{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:43:50Z","timestamp":1789901030467,"version":"4.0.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Light chain deposition disease (LCDD) is a rare disorder that very uncommonly affects the lung. We report three cases of severe cystic pulmonary LCDD leading to lung transplantation. Such a presentation has never been previously reported. The three patients present with a progressive obstructive pulmonary pattern associated with numerous cysts diffusely distributed in both lungs. The disease was histologically characterized by non\u2013amyloid amorphous deposits in the alveolar walls, the small airways and the vessels. It was associated with emphysematous-like changes and small airway dilation. Monotypic \u03ba light chain fixation was demonstrated on the abnormal deposits and along the basement membranes. Electron microscopy revealed coarsely granular electron-dense deposits in the same localizations. Mild extrapulmonary deposits were found in salivary glands in one patient. No immunoproliferative disorder was identified. We conclude that LCDD may primarily affect the lung, present as a pulmonary cystic disorder, and lead to severe respiratory insufficiency.<\/jats:p>","DOI":"10.1164\/rccm.200510-1620cr","type":"journal-article","created":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T20:58:41Z","timestamp":1136581121000},"page":"777-780","source":"Crossref","is-referenced-by-count":137,"title":["Pulmonary Cystic Disorder Related to Light Chain Deposition Disease"],"prefix":"10.1093","volume":"173","author":[{"given":"Magali","family":"Colombat","sequence":"first","affiliation":[{"name":"Service d'Anatomie Pathologique and Service de Pneumologie\u2013H\u00f4pital Beaujon, Clichy; Service de Pneumologie\u2013H\u00f4pital Foch, Suresnes; Service d'Anatomie Pathologique\u2013H\u00f4pital Saint-Louis, Service de M\u00e9decine Interne\u2013Groupe Hospitalier Piti\u00e9-Salp\u00e9tri\u00e8re, and Service d'Anatomie Pathologique\u2013H\u00f4pital Europ\u00e9en Georges Pompidou, Paris; Service de Radiologie and Service de Pneumologie\u2013H\u00f4pital Avicenne, Bobigny; and Service de Pneumologie\u2013H\u00f4pital Intercommunal, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Stern","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique and Service de Pneumologie\u2013H\u00f4pital Beaujon, Clichy; Service de Pneumologie\u2013H\u00f4pital Foch, Suresnes; Service d'Anatomie Pathologique\u2013H\u00f4pital Saint-Louis, Service de M\u00e9decine Interne\u2013Groupe Hospitalier Piti\u00e9-Salp\u00e9tri\u00e8re, and Service d'Anatomie Pathologique\u2013H\u00f4pital Europ\u00e9en Georges Pompidou, Paris; Service de Radiologie and Service de Pneumologie\u2013H\u00f4pital Avicenne, Bobigny; and Service de Pneumologie\u2013H\u00f4pital Intercommunal, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Groussard","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique and Service de Pneumologie\u2013H\u00f4pital Beaujon, Clichy; Service de Pneumologie\u2013H\u00f4pital Foch, Suresnes; Service d'Anatomie Pathologique\u2013H\u00f4pital Saint-Louis, Service de M\u00e9decine Interne\u2013Groupe Hospitalier Piti\u00e9-Salp\u00e9tri\u00e8re, and Service d'Anatomie Pathologique\u2013H\u00f4pital Europ\u00e9en Georges Pompidou, Paris; Service de Radiologie and Service de Pneumologie\u2013H\u00f4pital Avicenne, Bobigny; and Service de Pneumologie\u2013H\u00f4pital Intercommunal, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Droz","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique and Service de Pneumologie\u2013H\u00f4pital Beaujon, Clichy; Service de Pneumologie\u2013H\u00f4pital Foch, Suresnes; Service d'Anatomie Pathologique\u2013H\u00f4pital Saint-Louis, Service de M\u00e9decine Interne\u2013Groupe Hospitalier Piti\u00e9-Salp\u00e9tri\u00e8re, and Service d'Anatomie Pathologique\u2013H\u00f4pital Europ\u00e9en Georges Pompidou, Paris; Service de Radiologie and Service de Pneumologie\u2013H\u00f4pital Avicenne, Bobigny; and Service de Pneumologie\u2013H\u00f4pital