{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:57:54Z","timestamp":1787018274055,"version":"build-2736575974"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Hypersensitivity pneumonitis (HP) is mediated by a Th1 immune response. Transcription factor GATA binding protein-3 (GATA-3) is believed to be a key regulator of Th2 differentiation and thus might play regulatory roles in the pathogenesis of hypersensitivity pneumonitis (HP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We examined the effect of GATA-3 overexpression on the development of HP in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Wild-type C57BL\/6 mice and GATA-3\u2013overexpressing mice of the same background were used in this study. HP was induced by repeated exposure to Saccharopolyspora rectivirgula, the causative antigen of farmer's lung.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Antigen exposure resulted in a marked inflammatory response with enhanced pulmonary expression of T-bet and the Th1 cytokine interferon (IFN)-\u03b3 in wild-type mice. The degree of pulmonary inflammation was much less severe in GATA-3\u2013overexpressing mice. The induction of T-bet and IFN-\u03b3 genes was suppressed, but a significant induction of Th2 cytokines, including IL-5 and IL-13, was observed in the lungs of GATA-3\u2013overexpressing mice after antigen exposure. Supplementation with recombinant IFN-\u03b3 enhanced lung inflammatory responses in GATA-3\u2013overexpressing mice to the level of wild-type mice. Because antigen-induced IFN-\u03b3 production predominantly occurred in CD4+ T cells, nude mice were transferred with CD4+ T cells from either wild-type or GATA-3\u2013overexpressing mice and subsequently exposed to antigen. Lung inflammatory responses were significantly lower in nude mice transferred with CD4+ T cells from GATA-3\u2013overexpressing mice than in those with wild-type CD4+ T cells, with a reduction of lung IFN-\u03b3 level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicate that overexpression of GATA-3 attenuates the development of HP by correcting the Th1-polarizing condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200612-1887oc","type":"journal-article","created":{"date-parts":[[2007,11,5]],"date-time":"2007-11-05T16:22:03Z","timestamp":1194279723000},"page":"1015-1025","source":"Crossref","is-referenced-by-count":25,"title":["Overexpression of GATA-3 Protects against the Development of Hypersensitivity Pneumonitis"],"prefix":"10.1093","volume":"176","author":[{"given":"Yosuke","family":"Matsuno","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigyou","family":"Yoh","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Institute of Clinical Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Morishima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Haraguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Kiwamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morio","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Hizawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,11,15]]},"reference":[{"key":"2026032102262744800_BIB1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00130832-200404000-00004","volume":"4","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"2026032102262744800_BIB2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/01.mcp.0000135675.95674.29","volume":"10","year":"2004","journal-title":"Curr Opin Pulm Med"},{"key":"2026032102262744800_BIB3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1165\/ajrcmb\/5.5.477","volume":"5","year":"1991","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032102262744800_BIB4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1165\/ajrcmb\/6.1.68","volume":"6","year":"1992","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032102262744800_BIB5","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1164\/ajrccm\/146.2.479","volume":"146","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"2026032102262744800_BIB6","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.4049\/jimmunol.169.7.3700","volume":"169","year":"2002","journal-title":"J Immunol"},{"key":"2026032102262744800_BIB7","first-page":"991","volume":"161","year":"1988","journal-title":"J Immunol"},{"key":"2026032102262744800_BIB8","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1172\/JCI119420","volume":"99","year":"1997","journal-title":"J Clin Invest"},{"key":"2026032102262744800_BIB9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0882-4010(92)90100-3","volume":"12","year":"1992","journal-title":"Microb Pathog"},{"key":"2026032102262744800_BIB10","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1165\/ajrcmb.19.5.3153","volume":"19","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032102262744800_BIB11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/cimm.1997.1107","volume":"177","year":"1997","journal-title":"Cell Immunol"},{"key":"2026032102262744800_BIB12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1183\/09031936.03.00291203","volume":"21","year":"2003","journal-title":"Eur Respir J"},{"key":"2026032102262744800_BIB13","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/383787a0","volume":"383","year":"1996","journal-title":"Nature"},{"key":"2026032102262744800_BIB14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0167-5699(95)80068-9","volume":"16","year":"1995","journal-title":"Immunol Today"},{"key":"2026032102262744800_BIB15","doi-asserted-by":"crossref","first-page":"21597","DOI":"10.1074\/jbc.272.34.21597","volume":"272","year":"1997","journal-title":"J Biol