{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:39:40Z","timestamp":1774078780307,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>The function of the P2X7 nucleotide receptor protects against exacerbation in people with mild-intermittent asthma during viral illnesses, but the impact of disease severity and maintenance therapy has not been studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the association between P2X7, asthma exacerbations, and incomplete symptom control in a more diverse population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A matched P2RX7 genetic case-control was performed with samples from Asthma Clinical Research Network trial participants enrolled before July 2006, and P2X7 pore activity was determined in whole blood samples as an ancillary study to two trials completed subsequently.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>A total of 187 exacerbations were studied in 742 subjects, and the change in asthma symptom burden was studied in an additional 110 subjects during a trial of inhaled corticosteroids (ICS) dose optimization. African American carriers of the minor G allele of the rs2230911 loss-of-function single nucleotide polymorphism were more likely to have a history of prednisone use in the previous 12 months, with adjustment for ICS and long-acting \u03b22-agonists use (odds ratio, 2.7; 95% confidence interval, 1.2\u20136.2; P = 0.018). Despite medium-dose ICS, attenuated pore function predicted earlier exacerbations in incompletely controlled patients with moderate asthma (hazard ratio, 3.2; confidence interval, 1.1\u20139.3; P = 0.033). After establishing control with low-dose ICS in patients with mild asthma, those with attenuated pore function had more asthma symptoms, rescue albuterol use, and FEV1 reversal (P &amp;lt; 0.001, 0.03, and 0.03, respectively) during the ICS adjustment phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>P2X7 pore function protects against exacerbations of asthma and loss of control, independent of baseline severity and the maintenance therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201204-0750oc","type":"journal-article","created":{"date-parts":[[2012,11,10]],"date-time":"2012-11-10T21:04:55Z","timestamp":1352581495000},"page":"28-33","source":"Crossref","is-referenced-by-count":17,"title":["P2X7-Regulated Protection from Exacerbations and Loss of Control Is Independent of Asthma Maintenance Therapy"],"prefix":"10.1093","volume":"187","author":[{"given":"Loren C.","family":"Denlinger","sequence":"first","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Manthei","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max A.","family":"Seibold","sequence":"additional","affiliation":[{"name":"National Jewish Health, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwangmi","family":"Ahn","sequence":"additional","affiliation":[{"name":"Pennsylvania State University, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Bleecker","sequence":"additional","affiliation":[{"name":"Wake Forest University Health Sciences, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homer A.","family":"Boushey","sequence":"additional","affiliation":[{"name":"University of California, San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Calhoun","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch at Galveston, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Castro","sequence":"additional","affiliation":[{"name":"Washington University, St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vernon M.","family":"Chinchili","sequence":"additional","affiliation":[{"name":"Pennsylvania State University, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John V.","family":"Fahy","sequence":"additional","affiliation":[{"name":"University of California, San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg A.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Wake Forest University Health Sciences, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolina","family":"Icitovic","sequence":"additional","affiliation":[{"name":"Pennsylvania State University, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot","family":"Israel","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizar N.","family":"Jarjour","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonya","family":"King","sequence":"additional","affiliation":[{"name":"Pennsylvania State University, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Kraft","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Lazarus","sequence":"additional","affiliation":[{"name":"University of California, San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Lehman","sequence":"additional","affiliation":[{"name":"Pennsylvania State University, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Martin","sequence":"additional","affiliation":[{"name":"National Jewish Health, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah A.","family":"Meyers","sequence":"additional","affiliation":[{"name":"Wake Forest University Health Sciences, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen P.","family":"Peters","sequence":"additional","affiliation":[{"name":"Wake Forest University Health Sciences, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagna","family":"Sheerar","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Rand","family":"Sutherland","sequence":"additional","affiliation":[{"name":"National Jewish Health, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley J.","family":"Szefler","sequence":"additional","affiliation":[{"name":"National Jewish Health, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Wechsler","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A.","family":"Sorkness","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Robert F.","family":"Lemanske","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"2026032100502226400_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2222.2008.03118.x","article-title":"The danger within: endogenous danger signals, atopy and asthma","volume":"39","author":"Willart","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"2026032100502226400_bib2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nm1617","article-title":"Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells","volume":"13","author":"Idzko","year":"2007","journal-title":"Nat