{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:49:13Z","timestamp":1792759753749,"version":"4.5.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Severe and recurrent acute vascular rejection of the pulmonary allograft is an accepted major risk factor for obliterative bronchiolitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We assessed the role of lymphocytic bronchiolitis as a risk factor for bronchiolitis obliterans syndrome (BOS) and death after lung transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of 341 90-day survivors of lung transplant performed in 1995\u20132005 who underwent 1,770 transbronchial lung biopsy procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Transbronchial biopsies showed grade B0 (normal) (n = 501), B1 (minimal) (n = 762), B2 (mild) (n = 176), B3 (moderate) (n = 70), B4 (severe) (n = 4) lymphocytic bronchiolitis, and Bx (no bronchiolar tissue) (n = 75). A total of 182 transbronchial biopsies were ungraded (8 inadequate, 142 cytomegalovirus, 32 other diagnoses). Lung transplant recipients were grouped by highest B grade before diagnosis of BOS: B0 (n = 12), B1 (n = 166), B2 (n = 89), and B3\u2013B4 (n = 51). Twenty-three were unclassifiable. Cumulative incidence of BOS and death were dependent on highest B grade (Kaplan-Meier, P &amp;lt; 0.001, log-rank). Multivariable Cox proportional hazards analysis showed significant risks for BOS were highest B grade (relative risk [RR], 1.62; 95% confidence interval [CI], 1.31\u20132.00) (P &amp;lt; 0.001), longer ischemic time (RR, 1.00; CI, 1.00\u20131.00) (P &amp;lt; 0.05), and recent year of transplant (RR, 0.93; CI, 0.87\u20131.00) (P &amp;lt; 0.05), whereas risks for death were BOS as a time-dependent covariable (RR, 19.10; CI, 11.07\u201332.96) (P &amp;lt; 0.001) and highest B grade (RR, 1.36; CI, 1.07\u20131.72) (P &amp;lt; 0.05). Acute vascular rejection was not a significant risk factor in either model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Severity of lymphocytic bronchiolitis is associated with increased risk of BOS and death after lung transplantation independent of acute vascular rejection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200706-951oc","type":"journal-article","created":{"date-parts":[[2008,2,8]],"date-time":"2008-02-08T21:49:52Z","timestamp":1202507392000},"page":"1033-1040","source":"Crossref","is-referenced-by-count":175,"title":["Severity of Lymphocytic Bronchiolitis Predicts Long-Term Outcome after Lung Transplantation"],"prefix":"10.1093","volume":"177","author":[{"given":"Allan R.","family":"Glanville","sequence":"first","affiliation":[{"name":"The Lung Transplant Unit, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina L.","family":"Aboyoun","sequence":"additional","affiliation":[{"name":"The Lung Transplant Unit, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Havryk","sequence":"additional","affiliation":[{"name":"The Lung Transplant Unit, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall","family":"Plit","sequence":"additional","affiliation":[{"name":"The Lung Transplant Unit, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Rainer","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, St. Vincent\u2019s Hospital, Darlinghurst, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique A.","family":"Malouf","sequence":"additional","affiliation":[{"name":"The Lung Transplant Unit, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,5,1]]},"reference":[{"key":"2026032102495120700_BIB1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.healun.2007.06.003","volume":"26","year":"2007","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB2","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1164\/rccm.200201-003PP","volume":"166","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032102495120700_BIB3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1053-2498(02)00398-4","volume":"21","year":"2002","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB4","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1097\/00007890-198805000-00005","volume":"45","year":"1988","journal-title":"Transplantation"},{"key":"2026032102495120700_BIB5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00007890-199707270-00023","volume":"64","year":"1997","journal-title":"Transplantation"},{"key":"2026032102495120700_BIB6","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00000478-199305000-00008","volume":"17","year":"1993","journal-title":"Am J Surg Pathol"},{"key":"2026032102495120700_BIB7","first-page":"1200","volume":"15","year":"1996","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB8","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S1053-2498(99)00047-9","volume":"18","year":"1999","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB9","first-page":"1","volume":"15","year":"1996","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1164\/ajrccm.159.3.9607099","volume":"159","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032102495120700_BIB11","first-page":"S107","volume":"26","year":"2007","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB12","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1183\/09031936.03.00039003","volume":"22","year":"2003","journal-title":"Eur Respir J"},{"key":"2026032102495120700_BIB13","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1097\/00007890-199810150-00033","volume":"66","year":"1998","journal-title":"Transplantation"},{"key":"2026032102495120700_BIB14","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.healun.2006.03.011","volume":"25","year":"2006","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1445-5994.2006.01003.x","volume":"36","year":"2006","journal-title":"Intern Med