Chem"},{"key":"2026032102262744800_BIB16","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)80240-8","volume":"89","year":"1997","journal-title":"Cell"},{"key":"2026032102262744800_BIB17","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1074-7613(00)80671-8","volume":"9","year":"1998","journal-title":"Immunity"},{"key":"2026032102262744800_BIB18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1074-7613(03)00057-8","volume":"18","year":"2003","journal-title":"Immunity"},{"key":"2026032102262744800_BIB19","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.4049\/jimmunol.161.8.3817","volume":"161","year":"1998","journal-title":"J Immunol"},{"key":"2026032102262744800_BIB20","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1006\/clim.1999.4718","volume":"91","year":"1999","journal-title":"Clin Immunol"},{"key":"2026032102262744800_BIB21","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1073\/pnas.0308697100","volume":"101","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026032102262744800_BIB22","first-page":"A537","volume":"175","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032102262744800_BIB23","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1097\/01.ASN.0000086473.23379.25","volume":"14","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"2026032102262744800_BIB24","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.4049\/jimmunol.129.5.2160","volume":"129","year":"1982","journal-title":"J Immunol"},{"key":"2026032102262744800_BIB25","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1084\/jem.183.3.901","volume":"183","year":"1996","journal-title":"J Exp Med"},{"key":"2026032102262744800_BIB26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0091-6749(88)90907-4","volume":"81","year":"1988","journal-title":"J Allergy Clin Immunol"},{"key":"2026032102262744800_BIB27","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/eji.200324634","volume":"34","year":"2004","journal-title":"Eur J Immunol"},{"key":"2026032102262744800_BIB28","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2353\/ajpath.2006.051160","volume":"169","year":"2006","journal-title":"Am J Pathol"},{"key":"2026032102262744800_BIB29","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.imlet.2005.03.005","volume":"99","year":"2005","journal-title":"Immunol Lett"},{"key":"2026032102262744800_BIB30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1164\/rccm.200601-079OC","volume":"174","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032102262744800_BIB31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1165\/ajrcmb\/5.5.477","volume":"5","year":"1991","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032102262744800_BIB32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.192.1.105","volume":"192","year":"2000","journal-title":"J Exp Med"},{"key":"2026032102262744800_BIB33","doi-asserted-by":"crossref","first-page":"24548","DOI":"10.1074\/jbc.270.41.24548","volume":"270","year":"1995","journal-title":"J Biol Chem"},{"key":"2026032102262744800_BIB34","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.4049\/jimmunol.160.5.2343","volume":"160","year":"1998","journal-title":"J Immunol"},{"key":"2026032102262744800_BIB35","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.4049\/jimmunol.167.8.4414","volume":"167","year":"2001","journal-title":"J Immunol"},{"key":"2026032102262744800_BIB36","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.4049\/jimmunol.161.8.3822","volume":"161","year":"1998","journal-title":"J Immunol"},{"key":"2026032102262744800_BIB37","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1074-7613(00)80073-4","volume":"10","year":"1999","journal-title":"Immunity"},{"key":"2026032102262744800_BIB38","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","volume":"100","year":"2000","journal-title":"Cell"},{"key":"2026032102262744800_BIB39","doi-asserted-by":"crossref","first-page":"15137","DOI":"10.1073\/pnas.261570598","volume":"98","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026032102262744800_BIB40","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1084\/jem.20052165","volume":"203","year":"2006","journal-title":"J Exp Med"},{"key":"2026032102262744800_BIB41","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1365-2222.1992.tb02819.x","volume":"22","year":"1992","journal-title":"Clin Exp Allergy"},{"key":"2026032102262744800_BIB42","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1002\/eji.200425762","volume":"35","year":"2005","journal-title":"Eur J Immunol"},{"key":"2026032102262744800_BIB43","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.4049\/jimmunol.177.8.5258","volume":"177","year":"2006","journal-title":"J Immunol"},{"key":"2026032102262744800_BIB44","first-page":"3432","volume":"106","year":"2005","journal-title":"Blood"},{"key":"2026032102262744800_BIB45","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0008-8749(91)90354-E","volume":"136","year":"1991","journal-title":"Cell Immunol"},{"key":"2026032102262744800_BIB46","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1164\/ajrccm.149.5.7909706","volume":"149","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032102262744800_BIB47","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1164\/ajrccm.151.6.7767527","volume":"151","year":"1995","journal-title":"Am J Respir Crit Care Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/176\/10\/1015\/67332807\/ajrccm_176_10_1015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/176\/10\/1015\/67332807\/ajrccm_176_10_1015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:26:37Z","timestamp":1774074397000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/176\/10\/1015\/8518579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":47,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2007,11,15]]},"published-print":{"date-parts":[[2007,11,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.200612-1887oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2007,11]]},"published":{"date-parts":[[2007,11]]}}}