{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:23:27Z","timestamp":1791509007300,"version":"4.3.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>The prevalence of bronchiectasis is high in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) and it has been associated with exacerbations and bacterial colonization. These have demonstrated some degree of prognostic value in patients with COPD but no information about the relationship between bronchiectasis and mortality in patients with COPD is currently available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the prognostic value of bronchiectasis in patients with moderate-to-severe COPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicenter prospective observational study in consecutive patients with moderate-to-severe COPD. Bronchiectasis was diagnosed by high-resolution computed tomography scan. A complete standardized protocol was used in all patients covering general, anthrophometric, functional, clinical, and microbiologic data. After follow-up, the vital status was recorded in all patients. Multivariate Cox analysis was used to determine the independent adjusted prognostic value of bronchiectasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Ninety-nine patients in Global Initiative for Chronic Obstructive Lung Disease (GOLD) II, 85 in GOLD III, and 17 in GOLD IV stages were included. Bronchiectasis was present in 115 (57.2%) patients. During the follow-up (median, 48 mo [interquartile range, 35\u201353]) there were 51 deaths (43 deaths in the bronchiectasic group). Bronchiectasis was associated with an increased risk of fully adjusted mortality (hazard ratio, 2.54; 95% confidence interval, 1.16\u20135.56; P = 0.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bronchiectasis was associated with an independent increased risk of all-cause mortality in patients with moderate-to-severe COPD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201208-1518oc","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T03:10:28Z","timestamp":1360293028000},"page":"823-831","source":"Crossref","is-referenced-by-count":247,"title":["Prognostic Value of Bronchiectasis in Patients with Moderate-to-Severe Chronic Obstructive Pulmonary Disease"],"prefix":"10.1093","volume":"187","author":[{"given":"Miguel-Angel","family":"Mart\u00ednez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Pneumology Service, Polytechnic and University La Fe Hospital, Valencia, Spain"},{"name":"CIBERes, CIBER de Enfermedades Respiratorias, Bunyola, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"de la Rosa Carrillo","sequence":"additional","affiliation":[{"name":"Pneumology Unit, Plat\u00f3n Hospital, Barcelona, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Jose","family":"Soler-Catalu\u00f1a","sequence":"additional","affiliation":[{"name":"Internal Medicine Service"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Donat-Sanz","sequence":"additional","affiliation":[{"name":"Internal Medicine Service"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Catal\u00e1n","family":"Serra","sequence":"additional","affiliation":[{"name":"Internal Medicine Service"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Agramunt","family":"Lerma","sequence":"additional","affiliation":[{"name":"Radiology Service, Hospital General de Requena, Valencia, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ballest\u00edn","sequence":"additional","affiliation":[{"name":"Radiology Service, Hospital General de Requena, Valencia, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Valero","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Pneumology Service, Polytechnic and University La Fe Hospital, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jose","family":"Selma Ferrer","sequence":"additional","affiliation":[{"name":"Pneumology Service, Polytechnic and University La Fe Hospital, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Roma","family":"Dalfo","sequence":"additional","affiliation":[{"name":"Radiology Department, Plat\u00f3n Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat Bertomeu","family":"Valdecillos","sequence":"additional","affiliation":[{"name":"Radiology Department, Plat\u00f3n Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"2026032100565946900_bib1","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0140-6736(96)07493-4","article-title":"Mortality by cause for eight regions of the world global burden of disease study","volume":"349","author":"Murria","year":"1997","journal-title":"Lancet"},{"key":"2026032100565946900_bib2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1164\/arrd.1986.133.1.14","article-title":"Prognosis in chronic obstructive pulmonary disease","volume":"133","author":"Anthonisen","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"2026032100565946900_bib3","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa021322","article-title":"The body mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease","volume":"350","author":"Celli","year":"2004","journal-title":"N Engl J Med"},{"key":"2026032100565946900_bib4","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1164\/rccm.200206-583OC","article-title":"Analysis of the factors related to mortality in chronic obstructive pulmonary disease. Role of exercise capacity and health status","volume":"167","author":"Oga","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100565946900_bib5","first-page":"79","article-title":"Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample. Findings from the Copenhagen City Heart Study","volume":"73","author":"Vestbo","year":"2006","journal-title":"Am