{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:13:31Z","timestamp":1791274411879,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Daycare exposes young children to more infections early in life and may thereby prevent the development of asthma and allergy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To prospectively study the effect of daycare on the development of asthma and allergic sensitization during the first 8 years of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the Prevention and Incidence of Asthma and Mite Allergy birth cohort 3,963 newborn children were followed prospectively for 8 years. Daycare use and respiratory health were assessed yearly by questionnaires. At 8 years, sensitization to airborne allergens and airway responsiveness were measured. Daycare was defined as early (aged 0\u20132 yr), late (aged 2\u20134 yr), or none (no daycare before age 4 yr). Associations of daycare and\/or older siblings with asthma symptoms (wheezing, shortness of breath, and inhaled steroids taken in the last year), airway responsiveness, and allergic sensitization were assessed in a longitudinal repeated-event analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Children with early daycare had more wheezing in the first years of life, but less wheezing and steroid use between 4 and 8 years of age. At the age of 8 years, early daycare was not protective for asthma symptoms (adjusted odds ratio [aOR], 0.99; 95% confidence interval [CI], 0.74\u20131.32), allergic sensitization (aOR 0.86; 95% CI, 0.63\u20131.18), or airway hyperresponsiveness (aOR, 0.80; 95% CI, 0.57\u20131.14). The transient reduction in airway symptoms between age 4 and 8 years was only observed in children without older siblings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early daycare is associated with an increase in airway symptoms until the age of 4 years, and fewer symptoms between the ages of 4 and 8 years. We found no protection against asthma symptoms, hyperresponsiveness, or allergic sensitization at the age of 8 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200903-0327oc","type":"journal-article","created":{"date-parts":[[2009,6,19]],"date-time":"2009-06-19T22:02:47Z","timestamp":1245448967000},"page":"491-498","source":"Crossref","is-referenced-by-count":71,"title":["Early Daycare Is Associated with an Increase in Airway Symptoms in Early Childhood but Is No Protection against Asthma or Atopy at 8 Years"],"prefix":"10.1093","volume":"180","author":[{"given":"Daan","family":"Caudri","sequence":"first","affiliation":[{"name":"Department of Pediatrics\/Respiratory Medicine, Erasmus University, Rotterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alet","family":"Wijga","sequence":"additional","affiliation":[{"name":"Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment (RIVM), 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