"key":"2026032606105587000_BIB21","first-page":"921","volume-title":"Am J Respir Crit Care Med","year":"2004"},{"key":"2026032606105587000_BIB22","first-page":"150","volume-title":"Am J Respir Crit Care Med","year":"1999"},{"key":"2026032606105587000_BIB23","first-page":"1830","volume-title":"Am J Respir Crit Care Med","year":"1999"},{"key":"2026032606105587000_BIB24","first-page":"925","volume-title":"Thorax","year":"2004"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/172\/10\/1253\/67487306\/ajrccm_172_10_1253.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/172\/10\/1253\/67487306\/ajrccm_172_10_1253.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:11:03Z","timestamp":1774519863000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/172\/10\/1253\/8538228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":24,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2005,11,15]]},"published-print":{"date-parts":[[2005,11,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.200504-525oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,11]]},"published":{"date-parts":[[2005,11]]}}}