{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:15:04Z","timestamp":1791249304989,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Monge's disease is characterized by an excessive erythrocytosis, frequently associated with pulmonary hypertension, in high-altitude dwellers. It has a considerable impact on public health in high-altitude regions. A preliminary study demonstrated the efficiency of acetazolamide (Acz) (250 mg\/d for 3 wk) in reducing serum erythropoietin and hematocrit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Evaluate the efficacy and tolerance of a 6-month treatment with 250 mg Acz that could be chronically implemented and its effects on pulmonary artery pressure and cardiac function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A two-phase study was performed in patients (hematocrit \u2a7e 63%) from Cerro de Pasco, Peru (4,300 m). First phase: a double-blind, placebo-controlled study in 55 patients who received a single dose of either 250 mg Acz (n = 40) or placebo (n = 15) by daily oral administration for 12 weeks. Second phase (open label): after a 4-week washout period, all patients received 250 mg Acz for 12 weeks. Hematocrit, blood gases, clinical outcome, and pulmonary artery circulation were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>First phase: Acz decreased by 44% the number of polycythemic subjects (P = 0.02), decreased hematocrit from 69 to 64% (P &amp;lt; 0.001), and increased arterial O2 pressure from 42 to 45 mm Hg (P &amp;lt; 0.001). No severe adverse effect or hypokalemia was recorded. The second phase reproduced the effects observed during the first phase, without cumulative effects on hematocrit. A 4-week washout restored basal hematocrit. Only patients who received Acz for 6 months showed a clear reduction in pulmonary vascular resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acz reduces erythrocytosis and improves pulmonary circulation in Monge's disease without adverse effects. Its implementation as a chronic treatment for this disease appears efficient and safe.<\/jats:p>\n                    <jats:p>Clinical trial registered with www.clinicaltrials.gov (NCT00424970).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200802-196oc","type":"journal-article","created":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T21:57:30Z","timestamp":1207259850000},"page":"1370-1376","source":"Crossref","is-referenced-by-count":84,"title":["Acetazolamide for Monge's Disease"],"prefix":"10.1093","volume":"177","author":[{"given":"Jean-Paul","family":"Richalet","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris 13, Laboratoire \u201cR\u00e9ponses cellulaires et fonctionnelles \u00e0 l\u2019hypoxie\u2019\u2019, EA 2363, ARPE, UFR SMBH, Bobigny, France"},{"name":"AP-HP, H\u00f4pital Avicenne, Service de Physiologie et Explorations Fonctionnelles, Service de Pharmacie, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rivera-Ch","sequence":"additional","affiliation":[{"name":"Universidad Peruana Cayetano Heredia, Facultad de Ciencias y Filosof\u00eda, Dpto. de Ciencias Biol\u00f3gicas y Fisiol\u00f3gicas, Laboratorio de Fisiolog\u00eda Comparada, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Maignan","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris 13, Laboratoire \u201cR\u00e9ponses cellulaires et fonctionnelles \u00e0 l\u2019hypoxie\u2019\u2019, EA 2363, ARPE, UFR SMBH, Bobigny, France"},{"name":"CHU Grenoble, P\u00f4le Urgences, La Tronche, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Privat","sequence":"additional","affiliation":[{"name":"Universidad Peruana Cayetano Heredia, Facultad de Ciencias y Filosof\u00eda, Dpto. de Ciencias Biol\u00f3gicas y Fisiol\u00f3gicas, Laboratorio de 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