{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:32:12Z","timestamp":1790872332297,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Little is known about the incidence of isoniazid-associated hepatitis in HIV-infected Africans who receive both isoniazid preventive therapy (IPT) and antiretroviral therapy (ART).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the rate of and risk factors for isoniazid (INH)-associated hepatitis in persons living with HIV (PLWH) during IPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PLWH recruited for a clinical trial received 6 months of open-label, daily, self-administered INH at public health clinics. At screening PLWH were excluded if they had any cough, weight loss, night sweats, or other illness. Alcohol abuse was defined as meeting any CAGE criterion. INH-associated hepatitis (INH-hepatitis) was defined as having either alanine or aspartate aminotransferase greater than 5.0 times the upper limit of normal regardless of symptoms when INH was not excluded as the cause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Of 1,995 PLWH enrolled between 2004 and 2006, 1,762 adhered to at least 4 months of IPT and were analyzed. Nineteen (1.1%) developed hepatitis probably or possibly associated with INH including one death at month 6; 14 of 19 (74%) occurred in months 1\u20133. Antiretroviral therapy (ART) was received by 480 participants but was not statistically associated with INH-hepatitis (relative risk [RR], 1.56; 95% confidence intervals [CI], 0.62\u20133.9); those receiving nevirapine had a higher rate (2.0%) than those receiving efavirenz (0.9%; P = 0.34). Although alcohol use did not reach significance (RR, 1.42; 95% CI, 0.57\u20133.51), meeting at least one CAGE criterion approached statistical significance (RR, 2.37; 95% CI, 0.96\u20135.84). Neither age greater than 35 years nor the presence of hepatitis B virus core antibody was associated with INH-hepatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The observed rates of INH-hepatitis were similar to published data. Six months of IPT, which is recommended by the World Health Organization, was relatively safe in this, the largest cohort of African PLWH.<\/jats:p>\n                    <jats:p>Clinical trial registered with www.clinicaltrials.gov (NCT00164281).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200911-1783oc","type":"journal-article","created":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T22:20:27Z","timestamp":1270765227000},"page":"278-285","source":"Crossref","is-referenced-by-count":27,"title":["Isoniazid-associated Hepatitis and Antiretroviral Drugs during Tuberculosis Prophylaxis in HIV-infected Adults in Botswana"],"prefix":"10.1093","volume":"182","author":[{"given":"Zegabriel","family":"Tedla","sequence":"first","affiliation":[{"name":"BOTUSA, Gaborone and Francistown, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samba","family":"Nyirenda","sequence":"additional","affiliation":[{"name":"BOTUSA, Gaborone and Francistown, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crandall","family":"Peeler","sequence":"additional","affiliation":[{"name":"BOTUSA, Gaborone and Francistown, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tefera","family":"Agizew","sequence":"additional","affiliation":[{"name":"BOTUSA, Gaborone and Francistown, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thabisa","family":"Sibanda","sequence":"additional","affiliation":[{"name":"BOTUSA, Gaborone and Francistown, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oaitse","family":"Motsamai","sequence":"additional","affiliation":[{"name":"National Tuberculosis Program, Ministry of Health, Gaborone, Botswana; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Vernon","sequence":"additional","affiliation":[{"name":"Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Wells","sequence":"additional","affiliation":[{"name":"Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taraz","family":"Samandari","sequence":"additional","affiliation":[{"name":"BOTUSA, Gaborone and Francistown, and"},{"name":"Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,7,15]]},"reference":[{"key":"2026032101482520300_BIB1","first-page":"1009","volume-title":"Arch Intern Med","year":"2003"},{"key":"2026032101482520300_BIB2","year":"2005"},{"key":"2026032101482520300_BIB3","first-page":"55","volume-title":"Int J Tuberc Lung Dis","year":"2002"},{"key":"2026032101482520300_BIB4","first-page":"CD000171","volume-title":"Cochrane Database Syst Rev","year":"2004"},{"key":"2026032101482520300_BIB5","first-page":"S28","volume-title":"Int J Tuberc Lung Dis","year":"2005"},{"key":"2026032101482520300_BIB6","first-page":"96","volume-title":"Tuber