Intercommunal, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Brauner","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique and Service de Pneumologie\u2013H\u00f4pital Beaujon, Clichy; Service de Pneumologie\u2013H\u00f4pital Foch, Suresnes; Service d'Anatomie Pathologique\u2013H\u00f4pital Saint-Louis, Service de M\u00e9decine Interne\u2013Groupe Hospitalier Piti\u00e9-Salp\u00e9tri\u00e8re, and Service d'Anatomie Pathologique\u2013H\u00f4pital Europ\u00e9en Georges Pompidou, Paris; Service de Radiologie and Service de Pneumologie\u2013H\u00f4pital Avicenne, Bobigny; and Service de Pneumologie\u2013H\u00f4pital Intercommunal, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Valeyre","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique and Service de Pneumologie\u2013H\u00f4pital Beaujon, Clichy; Service de Pneumologie\u2013H\u00f4pital Foch, Suresnes; Service d'Anatomie Pathologique\u2013H\u00f4pital Saint-Louis, Service de M\u00e9decine Interne\u2013Groupe Hospitalier Piti\u00e9-Salp\u00e9tri\u00e8re, and Service d'Anatomie Pathologique\u2013H\u00f4pital Europ\u00e9en Georges Pompidou, Paris; Service de Radiologie and Service de Pneumologie\u2013H\u00f4pital Avicenne, Bobigny; and Service de Pneumologie\u2013H\u00f4pital Intercommunal, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Mal","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique and Service de Pneumologie\u2013H\u00f4pital Beaujon, Clichy; Service de Pneumologie\u2013H\u00f4pital Foch, Suresnes; Service d'Anatomie Pathologique\u2013H\u00f4pital Saint-Louis, Service de M\u00e9decine Interne\u2013Groupe Hospitalier Piti\u00e9-Salp\u00e9tri\u00e8re, and Service d'Anatomie Pathologique\u2013H\u00f4pital Europ\u00e9en Georges Pompidou, Paris; Service de Radiologie and Service de Pneumologie\u2013H\u00f4pital Avicenne, Bobigny; and Service de Pneumologie\u2013H\u00f4pital Intercommunal, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Taill\u00e9","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique and Service de Pneumologie\u2013H\u00f4pital Beaujon, Clichy; Service de Pneumologie\u2013H\u00f4pital Foch, Suresnes; Service d'Anatomie Pathologique\u2013H\u00f4pital Saint-Louis, Service de M\u00e9decine Interne\u2013Groupe Hospitalier Piti\u00e9-Salp\u00e9tri\u00e8re, and Service d'Anatomie Pathologique\u2013H\u00f4pital Europ\u00e9en Georges Pompidou, Paris; Service de Radiologie and Service de Pneumologie\u2013H\u00f4pital Avicenne, Bobigny; and Service de Pneumologie\u2013H\u00f4pital Intercommunal, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Monnet","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique and Service de Pneumologie\u2013H\u00f4pital Beaujon, Clichy; Service de Pneumologie\u2013H\u00f4pital Foch, Suresnes; Service d'Anatomie Pathologique\u2013H\u00f4pital Saint-Louis, Service de M\u00e9decine Interne\u2013Groupe Hospitalier Piti\u00e9-Salp\u00e9tri\u00e8re, and Service d'Anatomie Pathologique\u2013H\u00f4pital Europ\u00e9en Georges Pompidou, Paris; Service de Radiologie and Service de Pneumologie\u2013H\u00f4pital Avicenne, Bobigny; and Service de Pneumologie\u2013H\u00f4pital Intercommunal, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Fournier","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique and Service de Pneumologie\u2013H\u00f4pital Beaujon, Clichy; Service de Pneumologie\u2013H\u00f4pital Foch, Suresnes; Service d'Anatomie Pathologique\u2013H\u00f4pital Saint-Louis, Service de M\u00e9decine Interne\u2013Groupe Hospitalier Piti\u00e9-Salp\u00e9tri\u00e8re, and Service d'Anatomie Pathologique\u2013H\u00f4pital Europ\u00e9en Georges Pompidou, Paris; Service de Radiologie and Service de Pneumologie\u2013H\u00f4pital Avicenne, Bobigny; and Service de Pneumologie\u2013H\u00f4pital Intercommunal, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Herson","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique and Service de Pneumologie\u2013H\u00f4pital Beaujon, Clichy; Service de Pneumologie\u2013H\u00f4pital Foch, Suresnes; Service d'Anatomie Pathologique\u2013H\u00f4pital Saint-Louis, Service de M\u00e9decine