{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:28:48Z","timestamp":1793082528966,"version":"4.5.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>There is limited knowledge about the relationship between respiratory symptoms and quantitative high-resolution computed tomography measures of emphysema and airway wall thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the ability of these measures of emphysema and airway wall thickness to predict respiratory symptoms in subjects with and without chronic obstructive pulmonary disease (COPD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 463 subjects with chronic obstructive pulmonary disease (COPD) (65% men) and 488 subjects without COPD (53% men). All subjects were current or ex-smokers older than 40 years. They underwent spirometry and high-resolution computed tomography examination, and completed an American Thoracic Society questionnaire on respiratory symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Median (25th percentile, 75th percentile) percent low-attenuation areas less than \u2212950 Hounsfield units (%LAA) was 7.0 (2.2, 17.8) in subjects with COPD and 0.5 (0.2, 1.3) in subjects without COPD. Mean (SD) standardized airway wall thickness (AWT) at an internal perimeter of 10 mm (AWT-Pi10) was 4.94 (0.33) mm in subjects with COPD and 4.77 (0.29) in subjects without COPD. Both %LAA and AWT-Pi10 were independently and significantly related to the level of dyspnea among subjects with COPD, even after adjustments for percent predicted FEV1. AWT-Pi10 was significantly related to cough and wheezing in subjects with COPD, and to wheezing in subjects without COPD. Odds ratios (95% confidence intervals) for increased dyspnea in subjects with COPD and in subjects without COPD were 1.9 (1.5\u20132.3) and 1.9 (0.6\u20136.6) per 10% increase in %LAA, and 1.07 (1.01\u20131.14) and 1.11 (0.99\u20131.24) per 0.1-mm increase in AWT-Pi10, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Quantitative computed tomography assessment of the lung parenchyma and airways may be used to explain the presence of respiratory symptoms beyond the information offered by spirometry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200907-1008oc","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T22:34:44Z","timestamp":1258670084000},"page":"353-359","source":"Crossref","is-referenced-by-count":188,"title":["Quantitative Computed Tomography Measures of Emphysema and Airway Wall Thickness Are Related to Respiratory Symptoms"],"prefix":"10.1093","volume":"181","author":[{"given":"Thomas B.","family":"Grydeland","sequence":"first","affiliation":[{"name":"Department of Thoracic Medicine, Haukeland University Hospital and"},{"name":"Institute of Medicine, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asger","family":"Dirksen","sequence":"additional","affiliation":[{"name":"Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey O.","family":"Coxson","sequence":"additional","affiliation":[{"name":"Department of Radiology and James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas M. L.","family":"Eagan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, Haukeland University Hospital and"},{"name":"Division of Physiology, Department of Medicine, University of California San Diego, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einar","family":"Thorsen","sequence":"additional","affiliation":[{"name":"Institute of Medicine, University of Bergen, Bergen, Norway"},{"name":"Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreekumar G.","family":"Pillai","sequence":"additional","affiliation":[{"name":"Pharmaceutical Exploratory Development, Hoffman-La Roche, Nutley, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Sharma","sequence":"additional","affiliation":[{"name":"Research and Development, GlaxoSmithKline, Research Triangle Park, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir Egil","family":"Eide","sequence":"additional","affiliation":[{"name":"Center for Clinical Research, Haukeland University Hospital and"},{"name":"Research Group on Lifestyle Epidemiology, Department of Public Health and Primary Care, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amund","family":"Gulsvik","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, Haukeland University Hospital and"},{"name":"Institute of Medicine, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per S.","family":"Bakke","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, Haukeland University Hospital and"},{"name":"Institute of Medicine, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,2,15]]},"reference":[{"key":"2026032504281962000_BIB1","first-page":"397","volume-title":"Eur Respir J","year":"2006"},{"key":"2026032504281962000_BIB2","first-page":"532","volume-title":"Am J Respir Crit Care Med","year":"2007"},{"key":"2026032504281962000_BIB3","first-page":"261","volume-title":"Eur Respir J","year":"2006"},{"key":"2026032504281962000_BIB4","first-page":"142","volume-title":"Am