{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:44:36Z","timestamp":1792651476354,"version":"4.5.0"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Real-time endobronchial ultrasound\u2013guided transbronchial needle aspiration (EBUS-TBNA) is an established technique for invasive mediastinal staging of non\u2013small cell lung cancer (NSCLC). Needle-based techniques are now recommended as a first-line diagnostic modality for mediastinal staging. Accurate performance of systematic staging with EBUS-TBNA requires a detailed knowledge of mediastinal anatomy. This examination begins at the N3 lymph nodes, progressing through the N2 and N1 lymph node stations, unless a higher station lymph node is positive for malignant cells by rapid on-site cytologic examination. Objective methods of identifying EBUS-TBNA targets include sampling any lymph node station with a visible lymph node or with a lymph node greater than 5 mm in short axis. Three passes per station or the use of rapid on-site cytologic examination with identification of diagnostic material (tumor or lymphocytes) up to five passes are well-established techniques. Obtaining sufficient tissue for molecular profiling may require performing more than three passes. The operating characteristics of EBUS-TBNA are similar to mediastinoscopy. However, mediastinoscopy should be considered in the setting of a negative EBUS-TBNA and a high posterior probability of N2 or N3 involvement.<\/jats:p>","DOI":"10.1164\/rccm.201311-2007ci","type":"journal-article","created":{"date-parts":[[2014,3,15]],"date-time":"2014-03-15T17:28:18Z","timestamp":1394904498000},"page":"640-649","source":"Crossref","is-referenced-by-count":106,"title":["Endobronchial Ultrasound\u2013guided Transbronchial Needle Aspiration for Non\u2013Small Cell Lung Cancer Staging"],"prefix":"10.1093","volume":"189","author":[{"given":"C. Matthew","family":"Kinsey","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care, University of Vermont College of Medicine, Burlington, Vermont; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Arenberg","sequence":"additional","affiliation":[{"name":"University of Michigan Health System, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,3,15]]},"reference":[{"key":"2026032100382581500_bib1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1378\/chest.12-0212","article-title":"Training for linear endobronchial ultrasound among US pulmonary\/critical care fellowships: a survey of fellowship directors","volume":"143","author":"Tanner","year":"2013","journal-title":"Chest"},{"key":"2026032100382581500_bib2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1164\/ajrccm.156.1.ats156.1","article-title":"Pretreatment 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