{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:45:31Z","timestamp":1774125931521,"version":"3.50.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The tuberculin skin test (TST) has low specificity. QuantiFERON-TB Gold (QFT-G) and T-SPOT.TB are based on interferon (IFN)-\u03b3 responses to Mycobacterium tuberculosis\u2013specific antigens. A novel in-tube format of QFT-G (QFT-GIT) offers logistical advantages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare TST, QFT-GIT, and T-SPOT.TB in bacillus Calmette-Gu\u00e9rin unvaccinated contacts and correlate results with measures of recent exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>When a supermarket employee with smear-positive tuberculosis had infected most close contacts, a contact investigation among more than 20,000 customers was performed. We recruited subjects randomly on the day of TST administration (n = 469) and subjects with TST of more than 0 mm on the day of TST reading (n = 316). QFT-GIT and T-SPOT.TB were performed. Demographic data and measures of exposure were collected. TST results were analyzed at a cutoff of 10 or 15 mm. Blood tests were interpreted following the manufacturers' criteria and by varying cutoff levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 785 study participants, TST results were associated with age, whereas positive IFN-\u03b3 responses were significantly associated with cumulative shopping time, most markedly for QFT-GIT. Among participants with a TST of 15 mm or greater, sensitivity of QFT-GIT and T-SPOT.TB was 42.2 and 51.3%, respectively. Interassay agreement was 89.6% (\u03ba = 0.59). By varying cutoff values, agreement between the IFN-\u03b3 assays was optimal at 93.6% (\u03ba = 0.71) using a cutoff of 0.20 IU\/ml for QFT-GIT and 13 spots for T-SPOT.TB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Blood test results were associated with exposure, whereas the TST was not. A possible lack of sensitivity of IFN-\u03b3 assays in detecting individuals with TST of 15 mm or greater, despite negative bacillus Calmette-Gu\u00e9rin vaccination status, warrants further investigation into alternative cutoff values.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200608-1099oc","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T21:25:01Z","timestamp":1166131501000},"page":"618-627","source":"Crossref","is-referenced-by-count":199,"title":["Comparison of Two Interferon-\u03b3 Assays and Tuberculin Skin Test for Tracing Tuberculosis Contacts"],"prefix":"10.1093","volume":"175","author":[{"given":"Sandra M.","family":"Arend","sequence":"first","affiliation":[{"name":"Leiden University Medical Center, Infectious Diseases, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven F. 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