{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:16:55Z","timestamp":1789431415993,"version":"build-2803163510"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hemorrhagic shock followed by resuscitation (HSR) commonly triggers an inflammatory response that leads to acute respiratory distress syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>HSR exacerbates mechanical stress\u2013induced lung injury by rendering the lung more susceptible to ventilator-induced lung injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats were subjected to HSR, and were randomized into an HSR + high tidal volume and zero positive end-expiratory pressure (PEEP) or a HSR + low tidal volume with 5 cm H2O PEEP. A sham-operated rat + high tidal volume and zero PEEP served as a control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HSR increased susceptibility to ventilator-induced lung injury as evidenced by an increase in lung elastance and the wet\/dry ratio and a reduction in PaO2 as compared with the other groups. The lung injury observed in the HSR + high tidal volume group was associated with a higher level of interleukin 6 in the lung and blood, increased epithelial cell apoptosis in the kidney and small intestine villi, and a tendency toward high levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatinine in plasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HSR priming renders the lung and kidney more susceptible to mechanical ventilation\u2013induced organ injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200507-1178oc","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T21:14:37Z","timestamp":1146172477000},"page":"178-186","source":"Crossref","is-referenced-by-count":29,"title":["Ischemia and Reperfusion Increases Susceptibility to Ventilator-induced Lung Injury in Rats"],"prefix":"10.1093","volume":"174","author":[{"given":"Ettore","family":"Crimi","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine, University of Toronto; Interdepartmental Division of Critical Care Medicine, University of Toronto; Departments of Anaesthesiology and Surgery, University of Toronto; and Department of Critical Care Medicine, St. Michael's Hospital, Toronto, Ontario, Canada; Departments of Anesthesiology and Critical Care Medicine, University of Eastern Piedmont, Novara; and Sezione di Anestesiologia e Rianimazione, Dipartimento di discipline Medico-Chirurgiche, Universit\u00e0 di Torino, Ospedale S. Giovanni Battista, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine, University of Toronto; Interdepartmental Division of Critical Care Medicine, University of Toronto; Departments of Anaesthesiology and Surgery, University of Toronto; and Department of Critical Care Medicine, St. Michael's Hospital, Toronto, Ontario, Canada; Departments of Anesthesiology and Critical Care Medicine, University of Eastern Piedmont, Novara; and Sezione di Anestesiologia e Rianimazione, Dipartimento di discipline Medico-Chirurgiche, Universit\u00e0 di Torino, Ospedale S. Giovanni Battista, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin N. N.","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine, University of Toronto; Interdepartmental Division of Critical Care Medicine, University of Toronto; Departments of Anaesthesiology and Surgery, University of Toronto; and Department of Critical Care Medicine, St. Michael's Hospital, Toronto, Ontario, Canada; Departments of Anesthesiology and Critical Care Medicine, University of Eastern Piedmont, Novara; and Sezione di Anestesiologia e Rianimazione, Dipartimento di discipline Medico-Chirurgiche, Universit\u00e0 di Torino, Ospedale S. Giovanni Battista, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo Del","family":"Sorbo","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine, University of Toronto; Interdepartmental Division of Critical Care Medicine, University of Toronto; Departments of Anaesthesiology and Surgery, University of Toronto; and Department of Critical Care Medicine, St. Michael's Hospital, Toronto, Ontario, Canada; Departments of Anesthesiology and Critical Care Medicine, University of Eastern Piedmont, Novara; and Sezione di Anestesiologia e Rianimazione, Dipartimento di discipline Medico-Chirurgiche, Universit\u00e0 di Torino, Ospedale S. Giovanni Battista, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.Marco","family":"Ranieri","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine, University of Toronto; Interdepartmental Division of Critical Care Medicine, University of Toronto; Departments of Anaesthesiology and Surgery, University of Toronto; and Department of Critical Care Medicine, St. Michael's Hospital, Toronto, Ontario, Canada; Departments of Anesthesiology and Critical Care Medicine, University of Eastern Piedmont, Novara; and Sezione di Anestesiologia e Rianimazione, Dipartimento di discipline Medico-Chirurgiche, Universit\u00e0 di Torino, Ospedale S. 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