{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:12:51Z","timestamp":1781788371823,"version":"3.54.5"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Chronic lung disease characterized by loss of lung tissue, inflammation, and fibrosis represents a major global health burden. Cellular therapies that could restore pneumocytes and reduce inflammation and fibrosis would be a major advance in management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether human amnion epithelial cells (hAECs), isolated from term placenta and having stem cell\u2013like and antiinflammatory properties, could adopt an alveolar epithelial phenotype and repair a murine model of bleomycin-induced lung injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Primary hAECs were cultured in small airway growth medium to determine whether the cells could adopt an alveolar epithelial phenotype. Undifferentiated primary hAECs were also injected parenterally into SCID mice after bleomycin-induced lung injury and analyzed for production of surfactant protein (SP)-A, SP-B, SP-C, and SP-D. Mouse lungs were also analyzed for inflammation and collagen deposition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>hAECs grown in small airway growth medium developed an alveolar epithelial phenotype with lamellar body formation, production of SPs A\u2013D, and SP-D secretion. Although hAECs injected into mice lacked SPs, hAECs recovered from mouse lungs 2 weeks post-transplantation produced SPs. hAECs remained engrafted over the 4-week test period. hAEC administration reduced inflammation in association with decreased monocyte chemoattractant protein-1, tumor necrosis factor-\u03b1, IL-1 and -6, and profibrotic transforming growth factor-\u03b2 in mouse lungs. In addition, lung collagen content was significantly reduced by hAEC treatment as a possible consequence of increased degradation by matrix metalloproteinase-2 and down-regulation of the tissue inhibitors of matrix metalloproteinase-1 and 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>hAECs offer promise as a cellular therapy for alveolar restitution and to reduce lung inflammation and fibrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201001-0014oc","type":"journal-article","created":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T23:01:26Z","timestamp":1275606086000},"page":"643-651","source":"Crossref","is-referenced-by-count":180,"title":["Human Amnion Epithelial Cell Transplantation Abrogates Lung Fibrosis and Augments Repair"],"prefix":"10.1093","volume":"182","author":[{"given":"Yuben","family":"Moodley","sequence":"first","affiliation":[{"name":"Monash Immunology and Stem Cell Laboratories, School of Biomedical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivagami","family":"Ilancheran","sequence":"additional","affiliation":[{"name":"Centre for Women's Health Research, Monash Institute of Medical Research (MIMR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrishan","family":"Samuel","sequence":"additional","affiliation":[{"name":"Howard Florey Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijesh","family":"Vaghjiani","sequence":"additional","affiliation":[{"name":"Centre for Reproduction and Development, MIMR, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Atienza","sequence":"additional","affiliation":[{"name":"Monash Immunology and Stem Cell Laboratories, School of 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