{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:29:48Z","timestamp":1774078188336,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,1]]},"DOI":"10.1164\/rccm.201408-1480le","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T15:55:16Z","timestamp":1422633316000},"page":"352-355","source":"Crossref","is-referenced-by-count":3,"title":["<i>Tuberous Sclerosis Complex 2<\/i>\n                    Loss of Heterozygosity in Patients with Lung Disease and Cancer"],"prefix":"10.1093","volume":"191","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"National Heart, Lung, and Blood Institute, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Pacheco-Rodriguez","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy K.","family":"Steagall","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Kato","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Haughey","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph R.","family":"Fontana","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent C.","family":"Manganiello","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Moss","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,2,1]]},"reference":[{"key":"2026032100242782300_bib1","first-page":"276","article-title":"Lymphangioleiomyomatosis","volume":"13","author":"Taveira-DaSilva","year":"2006","journal-title":"Cancer Contr"},{"key":"2026032100242782300_bib2","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1056\/NEJMra055323","article-title":"The tuberous sclerosis complex","volume":"355","author":"Crino","year":"2006","journal-title":"N Engl J Med"},{"key":"2026032100242782300_bib3","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1056\/NEJMoa1100391","article-title":"Efficacy and safety of sirolimus in lymphangioleiomyomatosis","volume":"364","author":"McCormack","year":"2011","journal-title":"N Engl J Med"},{"key":"2026032100242782300_bib4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/gcc.10252","article-title":"Metastasis of benign tumor cells in tuberous sclerosis complex","volume":"38","author":"Henske","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"2026032100242782300_bib5","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1172\/JCI58709","article-title":"Lymphangioleiomyomatosis - a wolf in sheep\u2019s clothing","volume":"122","author":"Henske","year":"2012","journal-title":"J Clin Invest"},{"key":"2026032100242782300_bib6","doi-asserted-by":"crossref","first-page":"17462","DOI":"10.1073\/pnas.0407971101","article-title":"Molecular and genetic analysis of disseminated neoplastic cells in lymphangioleiomyomatosis","volume":"101","author":"Crooks","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026032100242782300_bib7","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1164\/rccm.201003-0489OC","article-title":"Phenotypic characterization of disseminated cells with TSC2 loss of heterozygosity in patients with lymphangioleiomyomatosis","volume":"182","author":"Cai","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100242782300_bib8","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1073\/pnas.97.11.6085","article-title":"Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis","volume":"97","author":"Carsillo","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026032100242782300_bib9","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1164\/ajrccm.160.5.9903146","article-title":"Microsatellite DNA instability and loss of heterozygosity in pulmonary sarcoidosis","volume":"160","author":"Vassilakis","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100242782300_bib10","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.humpath.2003.07.014","article-title":"Genotypic analysis of pulmonary Langerhans cell histiocytosis","volume":"34","author":"Dacic","year":"2003","journal-title":"Hum Pathol"},{"key":"2026032100242782300_bib11","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.rmed.2005.05.015","article-title":"Microsatellite DNA instability in benign lung diseases","volume":"100","author":"Samara","year":"2006","journal-title":"Respir Med"},{"key":"2026032100242782300_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1378\/chest.116.1.47","article-title":"Microsatellite DNA instability in COPD","volume":"116","author":"Siafakas","year":"1999","journal-title":"Chest"},{"key":"2026032100242782300_bib13","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1183\/09031936.03.00010503","article-title":"Microsatellite DNA instability and loss of heterozygosity in bronchial asthma","volume":"22","author":"Paraskakis","year":"2003","journal-title":"Eur Respir J"},{"key":"2026032100242782300_bib14"},{"key":"2026032100242782300_bib15","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/jnci\/89.21.1563","article-title":"Cigarettes, sex, and lung adenocarcinoma","volume":"89","author":"Gazdar","year":"1997","journal-title":"J Natl Cancer Inst"},{"key":"2026032100242782300_bib16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF01366952","article-title":"Hereditary cancer: two hits revisited","volume":"122","author":"Knudson","year":"1996","journal-title":"J Cancer Res Clin Oncol"},{"key":"2026032100242782300_bib17"},{"key":"2026032100242782300_bib18","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/S0002-9440(10)63041-6","article-title":"Loss of heterozygosity on chromosomes 9q and 16p in atypical adenomatous hyperplasia concomitant with adenocarcinoma of the lung","volume":"159","author":"Takamochi","year":"2001","journal-title":"Am J Pathol"},{"key":"2026032100242782300_bib19","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s004390000390","article-title":"Molecular analysis of the TSC1 and TSC2 tumour suppressor genes in sporadic glial and glioneuronal tumours","volume":"107","author":"Parry","year":"2000","journal-title":"Hum Genet"},{"key":"2026032100242782300_bib20","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1054\/bjoc.2001.2072","article-title":"Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas","volume":"85","author":"Parry","year":"2001","journal-title":"Br J Cancer"},{"key":"2026032100242782300_bib21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/1471-2407-8-163","article-title":"Involvement of TSC genes and differential expression of other members of the mTOR signaling pathway in oral squamous cell carcinoma","volume":"8","author":"Chakraborty","year":"2008","journal-title":"BMC Cancer"},{"key":"2026032100242782300_bib22","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/bjc.1996.75","article-title":"High frequency of chromosome 9 deletion in ovarian cancer: evidence for three tumour-suppressor loci","volume":"73","author":"Devlin","year":"1996","journal-title":"Br J Cancer"},{"key":"2026032100242782300_bib23","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/gcc.2870130411","article-title":"Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band 16p13 occurs in sporadic as well as TSC-associated renal angiomyolipomas","volume":"13","author":"Henske","year":"1995","journal-title":"Genes Chromosomes Cancer"},{"key":"2026032100242782300_bib24","first-page":"1671","article-title":"Detailed deletion mapping of chromosome 9q in bladder cancer: evidence for two tumour suppressor loci","volume":"11","author":"Habuchi","year":"1995","journal-title":"Oncogene"},{"key":"2026032100242782300_bib25","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0046-8177(98)90422-1","article-title":"LOH at 16p13 is a novel chromosomal alteration detected in benign and malignant microdissected papillary neoplasms of the breast","volume":"29","author":"Lininger","year":"1998","journal-title":"Hum Pathol"},{"key":"2026032100242782300_bib26","first-page":"400","article-title":"Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions","volume":"59","author":"Henske","year":"1996","journal-title":"Am J Hum Genet"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/191\/3\/352\/67217734\/ajrccm_191_3_352.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/191\/3\/352\/67217734\/ajrccm_191_3_352.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:24:37Z","timestamp":1774067077000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/191\/3\/352\/8505208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,1]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,2,1]]},"published-print":{"date-parts":[[2015,2,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201408-1480le","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,2]]},"published":{"date-parts":[[2015,2,1]]}}}