{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:35:18Z","timestamp":1789209318110,"version":"build-2803163510"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Bronchiectasis is a chronic debilitating disease with few evidence-based long-term treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>A randomized controlled trial assessing the efficacy of nebulized gentamicin therapy over 1 year in patients with non\u2013cystic fibrosis bronchiectasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty-five patients were randomized to either twice-daily nebulized gentamicin, 80 mg, or nebulized 0.9% saline, for 12 months. All were reviewed at three-monthly intervals during treatment and at 3 months' follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>At each review the following were assessed: quantitative and qualitative sputum bacteriology; sputum purulence and 24-hour volume; FEV1, FVC, and forced expiratory flow, midexpiratory phase; exercise capacity; Leicester Cough Questionnaire and St. George's Respiratory Questionnaire; and exacerbation frequency. Fifty-seven patients completed the study. At the end of 12 months' treatment, compared with the saline group, in the gentamicin group there was reduced sputum bacterial density with 30.8% eradication in those infected with Pseudomonas aeruginosa and 92.8% eradication in those infected with other pathogens; less sputum purulence (8.7% vs. 38.5%; P &amp;lt; 0.0001); greater exercise capacity (510 [350\u2013690] m vs. 415 [267.5\u2013530] m; P = 0.03); and fewer exacerbations (0 [0\u20131] vs. 1.5 [1\u20132]; P &amp;lt; 0.0001) with increased time to first exacerbation (120 [87\u2013161.5] d vs. 61.5 [20.7\u2013122.7] d; P = 0.02). The gentamicin group had greater improvements in Leicester Cough Questionnaire (81.4% vs. 20%; P &amp;lt; 0.01) and St. George's Respiratory Questionnaire (87.5% vs. 19.2%; P &amp;lt; 0.004) score. No differences were seen in 24-hour sputum volume, FEV1, FVC, or forced expiratory flow, midexpiratory phase. No P. aeruginosa isolates developed resistance to gentamicin. At follow-up, all outcome measures were similar to baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Regular, long-term nebulized gentamicin is of significant benefit in non\u2013cystic fibrosis bronchiectasis but treatment needs to be continuous for its ongoing efficacy.<\/jats:p>\n                    <jats:p>Clinical trial registered with www.clinicaltrials.gov (NCT00749866).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201005-0756oc","type":"journal-article","created":{"date-parts":[[2010,9,24]],"date-time":"2010-09-24T22:50:44Z","timestamp":1285368644000},"page":"491-499","source":"Crossref","is-referenced-by-count":253,"title":["A Randomized Controlled Trial of Nebulized Gentamicin in Non\u2013Cystic Fibrosis Bronchiectasis"],"prefix":"10.1093","volume":"183","author":[{"given":"Maeve P.","family":"Murray","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom"},{"name":"School of Medicine and Veterinary Medicine, Cystic Fibrosis Group, Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom"},{"name":"The University of Edinburgh\/MRC Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R. W.","family":"Govan","sequence":"additional","affiliation":[{"name":"School of Medicine and Veterinary Medicine, Cystic Fibrosis Group, Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine J.","family":"Doherty","sequence":"additional","affiliation":[{"name":"School of Medicine and Veterinary Medicine, Cystic Fibrosis Group, Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. John","family":"Simpson","sequence":"additional","affiliation":[{"name":"The University of Edinburgh\/MRC Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"The University of Edinburgh\/MRC Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Chalmers","sequence":"additional","affiliation":[{"name":"The University of Edinburgh\/MRC Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Greening","sequence":"additional","affiliation":[{"name":"The University of Edinburgh\/MRC Centre for Inflammation Research, The Queen's 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