{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:14:53Z","timestamp":1774124093634,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Acute airway response, measured as cross-shift change in FEV1, to cotton dust may lead to subsequent chronic loss of lung function in exposed workers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore the association between the magnitude and frequency of cross-shift change and chronic loss of FEV1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four hundred eight cotton workers and 417 silk workers from Shanghai textile mills were observed prospectively for 20 years, with cross-shift measurements at baseline and follow-up surveys at approximate 5-year intervals. To account for repeated measures of 5-year change, generalized estimating equations were used to estimate the relationship between the magnitude of cross-shift change in FEV1 (\u0394FEV1) and subsequent 5-year annualized change. Linear regression models were used to examine the association between the number of drops in cross-shift FEV1 (\u0394FEV1 &amp;lt; 0) and annualized change over the entire study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Exposure to cotton dust was associated with a 10 ml\/year decrement in 5-year annualized FEV1 decline. In addition, every 10 ml in \u0394FEV1 drop was associated with an additional 1.5 ml\/year loss in annualized FEV1 decline. The association between the frequency of drops and annualized decline was stronger for cotton workers than for silk workers over the entire study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cotton workers had larger and more frequent drops, as well as excessive chronic declines in FEV1, than did silk workers. The magnitude and frequency of cross-shift drops were associated with chronic loss in FEV1 over the entire 20-year period examined.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200702-318oc","type":"journal-article","created":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T21:00:01Z","timestamp":1193950801000},"page":"316-320","source":"Crossref","is-referenced-by-count":23,"title":["Cross-shift Airway Responses and Long-Term Decline in FEV1 in Cotton Textile Workers"],"prefix":"10.1093","volume":"177","author":[{"given":"Xiaorong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Harvard School of Public Health, Boston, Massachusetts"},{"name":"Department of Community and Family Medicine, The Chinese University of Hong Kong School of Public Health, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Putuo District People\u2019s Hospital, Shanghai, China; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi-Xiong","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai Putuo District People\u2019s Hospital, Shanghai, China; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He-Lian","family":"Dai","sequence":"additional","affiliation":[{"name":"Shanghai Putuo District People\u2019s Hospital, Shanghai, China; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Qing","family":"Hang","sequence":"additional","affiliation":[{"name":"Shanghai Putuo District People\u2019s Hospital, Shanghai, China; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Eisen","sequence":"additional","affiliation":[{"name":"Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Harvard School of Public Health, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Harvard School of Public Health, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Christiani","sequence":"additional","affiliation":[{"name":"Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Harvard School of Public Health, Boston, Massachusetts"},{"name":"Pulmonary and Critical Care Unit, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, 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