{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:56:42Z","timestamp":1791280602975,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0800196"],"award-info":[{"award-number":["G0800196"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0800195"],"award-info":[{"award-number":["G0800195"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Experimental Medicine Grant","award":["G0502019"],"award-info":[{"award-number":["G0502019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>A significant population of patients with severe asthma and chronic obstructive pulmonary disease is less responsive to \u03b22-adrenoceptor agonists and corticosteroids, and there are possible safety issues concerning long-term use of these drugs. Inhaled prostaglandin E2 (PGE2) is antiinflammatory and a bronchodilator in patients with asthma, but it also causes cough.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to identify the receptor involved in PGE2-induced sensory nerve activation and cough using a range of in vitro and in vivo techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Depolarization of vagal sensory nerves (human, mouse, and guinea pig) was assessed as an indicator of sensory nerve acitivity. Cough was measured in a conscious guinea pig model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Using an extensive range of pharmacological tools, we identified that the EP3 receptor mediates PGE2-induced depolarization of sensory nerves in human, mouse, and guinea pig. Further supporting evidence comes from data showing that responses to PGE2 are virtually abolished in isolated vagus nerves from EP3-deficient mice (Ptger3\u2212\/\u2212). Finally, we demonstrated the role of the EP3 receptor in vivo using a selective EP3 antagonist to attenuate PGE2-induced cough.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Identification of the receptor mediating PGE2-induced cough represents a key step in developing a drug that is antiinflammatory and a bronchodilator but without unwanted side effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200903-0388oc","type":"journal-article","created":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T22:21:14Z","timestamp":1252016474000},"page":"923-928","source":"Crossref","is-referenced-by-count":117,"title":["Prostaglandin E2 Mediates Cough via the EP3 Receptor: Implications for Future Disease Therapy"],"prefix":"10.1093","volume":"180","author":[{"given":"Sarah A.","family":"Maher","sequence":"first","affiliation":[{"name":"Respiratory Pharmacology, 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