J"},{"key":"2026032102495120700_BIB16","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1164\/ajrccm.164.3.2011152","volume":"164","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032102495120700_BIB17","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/S1053-2498(02)00442-4","volume":"21","year":"2002","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB18","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1164\/rccm.200302-165OC","volume":"170","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032102495120700_BIB19","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1164\/ajrccm\/136.5.1285","volume":"136","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"2026032102495120700_BIB20","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1097\/01.tp.0000202755.33883.61","volume":"81","year":"2006","journal-title":"Transplantation"},{"key":"2026032102495120700_BIB21","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.healun.2003.08.032","volume":"23","year":"2004","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB22","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.healun.2003.08.008","volume":"23","year":"2004","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB23","first-page":"126","volume":"9","year":"1996","journal-title":"Mod Pathol"},{"key":"2026032102495120700_BIB24","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1164\/rccm.200310-1405OC","volume":"170","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032102495120700_BIB25","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1164\/ajrccm.160.5.9808113","volume":"160","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032102495120700_BIB26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.healun.2003.09.042","volume":"24","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB27","first-page":"1255","volume":"17","year":"1998","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB28","first-page":"832","volume":"16","year":"1997","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB29","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.healun.2004.04.002","volume":"24","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.humpath.2005.01.022","volume":"36","year":"2005","journal-title":"Hum Pathol"},{"key":"2026032102495120700_BIB31","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/S0022-5223(19)34193-5","volume":"105","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026032102495120700_BIB32","first-page":"437","volume":"10","year":"1991","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB33","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s004280000386","volume":"438","year":"2001","journal-title":"Virchows Arch"},{"key":"2026032102495120700_BIB34","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.healun.2003.07.003","volume":"23","year":"2004","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB35","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.athoracsur.2006.03.070","volume":"82","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"2026032102495120700_BIB36","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1164\/rccm.2107009","volume":"165","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032102495120700_BIB37","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1378\/chest.92.3.547","volume":"92","year":"1987","journal-title":"Chest"},{"key":"2026032102495120700_BIB38","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1164\/ajrccm\/139.2.330","volume":"139","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"2026032102495120700_BIB39","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1097\/00007890-199457120-00014","volume":"57","year":"1994","journal-title":"Transplantation"},{"key":"2026032102495120700_BIB40","first-page":"432","volume":"119","year":"1995","journal-title":"Arch Pathol Lab Med"},{"key":"2026032102495120700_BIB41","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1034\/j.1600-6143.2001.001003228.x","volume":"1","year":"2001","journal-title":"Am J Transplant"},{"key":"2026032102495120700_BIB42","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1600-6143.2004.00650.x","volume":"5","year":"2005","journal-title":"Am J Transplant"},{"key":"2026032102495120700_BIB43","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0046-8177(94)90126-0","volume":"25","year":"1994","journal-title":"Hum Pathol"},{"key":"2026032102495120700_BIB44","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1034\/j.1600-6143.2003.00168.x","volume":"3","year":"2003","journal-title":"Am J Transplant"},{"key":"2026032102495120700_BIB45","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1164\/rccm.200608-1079OC","volume":"175","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032102495120700_BIB46","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.healun.2004.11.049","volume":"24","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB47","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1053-2498(02)00467-9","volume":"22","year":"2003","journal-title":"J Heart Lung Transplant"},{"key":"2026032102495120700_BIB48","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1016\/j.healun.2005.06.027","volume":"24","year":"2005","journal-title":"J Heart Lung Transplant"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/177\/9\/1033\/67329187\/ajrccm_177_9_1033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/177\/9\/1033\/67329187\/ajrccm_177_9_1033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:50:06Z","timestamp":1774075806000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/177\/9\/1033\/8518058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,1]]},"references-count":48,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2008,5,1]]},"published-print":{"date-parts":[[2008,5,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.200706-951oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,5]]},"published":{"date-parts":[[2008,5,1]]}}}