J Respir Crit Care Med","year":"2005"},{"key":"2026032504281962000_BIB5","first-page":"500","volume-title":"Am J Respir Crit Care Med","year":"2008"},{"key":"2026032504281962000_BIB6","first-page":"76","volume-title":"Clin Respir J","year":"2008"},{"key":"2026032504281962000_BIB7","first-page":"243","volume-title":"Am J Respir Crit Care Med","year":"2007"},{"key":"2026032504281962000_BIB8","first-page":"464","volume-title":"Chest","year":"2007"},{"key":"2026032504281962000_BIB9","first-page":"141","volume-title":"Eur Respir J","year":"1991"},{"key":"2026032504281962000_BIB10","first-page":"1102","volume-title":"Am J Respir Crit Care Med","year":"2000"},{"key":"2026032504281962000_BIB11","first-page":"177","volume-title":"COPD","year":"2008"},{"key":"2026032504281962000_BIB12","first-page":"558","volume-title":"Chest","year":"2006"},{"key":"2026032504281962000_BIB13","first-page":"1119","volume-title":"Thorax","year":"1999"},{"key":"2026032504281962000_BIB14"},{"key":"2026032504281962000_BIB15"},{"key":"2026032504281962000_BIB16","volume-title":"The Clinical Respiratory Journal","year":"2009"},{"key":"2026032504281962000_BIB17","first-page":"167","volume-title":"Am J Respir Crit Care Med","year":"2007"},{"key":"2026032504281962000_BIB18","first-page":"858","volume-title":"Eur Respir J","year":"2009"},{"key":"2026032504281962000_BIB19","first-page":"1","volume-title":"Am Rev Respir Dis","year":"1978"},{"key":"2026032504281962000_BIB20","first-page":"581","volume-title":"Thorax","year":"1999"},{"key":"2026032504281962000_BIB21","first-page":"648","volume-title":"Clin Physiol","year":"2001"},{"key":"2026032504281962000_BIB22","first-page":"153","volume-title":"Eur Respir J","year":"2005"},{"key":"2026032504281962000_BIB23","first-page":"653","volume-title":"Am J Respir Crit Care Med","year":"1995"},{"key":"2026032504281962000_BIB24","first-page":"1159","volume-title":"Stat Med","year":"2009"},{"key":"2026032504281962000_BIB25","first-page":"583","volume-title":"J Am Stat Assoc","year":"1952"},{"key":"2026032504281962000_BIB26","year":"2005"},{"key":"2026032504281962000_BIB27","first-page":"1017","volume-title":"AJR Am J Roentgenol","year":"1994"},{"key":"2026032504281962000_BIB28","first-page":"225","volume-title":"COPD","year":"2007"},{"key":"2026032504281962000_BIB29","first-page":"26","volume-title":"Proc Am Thorac Soc","year":"2005"},{"key":"2026032504281962000_BIB30","first-page":"35","volume-title":"Am J Respir Crit Care Med","year":"2009"},{"key":"2026032504281962000_BIB31","first-page":"275","volume-title":"Scand J Respir Dis","year":"1979"},{"key":"2026032504281962000_BIB32","first-page":"1320","volume-title":"Eur Respir J","year":"1999"},{"key":"2026032504281962000_BIB33","first-page":"286","volume-title":"Scand J Respir Dis","year":"1979"},{"key":"2026032504281962000_BIB34","first-page":"709","volume-title":"Lancet","year":"2004"},{"key":"2026032504281962000_BIB35","first-page":"134","volume-title":"Eur Respir J","year":"2007"},{"key":"2026032504281962000_BIB36","first-page":"426","volume-title":"J Appl Physiol","year":"2003"},{"key":"2026032504281962000_BIB37","first-page":"1016","volume-title":"Am J Respir Crit Care Med","year":"2000"},{"key":"2026032504281962000_BIB38","first-page":"599","volume-title":"Eur Respir J","year":"2002"},{"key":"2026032504281962000_BIB39","first-page":"775","volume-title":"J Clin Epidemiol","year":"2002"},{"key":"2026032504281962000_BIB40","first-page":"316","volume-title":"J Epidemiol Community Health","year":"1990"},{"key":"2026032504281962000_BIB41","first-page":"558","volume-title":"Am J Epidemiol","year":"2003"},{"key":"2026032504281962000_BIB42","first-page":"589","volume-title":"Eur Respir J","year":"2004"},{"key":"2026032504281962000_BIB43","first-page":"741","volume-title":"Lancet","year":"2007"},{"key":"2026032504281962000_BIB44","first-page":"448","volume-title":"Radiology","year":"2001"},{"key":"2026032504281962000_BIB45","first-page":"2645","volume-title":"N Engl J Med","year":"2004"},{"key":"2026032504281962000_BIB46","first-page":"874","volume-title":"Proc Am Thorac Soc","year":"2008"},{"key":"2026032504281962000_BIB47","first-page":"260","volume-title":"Am J Respir Crit Care Med","year":"1995"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/181\/4\/353\/67506575\/ajrccm_181_4_353.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/181\/4\/353\/67506575\/ajrccm_181_4_353.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:33:25Z","timestamp":1774427605000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/181\/4\/353\/8515433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":47,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,2,15]]},"published-print":{"date-parts":[[2010,2,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.200907-1008oc","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.2610958.2269056","asserted-by":"object"}]},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,2]]},"published":{"date-parts":[[2010,2]]}}}