Med"},{"key":"2026032100502226400_bib3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1183\/09031936.02.00226302","article-title":"Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma","volume":"19","author":"Wark","year":"2002","journal-title":"Eur Respir J"},{"key":"2026032100502226400_bib4","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1183\/09031936.00089807","article-title":"Extracellular purines are biomarkers of neutrophilic airway inflammation","volume":"31","author":"Esther","year":"2008","journal-title":"Eur Respir J"},{"key":"2026032100502226400_bib5","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.272.5262.735","article-title":"The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)","volume":"272","author":"Surprenant","year":"1996","journal-title":"Science"},{"key":"2026032100502226400_bib6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.tips.2007.07.002","article-title":"Liaisons dangereuses: P2X(7) and the inflammasome","volume":"28","author":"Di Virgilio","year":"2007","journal-title":"Trends Pharmacol Sci"},{"key":"2026032100502226400_bib7","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1165\/rcmb.2010-0129OC","article-title":"A potential role for P2X7R in allergic airway inflammation in mice and humans","volume":"44","author":"M\u00fcller","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032100502226400_bib8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1164\/rccm.200802-293OC","article-title":"Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control","volume":"179","author":"Denlinger","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100502226400_bib9","first-page":"347","article-title":"Gene structure and chromosomal localization of the human P2X7 receptor","volume":"5","author":"Buell","year":"1998","journal-title":"Receptors Channels"},{"key":"2026032100502226400_bib10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/geno.1996.0518","article-title":"Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: evidence from Afro-Caribbean and caucasian populations","volume":"37","author":"Barnes","year":"1996","journal-title":"Genomics"},{"key":"2026032100502226400_bib11","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1164\/ajrccm.162.5.2002113","article-title":"Genome screen for asthma and related phenotypes in the French EGEA study","volume":"162","author":"Dizier","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100502226400_bib12","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1086\/321190","article-title":"Major genes regulating total serum immunoglobulin E levels in families with asthma","volume":"67","author":"Xu","year":"2000","journal-title":"Am J Hum Genet"},{"key":"2026032100502226400_bib13","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1093\/hmg\/ddg208","article-title":"Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes","volume":"12","author":"Raby","year":"2003","journal-title":"Hum Mol Genet"},{"key":"2026032100502226400_bib14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10038-003-0118-z","article-title":"Linkage and association of childhood asthma with the chromosome 12 genes","volume":"49","author":"Shao","year":"2004","journal-title":"J Hum Genet"},{"key":"2026032100502226400_bib15","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/thx.2005.055475","article-title":"Significant linkage to chromosome 12q24.32-q24.33 and identification of sfrs8 as a possible asthma susceptibility gene","volume":"61","author":"Brasch-Andersen","year":"2006","journal-title":"Thorax"},{"key":"2026032100502226400_bib16","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00439-006-0255-5","article-title":"Significant linkage to airway responsiveness on chromosome 12q24 in families of children with asthma in Costa Rica","volume":"120","author":"Celedon","year":"2007","journal-title":"Hum Genet"},{"key":"2026032100502226400_bib17","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11302-009-9136-4","article-title":"Genetics of the P2X7 receptor and human disease","volume":"5","author":"Fuller","year":"2009","journal-title":"Purinergic Signal"},{"key":"2026032100502226400_bib18","doi-asserted-by":"crossref","first-page":"11135","DOI":"10.1074\/jbc.M010353200","article-title":"A glu-496 to ALA polymorphism leads to loss of function of the human P2X7 receptor","volume":"276","author":"Gu","year":"2001","journal-title":"J Biol Chem"},{"key":"2026032100502226400_bib19","doi-asserted-by":"crossref","first-page":"17108","DOI":"10.1074\/jbc.M212759200","article-title":"An ile-568 to as polymorphism prevents normal trafficking and function of the human P2X7 receptor","volume":"278","author":"Wiley","year":"2003","journal-title":"J Biol Chem"},{"key":"2026032100502226400_bib20","doi-asserted-by":"crossref","first-page":"31287","DOI":"10.1074\/jbc.M313902200","article-title":"An arg307 to glen polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor","volume":"279","author":"Gu","year":"2004","journal-title":"J Biol Chem"},{"key":"2026032100502226400_bib21","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1074\/jbc.M507816200","article-title":"A thr357 to ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages","volume":"281","author":"Shemon","year":"2006","journal-title":"J Biol Chem"},{"key":"2026032100502226400_bib22","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jpsychires.2009.10.005","article-title":"Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions","volume":"44","author":"Roger","year":"2010","journal-title":"J Psychiatr Res"},{"key":"2026032100502226400_bib23","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1373\/clinchem.2005.065425","article-title":"Human P2X7 pore function predicts allele linkage disequilibrium","volume":"52","author":"Denlinger","year":"2006","journal-title":"Clin Chem"},{"key":"2026032100502226400_bib24","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1096\/fj.09-150862","article-title":"Two haplotypes of the P2X(7) receptor containing the ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretion","volume":"24","author":"Stokes","year":"2010","journal-title":"FASEB