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Infants hospitalized with bronchiolitis are at significantly increased risk for both recurrent wheezing and childhood asthma. To date, studies addressing the incidence of asthma after bronchiolitis severe enough to warrant hospitalization have focused almost exclusively on RSV, but a number of recent studies suggest that other respiratory pathogens, including RV, may contribute as well. It is not known whether viral bronchiolitis directly contributes to asthma causation or simply identifies infants at risk for subsequent wheezing, as from an atopic predisposition or preexisting abnormal lung function. Alternatively, the properties of the infecting virus may be important. Thus, many possible determinants exist that may contribute to the severity of bronchiolitis and the subsequent development of asthma. One such determinant is the potential involvement of genetic susceptibility loci to asthma after viral bronchiolitis, a critical area that is just beginning to be evaluated. By clarifying the roles of both host- (genetic) and virus- (environment) specific factors that contribute to the frequency and severity of viral LRTI, it may be possible to determine if severe LRTIs cause asthma, or if asthma susceptibility predisposes patients to severe LRTI in response to viral infection. Characterizing these relationships offers the potential of identifying at-risk hosts in whom preventing or delaying infection could alter the phenotypic expression of asthma.<\/jats:p>","DOI":"10.1164\/rccm.200603-435pp","type":"journal-article","created":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T21:39:46Z","timestamp":1161293986000},"page":"108-119","source":"Crossref","is-referenced-by-count":166,"title":["Bronchiolitis to Asthma"],"prefix":"10.1093","volume":"175","author":[{"given":"Anne Marie","family":"Singh","sequence":"first","affiliation":[{"name":"Departments of Medicine and Pediatrics, University of Wisconsin\u2013Madison, Madison, Wisconsin; and Departments of Pediatrics and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Moore","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pediatrics, University of Wisconsin\u2013Madison, Madison, Wisconsin; and Departments of Pediatrics and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Gern","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pediatrics, University of Wisconsin\u2013Madison, Madison, Wisconsin; and Departments of Pediatrics and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert F.","family":"Lemanske","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pediatrics, University of Wisconsin\u2013Madison, Madison, Wisconsin; and Departments of Pediatrics and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina V.","family":"Hartert","sequence":"additional","affiliation":[{"name":"Departments of Medicine 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