{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:38:54Z","timestamp":1774125534912,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>The development of lung cancer (LC) is accompanied by field changes in the airway mucosa that may have prognostic importance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare patients with prevalent LC to control subjects regarding their histologic dysplasia scores and chromosomal aneusomy as measured by fluorescence in situ hybridization (FISH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The most advanced bronchial histology lesion was assessed from each of 44 LC cases and 90 cancer-free control subjects using a four-color FISH probe set encompassing the chromosome 6 centromere, 5p15.2, 7p12 (epidermal growth factor receptor), and 8q24 v-myc myelocytomatosis viral oncogene homolog (MYC) sequences. Histology grades were coded as dysplasia (moderate or severe) or carcinoma in situ (CIS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>CIS was the highest histologic grade for 32 subjects, and dysplasia was the highest grade for 102 subjects (54 moderate, 48 severe). Chromosomal aneusomy was seen in 64% of the LC cases, but in only 31% of the control subjects (odds ratio [OR], 4.68; 95% confidence interval [CI]. 1.97\u201311.04). Among those with any level of dysplasia, the OR for positive FISH and LC was 2.28 (95% CI, 0.75\u20136.86). Among those with CIS, the OR for positive FISH and LC was 5.84 (95% CI, 1.31\u201326.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Chromosomal aneusomy is associated with LC. Prospective examination of aneusomy as a precursor lesion that predicts LC is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200708-1142oc","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T21:24:37Z","timestamp":1194470677000},"page":"342-347","source":"Crossref","is-referenced-by-count":35,"title":["Chromosomal Aneusomy in Bronchial High-Grade Lesions Is Associated with Invasive Lung Cancer"],"prefix":"10.1093","volume":"177","author":[{"given":"Steinn","family":"Jonsson","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado"},{"name":"Department of Medicine, University of Iceland Hospitals, Reykjavik, Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marileila","family":"Varella-Garcia","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"York E.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado"},{"name":"Pulmonary Division, Department of Medicine, Denver Veterans Affairs Medical Center, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly J.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Biostatistics, University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Byers","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Biostatistics, University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Braudrick","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Biostatistics, University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Porntip","family":"Kiatsimkul","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy C.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Department of Medicine, Presbyterian\/St. Luke\u2019s Health One Medical Center, Denver, 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