{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:41:54Z","timestamp":1774078914060,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,15]]},"DOI":"10.1164\/rccm.201302-0203ed","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T20:04:55Z","timestamp":1366056295000},"page":"786-788","source":"Crossref","is-referenced-by-count":13,"title":["Bronchiectasis with Chronic Obstructive Pulmonary Disease"],"prefix":"10.1093","volume":"187","author":[{"given":"Robert A.","family":"Stockley","sequence":"first","affiliation":[{"name":"Lung Function and Sleep Department, University Hospital Birmingham, Edgbaston, Birmingham, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"2026032100573047800_bib1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1164\/arrd.1977.116.3.469","article-title":"The induction of pulmonary emphysema with human leukocyte elastase","volume":"116","author":"Senior","year":"1977","journal-title":"Am Rev Respir Dis"},{"key":"2026032100573047800_bib2","first-page":"372","article-title":"The induction of emphysema with elastase. II: changes in connective tissue","volume":"34","author":"Kuhn","year":"1976","journal-title":"Lab Invest"},{"key":"2026032100573047800_bib3","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1172\/JCI112600","article-title":"Immunolocalization of elastase in human emphysematous lungs","volume":"78","author":"Damiano","year":"1986","journal-title":"J Clin Invest"},{"key":"2026032100573047800_bib4","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.rmed.2005.09.024","article-title":"Effect of expectoration on inflammation in induced sputum in \u03b1-1-antitrypsin deficiency","volume":"100","author":"Gompertz","year":"2006","journal-title":"Respir Med"},{"key":"2026032100573047800_bib5","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/thorax.57.10.847","article-title":"Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease","volume":"57","author":"Donaldson","year":"2002","journal-title":"Thorax"},{"key":"2026032100573047800_bib6","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1183\/09031936.01.99114901","article-title":"Changes in bronchial inflammation during acute exacerbations of chronic bronchitis","volume":"17","author":"Gompertz","year":"2001","journal-title":"Eur Respir J"},{"key":"2026032100573047800_bib7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/15412550500346477","article-title":"Exacerbations of COPD diagnosed in primary care: Changes in spirometry and relationship to symptoms","volume":"2","author":"White","year":"2005","journal-title":"COPD"},{"key":"2026032100573047800_bib8","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1164\/ajrccm.153.6.8665038","article-title":"Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. The Lung Health Study Research Group","volume":"153","author":"Tashkin","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100573047800_bib9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.7326\/0003-4819-106-2-196","article-title":"Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease","volume":"106","author":"Anthonisen","year":"1987","journal-title":"Ann Intern Med"},{"key":"2026032100573047800_bib10","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1164\/rccm.200801-145OC","article-title":"Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations","volume":"178","author":"Seemungal","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100573047800_bib11","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1378\/chest.08-2062","article-title":"Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects","volume":"135","author":"Burgel","year":"2009","journal-title":"Chest"},{"key":"2026032100573047800_bib12","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1136\/thorax.57.9.759","article-title":"Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations","volume":"57","author":"Patel","year":"2002","journal-title":"Thorax"},{"key":"2026032100573047800_bib13","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0002-9343(00)00507-6","article-title":"Association between airway bacterial load and markers of inflammation in patients with stable chronic bronchitis","volume":"109","author":"Hill","year":"2000","journal-title":"Am J Med"},{"key":"2026032100573047800_bib14","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1136\/thx.51.9.914","article-title":"Chronic sputum production: correlations between clinical features and findings on high resolution computed tomographic scanning of the chest","volume":"51","author":"Smith","year":"1996","journal-title":"Thorax"},{"key":"2026032100573047800_bib15","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1136\/thorax.55.8.635","article-title":"Physiological and radiological characterisation of patients diagnosed with chronic obstructive pulmonary disease in primary care","volume":"55","author":"O\u2019Brien","year":"2000","journal-title":"Thorax"},{"key":"2026032100573047800_bib16","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1164\/rccm.200703-489OC","article-title":"Prevalence and impact of bronchiectasis in \u03b11-antitrypsin deficiency","volume":"176","author":"Parr","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100573047800_bib17","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1164\/rccm.201208-1518OC","article-title":"Prognostic value of bronchiectasis in patients with moderate-to-severe chronic obstructive pulmonary disease","volume":"187","author":"Mart\u00ednez-Garc\u00eda","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100573047800_bib18","article-title":"Lung function indices for predicting mortality in chronic obstructive pulmonary disease","author":"Boutou","journal-title":"Eur Respir J"},{"key":"2026032100573047800_bib19","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1164\/rccm.201203-0487OC","article-title":"Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis","volume":"186","author":"Chalmers","year":"2012","journal-title":"Am J Respir Crit Care Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/187\/8\/786\/67292037\/ajrccm_187_8_786.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/187\/8\/786\/67292037\/ajrccm_187_8_786.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:57:40Z","timestamp":1774069060000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/187\/8\/786\/8510246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":19,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,4,15]]},"published-print":{"date-parts":[[2013,4,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201302-0203ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,4]]},"published":{"date-parts":[[2013,4]]}}}