{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:18:25Z","timestamp":1790918305600,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>We have previously reported an association between reduced maternal vitamin E intake during pregnancy and wheezing in 2-yr-old children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess whether maternal nutrient intake during pregnancy is associated with asthma-related outcomes in children aged 5 yr.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A longitudinal cohort study of 1,861 children born to women recruited during pregnancy and followed up at 5 yr.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Maternal nutrient status was assessed by a food frequency questionnaire and plasma levels. Respiratory and food frequency questionnaires were completed at 5 yr and children were invited for measurement of spirometry and skin-prick testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Results<\/jats:title>\n                    <jats:p>Symptom and food frequency questionnaire data were available for 1,253 and 1,120 children, respectively; 700 children were skin prick tested, and FEV1 was measured in 478 and exhaled nitric oxide in 167 children. In 5-yr-old children, maternal vitamin E intake during pregnancy was negatively associated with wheeze in previous year (odds ratio per intake quintile, 0.82; 95% confidence interval, 0.71\u20130.95), asthma ever (0.84, 0.72\u20130.98), asthma and wheeze in previous year (0.79, 0.65\u20130.95), and persistent wheezing (0.77, 0.63\u20130.93). Maternal plasma \u03b1-tocopherol during pregnancy was positively associated with post-bronchodilator FEV1 at 5 yr, with a 7-ml (95% confidence interval, 0\u201314; p = 0.04) increase in FEV1 per \u03bcg\/ml \u03b1-tocopherol. Maternal zinc intake during pregnancy was negatively associated with asthma ever (0.83, 0.71\u20130.78) and active asthma (0.72, 0.59\u20130.89). There were no associations between children's nutrient intake and respiratory outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maternal intake of foods containing vitamin E and zinc during pregnancy is associated with differences in the risks of developing childhood wheeze and asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200512-1946oc","type":"journal-article","created":{"date-parts":[[2006,6,8]],"date-time":"2006-06-08T21:29:14Z","timestamp":1149802154000},"page":"499-507","source":"Crossref","is-referenced-by-count":207,"title":["Low Maternal Vitamin E Intake during Pregnancy Is Associated with Asthma in 5-Year-Old Children"],"prefix":"10.1093","volume":"174","author":[{"given":"Graham","family":"Devereux","sequence":"first","affiliation":[{"name":"Departments of Environmental and Occupational Medicine and Child Health, University of Aberdeen, Aberdeen, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.","family":"Turner","sequence":"additional","affiliation":[{"name":"Departments of Environmental and Occupational Medicine and Child Health, University of Aberdeen, Aberdeen, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leone C. 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