{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:22:52Z","timestamp":1791508972800,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Respiratory specimens with nontuberculous mycobacteria (NTM) are increasingly common; however, pulmonary disease prevalence is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the disease prevalence, clinical features, and risk factors for NTM disease, and to examine the predictive value of the microbiologic criteria of the American Thoracic Society (ATS)\/Infectious Diseases Society of America (IDSA) pulmonary NTM case definition for true NTM disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified all Oregon residents during 2005\u20132006 with at least one respiratory mycobacterial isolate. From a population-based subset of these patients, we collected clinical and radiologic information and used the ATS\/IDSA pulmonary NTM disease criteria to define disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>In the 2-year time period, 807 Oregonians had one or more respiratory NTM isolates. Four hundred and seven (50%) resided within the Portland metropolitan region, among which 283 (70%) had evaluable clinical records. For those with records, 134 (47%) met ATS\/IDSA pulmonary NTM disease criteria for a minimum overall 2-year period prevalence of 8.6\/100,000 persons, and 20.4\/100,000 in those at least 50 years of age within the Portland region. Case subjects were 66 years of age (median; range, 12\u201392 yr), frequently female (59%), and most with disease caused by Mycobacterium avium complex (88%). Cavitation (24.5%), bronchiectasis (16%), chronic obstructive pulmonary disease (28%), and immunosuppressive therapy (25.5%) were common. Eighty-six percent of patients meeting the ATS\/IDSA microbiologic criteria for disease also met the full ATS\/IDSA disease criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Respiratory NTM isolates frequently represent disease. Pulmonary NTM disease is not uncommon, particularly among elderly females. The ATS\/IDSA microbiologic criteria are highly predictive of disease and could be useful for laboratory-based NTM disease surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201003-0503oc","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T22:41:09Z","timestamp":1275000069000},"page":"977-982","source":"Crossref","is-referenced-by-count":369,"title":["Pulmonary Nontuberculous Mycobacterial Disease Prevalence and Clinical Features: An Emerging Public Health Disease"],"prefix":"10.1093","volume":"182","author":[{"given":"Kevin L.","family":"Winthrop","sequence":"first","affiliation":[{"name":"Oregon Health & Science University and"},{"name":"Oregon Public Health Division, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"McNelley","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University and"},{"name":"Oregon Public Health Division, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kendall","sequence":"additional","affiliation":[{"name":"Oregon Public Health Division, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Marshall-Olson","sequence":"additional","affiliation":[{"name":"Oregon Public Health Division, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy","family":"Morris","sequence":"additional","affiliation":[{"name":"Oregon Public Health Division, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Cassidy","sequence":"additional","affiliation":[{"name":"Oregon Public Health Division, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlen","family":"Saulson","sequence":"additional","affiliation":[{"name":"Oregon Public Health Division, Portland, 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