Interne\u2013Groupe Hospitalier Piti\u00e9-Salp\u00e9tri\u00e8re, and Service d'Anatomie Pathologique\u2013H\u00f4pital Europ\u00e9en Georges Pompidou, Paris; Service de Radiologie and Service de Pneumologie\u2013H\u00f4pital Avicenne, Bobigny; and Service de Pneumologie\u2013H\u00f4pital Intercommunal, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Danel","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique and Service de Pneumologie\u2013H\u00f4pital Beaujon, Clichy; Service de Pneumologie\u2013H\u00f4pital Foch, Suresnes; Service d'Anatomie Pathologique\u2013H\u00f4pital Saint-Louis, Service de M\u00e9decine Interne\u2013Groupe Hospitalier Piti\u00e9-Salp\u00e9tri\u00e8re, and Service d'Anatomie Pathologique\u2013H\u00f4pital Europ\u00e9en Georges Pompidou, Paris; Service de Radiologie and Service de Pneumologie\u2013H\u00f4pital Avicenne, Bobigny; and Service de Pneumologie\u2013H\u00f4pital Intercommunal, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,4,1]]},"reference":[{"key":"2026040105525202900_BIB1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0002-9343(76)90440-X","volume":"60","year":"1976","journal-title":"Am J Med"},{"key":"2026040105525202900_BIB2"},{"key":"2026040105525202900_BIB3","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0889-8588(05)70123-4","volume":"13","year":"1999","journal-title":"Hematol Oncol Clin North Am"},{"key":"2026040105525202900_BIB4","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1681\/ASN.V1271558","volume":"12","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"2026040105525202900_BIB5"},{"key":"2026040105525202900_BIB6","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/00000478-198805000-00009","volume":"12","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"2026040105525202900_BIB7","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1309\/3GECPW2402F6V8EK","volume":"121","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"2026040105525202900_BIB8","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1097\/00000478-198712000-00010","volume":"11","year":"1987","journal-title":"Am J Surg Pathol"},{"key":"2026040105525202900_BIB9","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1046\/j.1365-2559.1998.00393.x","volume":"32","year":"1998","journal-title":"Histopathology"},{"key":"2026040105525202900_BIB10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1046\/j.1365-2141.2002.03781.x","volume":"119","year":"2002","journal-title":"Br J Haematol"},{"key":"2026040105525202900_BIB11","first-page":"1059","volume":"10","year":"1997","journal-title":"Mod Pathol"},{"key":"2026040105525202900_BIB12","first-page":"131","volume":"304","year":"1981","journal-title":"N Engl J Med"},{"key":"2026040105525202900_BIB13","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1148\/radiographics.22.suppl_1.g02oc13s185","volume":"22","year":"2002","journal-title":"Radiographics"},{"key":"2026040105525202900_BIB14","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1148\/rg.243045005","volume":"24","year":"2004","journal-title":"Radiographics"},{"key":"2026040105525202900_BIB15","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1183\/13993003\/erj.9.7.1569","volume":"9","year":"1996","journal-title":"Eur Respir J"},{"key":"2026040105525202900_BIB16","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1148\/radiology.212.2.r99au05567","volume":"212","year":"1999","journal-title":"Radiology"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/173\/7\/777\/67395827\/ajrccm_173_7_777.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/173\/7\/777\/67395827\/ajrccm_173_7_777.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:52:59Z","timestamp":1775037179000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/173\/7\/777\/8528115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,1]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2006,4,1]]},"published-print":{"date-parts":[[2006,4,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.200510-1620cr","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,4]]},"published":{"date-parts":[[2006,4,1]]}}}