Respir J Crit Care Med"},{"key":"2026032100565946900_bib6","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1164\/rccm.2112043","article-title":"Health-related quality of life and mortality in male patients with chronic obstructive pulmonary disease","volume":"166","author":"Domingo-Salvany","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100565946900_bib7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1513\/pats.200709-148ET","article-title":"Comorbidities in chronic obstructive pulmonary disease","volume":"5","author":"Chatila","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"2026032100565946900_bib8","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/thx.2005.040527","article-title":"Severe acute exacerbations and mortality in patients with obstructive pulmonary disease","volume":"60","author":"Soler-Catalu\u00f1a","year":"2005","journal-title":"Thorax"},{"key":"2026032100565946900_bib9","first-page":"681","article-title":"Long-term domiciliary oxygen therapy in chronic cor pulmonale complicating chronic bronchitis and emphysema","volume":"1","author":"Medical Research Council Working Party","year":"1981","journal-title":"Lancet"},{"key":"2026032100565946900_bib10","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1378\/chest.123.5.1460","article-title":"Prognostic value of nutritional depletion in patients with COPD treated by long-term oxygen therapy: data from the ANTADIR observatory","volume":"123","author":"Chailleux","year":"2003","journal-title":"Chest"},{"key":"2026032100565946900_bib11","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1164\/rccm.200407-867OC","article-title":"Inspiratory-to-total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease","volume":"171","author":"Casanova","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100565946900_bib12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1378\/chest.99.1.112","article-title":"Elevated pulmonary artery pressure","volume":"99","author":"Cooper","year":"1991","journal-title":"Chest"},{"key":"2026032100565946900_bib13","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1164\/rccm.200605-713OC","article-title":"C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease","volume":"175","author":"Dahl","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100565946900_bib14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0300-2896(08)70441-1","article-title":"Update on the mechanisms of muscle disfunction in COPD","volume":"44","author":"Gea","year":"2008","journal-title":"Arch Bronconeumol"},{"key":"2026032100565946900_bib15","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1378\/chest.08-0776","article-title":"Bronchiectasis","volume":"134","author":"O\u2019Donnell","year":"2008","journal-title":"Chest"},{"key":"2026032100565946900_bib16","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/MCP.0b013e328312ed8c","article-title":"Update on non-cystic fibrosis bronchiectasis","volume":"14","author":"Bilton","year":"2008","journal-title":"Curr Opin Pulm Med"},{"key":"2026032100565946900_bib17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1164\/rccm.200305-648OC","article-title":"Bronchiectasis, exacerbations indices, and inflammation in chronic obstructive pulmonary disease","volume":"170","author":"Patel","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100565946900_bib18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1136\/thorax.55.8.635","article-title":"Physiological and radiological characterisation of patients diagnosed with chronic obstructive pulmonary disease in primary care","volume":"55","author":"O\u2019Brien","year":"2000","journal-title":"Thorax"},{"key":"2026032100565946900_bib19","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1183\/09031936.00003309","article-title":"Pseudomonas aeruginosa in patients hospitalised for COPD exacerbations: a prospective study","volume":"34","author":"Garcia Vidal","year":"2009","journal-title":"Eur Respir J"},{"key":"2026032100565946900_bib20","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1164\/rccm.200912-1843CC","article-title":"Chronic obstructive pulmonary disease phenotypes. The future of COPD","volume":"182","author":"Han","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100565946900_bib21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00004728-198206000-00001","article-title":"Computed tomography of bronchiectasis","volume":"6","author":"Naidich","year":"1982","journal-title":"J Comput Assist Tomogr"},{"key":"2026032100565946900_bib22","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1157\/13128330","article-title":"Normativa sobre el diagn\u00f3stico y tratamiento de las bronquiectasias","volume":"44","author":"Vendrell","year":"2008","journal-title":"Arch Bronconeumol"},{"key":"2026032100565946900_bib23","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/thx.2010.136119","article-title":"British thoracic society guideline for non-CF bronchiectasis","volume":"65","author":"Pasteur","year":"2010","journal-title":"Thorax"},{"key":"2026032100565946900_bib24","author":"Global Initiative for Chronic Obstructive Lung Disease"},{"key":"2026032100565946900_bib25","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1148\/radiology.188.3.8351357","article-title":"Uncomplicated asthma in adults: comparison of CT appearances of the lungs in asthma and healthy subjects","volume":"188","author":"Lynch","year":"1993","journal-title":"Radiology"},{"key":"2026032100565946900_bib26","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1148\/radiology.179.3.2027992","article-title":"Cystic fibrosis: scoring system with