{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:25:44Z","timestamp":1791228344733,"version":"4.1.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":5954,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000139","name":"US Environmental Protection Agency","doi-asserted-by":"publisher","award":["RD 83329301-0"],"award-info":[{"award-number":["RD 83329301-0"]}],"id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES-011961"],"award-info":[{"award-number":["ES-011961"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES-016347"],"award-info":[{"award-number":["ES-016347"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Epidemiologic studies implicate air pollutant exposure during pregnancy as a risk factor for wheezing in offspring. Ozone exposure is linked to exacerbations of wheezing in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine if maternal pulmonary exposure to traffic-related particles during pregnancy augments ozone\u2013induced airway hyperresponsiveness in offspring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>C57BL6 time-mated mice were given NIST SRM#1648 (particulate matter [PM]) 0.48 mg, saline vehicle, or no treatment by tracheal insufflation twice weekly for 3 weeks. PM exposure augmented maternal lung inflammation and placental TNF-\u03b1, Keratinocyte-derived cytokine (KC), and IL-6 (measured at gestation Day 18). After parturition, dams and litters were exposed to air or ozone 1 ppm 3 h\/d, every other day, thrice weekly for 4 weeks. Respiratory system resistance in pups was measured at baseline and after administration of nebulized methacholine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Ozone increased airway hyperresponsiveness, but the increase was greatest in pups born to PM-treated dams. Whole-lung TNF-\u03b1, IL-1\u03b2, KC, IL-6, and MCP-1 were increased in ozone\u2013treated pups, with the greatest increase in pups born to dams given PM. Airway epithelial mucous metaplasia estimated by periodic acid-Schiff Alcian blue staining was increased in ozone\u2013exposed pups born to PM-treated dams. Alveolar development, determined by morphometry, and airway smooth muscle bulk, estimated using \u03b1-actin histochemistry, were unaffected by prenatal or postnatal treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Maternal pulmonary exposure to PM during pregnancy augments placental cytokine expression and postnatal ozone\u2013induced pulmonary inflammatory cytokine responses and ozone\u2013induced airway hyperresponsiveness without altering airway structure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200901-0116oc","type":"journal-article","created":{"date-parts":[[2009,9,18]],"date-time":"2009-09-18T01:28:59Z","timestamp":1253237339000},"page":"1218-1226","source":"Crossref","is-referenced-by-count":33,"title":["Maternal Exposure to Particulate Matter Increases Postnatal Ozone-induced Airway Hyperreactivity in Juvenile Mice"],"prefix":"10.1093","volume":"180","author":[{"given":"Richard L.","family":"Auten","sequence":"first","affiliation":[{"name":"Neonatal Medicine, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin N.","family":"Potts","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine, Department of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Nicholas","family":"Mason","sequence":"additional","affiliation":[{"name":"Neonatal Medicine, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Fischer","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine, Department of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhchin","family":"Huang","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine, Department of Pediatrics, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Michael","family":"Foster","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine, Department of Pediatrics, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,15]]},"reference":[{"key":"2026032120021050100_BIB1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1136\/thorax.55.4.271","volume":"55","year":"2000","journal-title":"Thorax"},{"key":"2026032120021050100_BIB2","first-page":"60","volume":"59","year":"2004","journal-title":"Thorax"},{"key":"2026032120021050100_BIB3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1651-2227.2005.tb01938.x","volume":"94","year":"2005","journal-title":"Acta Paediatr"},{"key":"2026032120021050100_BIB4","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1289\/ehp.7673","volume":"113","year":"2005","journal-title":"Environ Health Perspect"},{"key":"2026032120021050100_BIB5","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1289\/ehp.10952","volume":"116","year":"2008","journal-title":"Environ Health Perspect"},{"key":"2026032120021050100_BIB6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/MCP.0b013e3282f1987a","volume":"14","year":"2008","journal-title":"Curr Opin Pulm Med"},{"key":"2026032120021050100_BIB7","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s10654-005-1048-1","volume":"20","year":"2005","journal-title":"Eur J Epidemiol"},{"key":"2026032120021050100_BIB8","first-page":"3","volume":"135","year":"2008","journal-title":"Res Rep Health Eff