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Each subject was assigned model-based estimates of average PM10 during the 12 months preceding each health assessment and the difference was used as the exposure variable of interest (\u0394PM10). Analyses were stratified by symptom status at baseline and associations between \u0394PM10 and change in symptom status during follow-up were adjusted for important baseline characteristics, smoking status at follow-up, and season. We then estimated adjusted odds ratios for symptoms at follow-up and numbers of symptomatic cases prevented due to the observed reductions in PM10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Residential exposure to PM10 was lower in 2002 than in 1991 (mean decline 6.2 \u03bcg\/m3; SD = 3.9 \u03bcg\/m3). Estimated benefits (per 10,000 persons) attributable to the observed changes in PM10-levels were: 259 (95% confidence interval [CI]: 102\u2013416) fewer subjects with regular cough, 179 (95% CI, 30\u2013328) fewer subjects with chronic cough or phlegm and 137 (95% CI, 9\u2013266) fewer subjects with wheezing and breathlessness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Reductions in particle levels in Switzerland over the 11-year follow-up period had a beneficial effect on respiratory symptoms among adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200803-388oc","type":"journal-article","created":{"date-parts":[[2009,1,16]],"date-time":"2009-01-16T21:47:08Z","timestamp":1232142428000},"page":"579-587","source":"Crossref","is-referenced-by-count":93,"title":["Improvements in PM10 Exposure and Reduced Rates of Respiratory Symptoms in a Cohort of Swiss Adults (SAPALDIA)"],"prefix":"10.1093","volume":"179","author":[{"given":"Christian","family":"Schindler","sequence":"first","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Basel, Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Keidel","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Basel, Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret W.","family":"Gerbase","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, University Hospitals of Geneva, Geneva"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Zemp","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Basel, 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