thin-section CT","volume":"179","author":"Bhalla","year":"1991","journal-title":"Radiology"},{"key":"2026032100565946900_bib27","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1136\/thx.54.7.581","article-title":"Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease","volume":"54","author":"Bestall","year":"1999","journal-title":"Thorax"},{"key":"2026032100565946900_bib28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"2026032100565946900_bib29","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0300-2896(15)31728-2","article-title":"Normativas para la pr\u00e1ctica de la espirometr\u00eda forzada","volume":"25","author":"Sanchis","year":"1989","journal-title":"Arch Bronconeumol"},{"key":"2026032100565946900_bib30","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1378\/chest.10-1758","article-title":"Factors associated with bronchiectasis in chronic obstructive pulmonary disease patients","volume":"140","author":"Mart\u00ednez-Garc\u00eda","year":"2011","journal-title":"Chest"},{"key":"2026032100565946900_bib31","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1164\/rccm.200403-354OC","article-title":"Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease","volume":"170","author":"Murphy","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100565946900_bib32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1164\/rccm.200412-1687OC","article-title":"Haemophilus influenzae from patients with chronic obstructive pulmonary disease exacerbation induce more inflammation than colonizers","volume":"172","author":"Chin","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100565946900_bib33","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1056\/NEJMoa012561","article-title":"New strains of bacteria and exacerbation of chronic obstructive pulmonary disease","volume":"347","author":"Sethi","year":"2002","journal-title":"N Engl J Med"},{"key":"2026032100565946900_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-2896(05)70731-6","article-title":"Tratamiento antimicrobiano frente a la colonizaci\u00f3n pulmonar por Pseudomonas aeruginosa en el paciente con fibrosis qu\u00edstica","volume":"41","author":"Cant\u00f3n","year":"2005","journal-title":"Arch Bronconeumol"},{"key":"2026032100565946900_bib35","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1034\/j.1399-3003.1999.13b21.x","article-title":"Predisposing factors to bacterial colonization in chronic obstructive pulmonary disease","volume":"13","author":"Zalacain","year":"1999","journal-title":"Eur Respir J"},{"key":"2026032100565946900_bib36","first-page":"6","article-title":"Inflammation: a two-edged sword-the model of bronchiectasis","volume":"147","author":"Cole","year":"1986","journal-title":"Eur J Respir Dis Suppl"},{"key":"2026032100565946900_bib37","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.rmed.2008.12.005","article-title":"Severe exacerbations and BODE index: two independent risk factors for death in male COPD patients","volume":"103","author":"Soler-Catalu\u00f1a","year":"2009","journal-title":"Respir Med"},{"key":"2026032100565946900_bib38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1465-9921-11-10","article-title":"Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial","volume":"11","author":"Sethi","year":"2010","journal-title":"Respir Res"},{"key":"2026032100565946900_bib39","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1164\/ajrccm.162.2.9910086","article-title":"Tobramycin solution for inhalation reduces sputum Pseudomonas aeruginosa density in bronchiectasis","volume":"162","author":"Barker","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100565946900_bib40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1345\/aph.1E099","article-title":"Inhaled tobramycin in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection with Pseudomonas aeruginosa","volume":"39","author":"Drobnic","year":"2005","journal-title":"Ann Pharmacother"},{"key":"2026032100565946900_bib41","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0954-6111(99)90090-2","article-title":"Inhaled antibiotic therapy in noncystic fibrosis patients with bronchiectasis and chronic bronchial infection by Pseudomonas aeruginosa","volume":"93","author":"Orriols","year":"1999","journal-title":"Respir Med"},{"key":"2026032100565946900_bib42","doi-asserted-by":"crossref","first-page":"114S","DOI":"10.1378\/chest.120.3_suppl.114S","article-title":"Treatment with tobramycin solution for inhalation in bronchiectasis patients with Pseudomonas aeruginosa","volume":"120","author":"Couch","year":"2001","journal-title":"Chest"},{"key":"2026032100565946900_bib43","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.rmed.2010.04.021","article-title":"Airway dimensions in COPD: relationship with clinical variables","volume":"104","author":"Mair","year":"2010","journal-title":"Respir Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/187\/8\/823\/67291888\/ajrccm_187_8_823.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/187\/8\/823\/67291888\/ajrccm_187_8_823.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:57:09Z","timestamp":1774069029000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/187\/8\/823\/8510228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":43,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,4,15]]},"published-print":{"date-parts":[[2013,4,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201208-1518oc","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717977357.793480266","asserted-by":"object"}]},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,4]]},"published":{"date-parts":[[2013,4]]}}}