{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:32:53Z","timestamp":1774078373011,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"DOI":"10.1164\/rccm.201401-0129ed","type":"journal-article","created":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T23:24:31Z","timestamp":1393716271000},"page":"510-511","source":"Crossref","is-referenced-by-count":4,"title":["Lung Clearance Index. A Potential Quantitative Tool to Assess Treatment Response in Bronchiectasis?"],"prefix":"10.1093","volume":"189","author":[{"given":"Adam T.","family":"Hill","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Royal Infirmary and University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick A.","family":"Flume","sequence":"additional","affiliation":[{"name":"Department of Medicine and Pediatrics, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"2026032100334965800_bib1","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/thx.2010.136119","article-title":"British Thoracic Society guideline for non-CF bronchiectasis","volume":"65","author":"Pasteur","year":"2010","journal-title":"Thorax"},{"key":"2026032100334965800_bib2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ccm.2012.03.001","article-title":"Evaluating success of therapy for bronchiectasis: what end points to use?","volume":"33","author":"Smith","year":"2012","journal-title":"Clin Chest Med"},{"key":"2026032100334965800_bib3","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1164\/rccm.201207-1160OE","article-title":"Cystic fibrosis pulmonary guidelines. Chronic medications for maintenance of lung health","volume":"187","author":"Mogayzel","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100334965800_bib4","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1183\/09031936.00122508","article-title":"Assessing response to treatment of exacerbations of bronchiectasis in adults","volume":"33","author":"Murray","year":"2009","journal-title":"Eur Respir J"},{"key":"2026032100334965800_bib5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1164\/rccm.201005-0756OC","article-title":"A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis","volume":"183","author":"Murray","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100334965800_bib6","first-page":"1420","article-title":"A pilot study of the safety and efficacy of tobramycin solution for inhalation in patients with severe bronchiectasis","volume":"127","author":"Scheinberg","year":"2005","journal-title":"Chest"},{"key":"2026032100334965800_bib7","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0140-6736(12)60953-2","article-title":"Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial","volume":"380","author":"Wong","year":"2012","journal-title":"Lancet"},{"key":"2026032100334965800_bib8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1378\/chest.12-1763","article-title":"Phase 3 randomized study of the efficacy and safety of inhaled dry powder mannitol for the symptomatic treatment of non-cystic fibrosis bronchiectasis","volume":"144","author":"Bilton","year":"2013","journal-title":"Chest"},{"key":"2026032100334965800_bib9","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1148\/radiology.179.3.2027992","article-title":"Cystic fibrosis: scoring system with thin-section CT","volume":"179","author":"Bhalla","year":"1991","journal-title":"Radiology"},{"key":"2026032100334965800_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/thx.2007.082628","article-title":"Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis","volume":"63","author":"Horsley","year":"2008","journal-title":"Thorax"},{"key":"2026032100334965800_bib11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/thx.2007.077784","article-title":"Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis","volume":"63","author":"Gustafsson","year":"2008","journal-title":"Thorax"},{"key":"2026032100334965800_bib12","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1164\/rccm.201310-1747OC","article-title":"Lung clearance index is a repeatable and sensitive indicator of radiological changes in bronchiectasis","volume":"189","author":"Rowan","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100334965800_bib13","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1164\/rccm.201304-0800OC","article-title":"Lung clearance index and high-resolution computed tomography scores in primary ciliary dyskinesia","volume":"188","author":"Irving","year":"2013","journal-title":"Am J Respir Crit Care Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/189\/5\/510\/67238146\/ajrccm_189_5_510.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/189\/5\/510\/67238146\/ajrccm_189_5_510.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:34:31Z","timestamp":1774067671000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/189\/5\/510\/8506082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,1]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,3,1]]},"published-print":{"date-parts":[[2014,3,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201401-0129ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,3]]},"published":{"date-parts":[[2014,3,1]]}}}