Inst"},{"key":"2026032120021050100_BIB9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1165\/rcmb.2007-0124OC","volume":"38","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032120021050100_BIB10","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1080\/15287390600974692","volume":"70","year":"2007","journal-title":"J Toxicol Environ Health A"},{"key":"2026032120021050100_BIB11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1164\/rccm.200311-1499OC","volume":"170","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032120021050100_BIB12","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1289\/ehp.8559","volume":"114","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2026032120021050100_BIB13","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1001\/jama.290.14.1859","volume":"290","year":"2003","journal-title":"JAMA"},{"key":"2026032120021050100_BIB14","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1289\/ehp.10497","volume":"116","year":"2008","journal-title":"Environ Health Perspect"},{"key":"2026032120021050100_BIB15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0041-008X(88)90256-6","volume":"96","year":"1988","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026032120021050100_BIB16","first-page":"A542","volume":"175","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032120021050100_BIB17","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1152\/jappl.2001.90.3.1111","volume":"90","year":"2001","journal-title":"J Appl Physiol"},{"key":"2026032120021050100_BIB18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1165\/rcmb.2003-0001OC","volume":"31","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032120021050100_BIB19","doi-asserted-by":"crossref","first-page":"L336","DOI":"10.1152\/ajplung.2001.281.2.L336","volume":"281","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026032120021050100_BIB20","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1126\/science.1108228","volume":"308","year":"2005","journal-title":"Science"},{"key":"2026032120021050100_BIB21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1164\/rccm.200605-662OC","volume":"176","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032120021050100_BIB22","doi-asserted-by":"crossref","first-page":"L1293","DOI":"10.1152\/ajplung.00140.2004","volume":"287","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026032120021050100_BIB23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/08958378.2000.11463215","volume":"12","year":"2000","journal-title":"Inhal Toxicol"},{"key":"2026032120021050100_BIB24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1165\/rcmb.2006-0116OC","volume":"36","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032120021050100_BIB25","doi-asserted-by":"crossref","first-page":"L337","DOI":"10.1152\/ajplung.00202.2003","volume":"286","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026032120021050100_BIB26","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1021\/tx960164m","volume":"10","year":"1997","journal-title":"Chem Res Toxicol"},{"key":"2026032120021050100_BIB27","doi-asserted-by":"crossref","first-page":"C357","DOI":"10.1152\/ajpcell.00365.2005","volume":"291","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026032120021050100_BIB28","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/00039896.1991.9937434","volume":"46","year":"1991","journal-title":"Arch Environ Health"},{"key":"2026032120021050100_BIB29","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1097\/00043764-199911000-00009","volume":"41","year":"1999","journal-title":"J Occup Environ Med"},{"key":"2026032120021050100_BIB30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/jech.58.1.11","volume":"58","year":"2004","journal-title":"J Epidemiol Community Health"},{"key":"2026032120021050100_BIB31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1289\/ehp.02110197","volume":"110","year":"2002","journal-title":"Environ Health Perspect"},{"key":"2026032120021050100_BIB32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/10937400601034563","volume":"10","year":"2007","journal-title":"J Toxicol Environ Health B Crit Rev"},{"key":"2026032120021050100_BIB33","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.taap.2008.01.040","volume":"229","year":"2008","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026032120021050100_BIB34","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1080\/08958370701353528","volume":"19","year":"2007","journal-title":"Inhal Toxicol"},{"key":"2026032120021050100_BIB35","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1189\/jlb.1008587","volume":"86","year":"2009","journal-title":"J Leukoc Biol"},{"key":"2026032120021050100_BIB36","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/15476910802481765","volume":"5","year":"2008","journal-title":"J Immunotoxicol"},{"key":"2026032120021050100_BIB37","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/toxsci\/kfn253","volume":"107","year":"2009","journal-title":"Toxicol Sci"},{"key":"2026032120021050100_BIB38","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1152\/japplphysiol.00381.2001","volume":"92","year":"2002","journal-title":"J Appl