Lung Dis","year":"1994"},{"key":"2026032101482520300_BIB7","year":"2008"},{"key":"2026032101482520300_BIB8","first-page":"991","volume-title":"Am Rev Respir Dis","year":"1978"},{"key":"2026032101482520300_BIB9","year":"2008"},{"key":"2026032101482520300_BIB10","first-page":"69","volume-title":"Curr Infect Dis Rep","year":"2008"},{"key":"2026032101482520300_BIB11","first-page":"S449","volume-title":"J Infect Dis","year":"2007"},{"key":"2026032101482520300_BIB12","first-page":"13","volume-title":"Mem Inst Oswaldo Cruz","year":"2005"},{"key":"2026032101482520300_BIB13","first-page":"856","volume-title":"Sex Transm Dis","year":"2007"},{"key":"2026032101482520300_BIB14","first-page":"311","volume-title":"Int J STD AIDS","year":"2002"},{"key":"2026032101482520300_BIB15","year":"2003"},{"key":"2026032101482520300_BIB16","first-page":"33","volume-title":"Clin Invest Med","year":"2007"},{"key":"2026032101482520300_BIB17","first-page":"1239","volume-title":"JAMA","year":"1979"},{"key":"2026032101482520300_BIB18","first-page":"1014","volume-title":"JAMA","year":"1999"},{"key":"2026032101482520300_BIB19","first-page":"799","volume-title":"Ann Intern Med","year":"1990"},{"key":"2026032101482520300_BIB20","first-page":"494","volume-title":"Am Rev Respir Dis","year":"1992"},{"key":"2026032101482520300_BIB21","first-page":"71","volume-title":"J Acquir Immune Defic Syndr","year":"2010"},{"key":"2026032101482520300_BIB22","first-page":"895","volume-title":"Clin Infect Dis","year":"1999"},{"key":"2026032101482520300_BIB23","first-page":"1","volume-title":"MMWR Recomm Rep","year":"2000"},{"key":"2026032101482520300_BIB24","first-page":"700","volume-title":"Am Rev Respir Dis","year":"1989"},{"key":"2026032101482520300_BIB25","first-page":"1301","volume-title":"AIDS","year":"2007"},{"key":"2026032101482520300_BIB26","first-page":"935","volume-title":"Am J Respir Crit Care Med","year":"2006"},{"key":"2026032101482520300_BIB27","year":"2008"},{"key":"2026032101482520300_BIB28","first-page":"1133","volume-title":"J Infect Dis","year":"2008"},{"key":"2026032101482520300_BIB29","first-page":"379","volume-title":"J Gen Intern Med","year":"1998"},{"key":"2026032101482520300_BIB30","first-page":"e392","volume-title":"PLoS Med","year":"2006"},{"key":"2026032101482520300_BIB31","first-page":"7","volume-title":"Subst Abus","year":"2007"},{"key":"2026032101482520300_BIB32","first-page":"541","volume-title":"S Afr Med J","year":"2008"},{"key":"2026032101482520300_BIB33","first-page":"1612","volume-title":"Clin Infect Dis","year":"2006"},{"key":"2026032101482520300_BIB34","first-page":"S107","volume-title":"Vaccine","year":"1990"},{"key":"2026032101482520300_BIB35","first-page":"1221","volume-title":"AIDS","year":"2008"},{"key":"2026032101482520300_BIB36","first-page":"1198","volume-title":"Am J Gastroenterol","year":"2002"},{"key":"2026032101482520300_BIB37","first-page":"1304","volume-title":"Chest","year":"2005"},{"key":"2026032101482520300_BIB38","first-page":"S65","volume-title":"Clin Infect Dis","year":"2004"},{"key":"2026032101482520300_BIB39","first-page":"314","volume-title":"Psychol Health Med","year":"2007"},{"key":"2026032101482520300_BIB40","first-page":"229","volume-title":"Clin Biochem","year":"2001"},{"key":"2026032101482520300_BIB41","first-page":"731","volume-title":"N Engl J Med","year":"2006"},{"key":"2026032101482520300_BIB42","first-page":"1441","volume-title":"AIDS","year":"2007"},{"key":"2026032101482520300_BIB43","first-page":"631","volume-title":"AIDS","year":"2009"},{"key":"2026032101482520300_BIB44","first-page":"1445","volume-title":"N Engl J Med","year":"2007"},{"key":"2026032101482520300_BIB45","first-page":"801","volume-title":"N Engl J Med","year":"1997"},{"key":"2026032101482520300_BIB46","first-page":"875","volume-title":"AIDS","year":"1997"},{"key":"2026032101482520300_BIB47","first-page":"443","volume-title":"Am J Respir Crit Care Med","year":"2003"},{"key":"2026032101482520300_BIB48","first-page":"315","volume-title":"N Engl J Med","year":"1997"},{"key":"2026032101482520300_BIB49","first-page":"1445","volume-title":"JAMA","year":"2000"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/182\/2\/278\/67306018\/ajrccm_182_2_278.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/182\/2\/278\/67306018\/ajrccm_182_2_278.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T05:48:32Z","timestamp":1774072112000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/182\/2\/278\/8514997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,7,15]]},"published-print":{"date-parts":[[2010,7,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.200911-1783oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,7]]},"published":{"date-parts":[[2010,7]]}}}