J"},{"key":"2026032100502226400_bib25","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.4049\/jimmunol.174.7.4424","article-title":"Detection of human P2X7 nucleotide receptor polymorphisms by a novel monocyte pore assay predictive of alterations in lipopolysaccharide-induced cytokine production","volume":"174","author":"Denlinger","year":"2005","journal-title":"J Immunol"},{"key":"2026032100502226400_bib26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/cyto.b.20421","article-title":"Standardized method to minimize variability in a functional P2X(7) flow cytometric assay for a multi-center clinical trial","volume":"74","author":"Korpi-Steiner","year":"2008","journal-title":"Cytometry B Clin Cytom"},{"key":"2026032100502226400_bib27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1165\/rcmb.2011-0267OC","article-title":"Rhinovirus-induced IL-1beta release from bronchial epithelial cells is independent of functional P2X7","volume":"47","author":"Shi","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032100502226400_bib28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2006.10.015","article-title":"Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research and Education Network","volume":"119","author":"Denlinger","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"2026032100502226400_bib29","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jaci.2010.07.024","article-title":"A trial of clarithromycin for the treatment of suboptimally controlled asthma","volume":"126","author":"Sutherland","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"2026032100502226400_bib30","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1001\/2012.jama.10893","article-title":"Comparison of inhaled corticosteroid adjustment strategies for long term asthma management: the ACRN BASALT trial","volume":"308","author":"Calhoun","year":"2012","journal-title":"JAMA"},{"key":"2026032100502226400_bib31","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jaci.2012.05.040","article-title":"Protection from asthma in a high-risk birth cohort by attenuated P2X7 function","volume":"130","author":"Manthei","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"2026032100502226400_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/sj.bjp.0707196","article-title":"Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding","volume":"151","author":"Michel","year":"2007","journal-title":"Br J Pharmacol"},{"key":"2026032100502226400_bib33","doi-asserted-by":"crossref","first-page":"14213","DOI":"10.1523\/JNEUROSCI.2390-10.2010","article-title":"Experimental characterization and mathematical modeling of P2X7 receptor channel gating","volume":"30","author":"Yan","year":"2010","journal-title":"J Neurosci"},{"key":"2026032100502226400_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000291927","article-title":"Approaches for evaluating rare polymorphisms in genetic association studies","volume":"69","author":"Li","year":"2010","journal-title":"Hum Hered"},{"key":"2026032100502226400_bib35","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.4049\/jimmunol.160.5.2469","article-title":"Post-translational processing of murine IL-1: evidence that ATP-induced release of IL-1 alpha and IL-1 beta occurs via a similar mechanism","volume":"160","author":"Perregaux","year":"1998","journal-title":"J Immunol"},{"key":"2026032100502226400_bib36","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1126\/science.1195491","article-title":"Intravascular danger signals guide neutrophils to sites of sterile inflammation","volume":"330","author":"McDonald","year":"2010","journal-title":"Science"},{"key":"2026032100502226400_bib37","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.bbamem.2009.03.006","article-title":"Expression of purinergic receptors and modulation of P2X7 function by the inflammatory cytokine IFNgamma in human epithelial cells","volume":"1788","author":"Welter-Stahl","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"2026032100502226400_bib38","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1517\/14728220903277249","article-title":"P2X7-mediated chemoprevention of epithelial cancers","volume":"13","author":"Gorodeski","year":"2009","journal-title":"Expert Opin Ther Targets"},{"key":"2026032100502226400_bib39","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1182\/blood-2009-11-251744","article-title":"The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP","volume":"115","author":"Gu","year":"2010","journal-title":"Blood"},{"key":"2026032100502226400_bib40","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1084\/jem.20041901","article-title":"Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus","volume":"201","author":"Wark","year":"2005","journal-title":"J Exp Med"},{"key":"2026032100502226400_bib41","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1165\/rcmb.2006-0014OC","article-title":"Roles of apoptosis in airway epithelia","volume":"34","author":"Tesfaigzi","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032100502226400_bib42","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1164\/rccm.200501-035OC","article-title":"Defective apoptotic cell phagocytosis attenuates prostaglandin E2 and 15-hydroxyeicosatetraenoic acid in severe asthma alveolar macrophages","volume":"172","author":"Huynh","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100502226400_bib43","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.jaci.2008.03.008","article-title":"Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma","volume":"121","author":"Fitzpatrick","year":"2008","journal-title":"J Allergy Clin Immunol"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/187\/1\/28\/67265845\/ajrccm_187_1_28.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/187\/1\/28\/67265845\/ajrccm_187_1_28.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:52:26Z","timestamp":1774068746000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/187\/1\/28\/8509925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,1]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,1]]},"published-print":{"date-parts":[[2013,1,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201204-0750oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,1]]},"published":{"date-parts":[[2013,1,1]]}}}