Physiol"},{"key":"2026032120021050100_BIB39","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1164\/ajrccm.149.1.8111607","volume":"149","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032120021050100_BIB40","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1152\/japplphysiol.01253.2006","volume":"103","year":"2007","journal-title":"J Appl Physiol"},{"key":"2026032120021050100_BIB41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1465-9921-7-24","volume":"7","year":"2006","journal-title":"Respir Res"},{"key":"2026032120021050100_BIB42","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0041-008X(03)00218-7","volume":"191","year":"2003","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026032120021050100_BIB43","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1152\/jappl.1999.87.4.1272","volume":"87","year":"1999","journal-title":"J Appl Physiol"},{"key":"2026032120021050100_BIB44","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1152\/japplphysiol.00924.2003","volume":"96","year":"2004","journal-title":"J Appl Physiol"},{"key":"2026032120021050100_BIB45","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1378\/chest.07-2404","volume":"133","year":"2008","journal-title":"Chest"},{"key":"2026032120021050100_BIB46","first-page":"1236","volume":"54","year":"1983","journal-title":"J Appl Physiol"},{"key":"2026032120021050100_BIB47","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1183\/09031936.98.12020288","volume":"12","year":"1998","journal-title":"Eur Respir J"},{"key":"2026032120021050100_BIB48","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1080\/00984100290071432","volume":"65","year":"2002","journal-title":"J Toxicol Environ Health A"},{"key":"2026032120021050100_BIB49","doi-asserted-by":"crossref","first-page":"L627","DOI":"10.1152\/ajplung.00377.2004","volume":"289","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026032120021050100_BIB50","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1513\/pats.200701-023AW","volume":"4","year":"2007","journal-title":"Proc Am Thorac Soc"},{"key":"2026032120021050100_BIB51","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1465-9921-8-56","volume":"8","year":"2007","journal-title":"Respir Res"},{"key":"2026032120021050100_BIB52","first-page":"1","volume":"61","year":"2008","journal-title":"Am J Reprod Immunol"},{"key":"2026032120021050100_BIB53","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1097\/01.AOG.0000178750.84837.ed","volume":"106","year":"2005","journal-title":"Obstet Gynecol"},{"key":"2026032120021050100_BIB54","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/01.AOG.0000114980.40445.83","volume":"103","year":"2004","journal-title":"Obstet Gynecol"},{"key":"2026032120021050100_BIB55","doi-asserted-by":"crossref","first-page":"e4660","DOI":"10.1371\/journal.pone.0004660","volume":"4","year":"2009","journal-title":"PLoS One"},{"key":"2026032120021050100_BIB56","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.jaci.2008.09.014","volume":"122","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"2026032120021050100_BIB57","first-page":"431","volume":"20","year":"2005","journal-title":"Environ Toxicol"},{"key":"2026032120021050100_BIB58","doi-asserted-by":"crossref","first-page":"L537","DOI":"10.1152\/ajplung.2001.280.3.L537","volume":"280","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026032120021050100_BIB59","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1165\/rcmb.2003-0373OC","volume":"30","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032120021050100_BIB60","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1084\/jem.20071507","volume":"205","year":"2008","journal-title":"J Exp Med"},{"key":"2026032120021050100_BIB61","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.taap.2003.09.025","volume":"194","year":"2004","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026032120021050100_BIB62","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.resp.2006.03.002","volume":"155","year":"2007","journal-title":"Respir Physiol Neurobiol"},{"key":"2026032120021050100_BIB63","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1152\/jappl.1984.57.4.1034","volume":"57","year":"1984","journal-title":"J Appl Physiol"},{"key":"2026032120021050100_BIB64","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1165\/rcmb.2008-0045OC","volume":"39","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032120021050100_BIB65","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.pharmthera.2009.02.007","volume":"122","year":"2009","journal-title":"Pharmacol Ther"}],"updated-by":[{"DOI":"10.1164\/rccm.1934retraction","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"record-id":"268"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/180\/12\/1218\/67442121\/ajrccm_180_12_1218.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/180\/12\/1218\/67442121\/ajrccm_180_12_1218.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:02:30Z","timestamp":1774137750000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/180\/12\/1218\/8525570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":65,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2009,12,15]]},"published-print":{"date-parts":[[2009,12,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.200901-0116oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2009,12]]},"published":{"date-parts":[[2009,12]]}}}