{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:02:33Z","timestamp":1774119753903,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"DOI":"10.1164\/rccm.201312-2240ed","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T21:24:10Z","timestamp":1392240250000},"page":"247-249","source":"Crossref","is-referenced-by-count":4,"title":["Fat and Cardiotoxicity in Hereditary Pulmonary Hypertension"],"prefix":"10.1093","volume":"189","author":[{"given":"Rubin M.","family":"Tuder","sequence":"first","affiliation":[{"name":"Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian B.","family":"Graham","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,2,1]]},"reference":[{"key":"2026032100361647100_bib1","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1161\/CIRCULATIONAHA.106.632208","article-title":"Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure","volume":"114","author":"Voelkel","year":"2006","journal-title":"Circulation"},{"key":"2026032100361647100_bib2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1164\/rccm.201201-0164OC","article-title":"Modern age pathology of pulmonary arterial hypertension","volume":"186","author":"Stacher","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100361647100_bib3","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1164\/rccm.201003-0335OC","article-title":"Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats","volume":"182","author":"Bogaard","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100361647100_bib4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/BF02938351","article-title":"Right ventricular failure complicating heart failure: pathophysiology, significance, and management strategies","volume":"9","author":"Mahmud","year":"2007","journal-title":"Curr Cardiol Rep"},{"key":"2026032100361647100_bib5","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s00109-010-0679-1","article-title":"Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure","volume":"88","author":"Piao","year":"2010","journal-title":"J Mol Med (Berl)"},{"key":"2026032100361647100_bib6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/CIRCHEARTFAILURE.111.966127","article-title":"Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension","volume":"6","author":"Gomez-Arroyo","year":"2013","journal-title":"Circ Heart Fail"},{"key":"2026032100361647100_bib7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1164\/rccm.201306-1086OC","article-title":"Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension","volume":"189","author":"Hemnes","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100361647100_bib8","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cmet.2012.04.006","article-title":"Lipid metabolism and toxicity in the heart","volume":"15","author":"Goldberg","year":"2012","journal-title":"Cell Metab"},{"key":"2026032100361647100_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/79226","article-title":"Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension","volume":"26","author":"Lane","year":"2000","journal-title":"Nat Genet"},{"key":"2026032100361647100_bib10","doi-asserted-by":"crossref","first-page":"L744","DOI":"10.1152\/ajplung.90255.2008","article-title":"Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions","volume":"295","author":"West","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026032100361647100_bib11","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/dbio.2000.9802","article-title":"BMP signaling is required for heart formation in vertebrates","volume":"224","author":"Shi","year":"2000","journal-title":"Dev Biol"},{"key":"2026032100361647100_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ydbio.2009.04.032","article-title":"BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis","volume":"331","author":"Beppu","year":"2009","journal-title":"Dev Biol"},{"key":"2026032100361647100_bib13","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1161\/hc3201.094152","article-title":"Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins","volume":"104","author":"Morrell","year":"2001","journal-title":"Circulation"},{"key":"2026032100361647100_bib14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cyto.2012.07.013","article-title":"Transforming growth factor beta-1 and incidence of heart failure in older adults: the Cardiovascular Health Study","volume":"60","author":"Glazer","year":"2012","journal-title":"Cytokine"},{"key":"2026032100361647100_bib15","doi-asserted-by":"crossref","first-page":"e000317","DOI":"10.1161\/JAHA.113.000317","article-title":"Chronic heart failure is associated with transforming growth factor beta-dependent yield and functional decline in atrial explant-derived c-Kit+ cells","volume":"2","author":"Zakharova","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"2026032100361647100_bib16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0008-6363(99)00263-1","article-title":"Cardiac fatty acid uptake and transport in health and disease","volume":"45","author":"van der Vusse","year":"2000","journal-title":"Cardiovasc Res"},{"key":"2026032100361647100_bib17","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1164\/rccm.201108-1536PP","article-title":"Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension","volume":"185","author":"Tuder","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100361647100_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1320.001","article-title":"The role of the carnitine system in human metabolism","volume":"1033","author":"Foster","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"2026032100361647100_bib19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1172\/JCI0214080","article-title":"The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus","volume":"109","author":"Finck","year":"2002","journal-title":"J Clin Invest"},{"key":"2026032100361647100_bib20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1161\/01.RES.0000154079.20681.B9","article-title":"Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy","volume":"96","author":"Chiu","year":"2005","journal-title":"Circ Res"},{"key":"2026032100361647100_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0065-3101(24)00155-5","article-title":"New genetic defects in mitochondrial fatty acid oxidation and carnitine deficiency","volume":"34","author":"Stanley","year":"1987","journal-title":"Adv Pediatr"},{"key":"2026032100361647100_bib22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1152\/physrev.00017.2007","article-title":"Cardiac remodeling in obesity","volume":"88","author":"Abel","year":"2008","journal-title":"Physiol Rev"},{"key":"2026032100361647100_bib23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S1050-1738(02)00152-4","article-title":"Mechanisms of lipoapoptosis: implications for human heart disease","volume":"12","author":"Listenberger","year":"2002","journal-title":"Trends Cardiovasc Med"},{"key":"2026032100361647100_bib24","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nm1238","article-title":"Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice","volume":"11","author":"Petrache","year":"2005","journal-title":"Nat Med"},{"key":"2026032100361647100_bib25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11897-013-0133-0","article-title":"Cardiac lipotoxicity: molecular pathways and therapeutic implications","volume":"10","author":"Drosatos","year":"2013","journal-title":"Curr Heart Fail Rep"},{"key":"2026032100361647100_bib26","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/(SICI)1099-0895(199812)14:4<263::AID-DMR233>3.0.CO;2-C","article-title":"Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years","volume":"14","author":"Randle","year":"1998","journal-title":"Diabetes Metab Rev"},{"key":"2026032100361647100_bib27","doi-asserted-by":"crossref","first-page":"44ra58","DOI":"10.1126\/scitranslmed.3001327","article-title":"Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension","volume":"2","author":"Sutendra","year":"2010","journal-title":"Sci Transl Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/189\/3\/247\/67239305\/ajrccm_189_3_247.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/189\/3\/247\/67239305\/ajrccm_189_3_247.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:37:27Z","timestamp":1774067847000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/189\/3\/247\/8506183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,1]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,2,1]]},"published-print":{"date-parts":[[2014,2,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201312-2240ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,2]]},"published":{"date-parts":[[2014,2,1]]}}}