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Although lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis are perhaps more frequently seen in the clinic, disorders such as Birt-Hogg-Dub\u00e9 syndrome, lymphocytic interstitial pneumonia, follicular bronchiolitis, and light-chain deposition disease are increasingly being recognized. Obtaining an accurate diagnosis can be challenging, and management approaches are highly disease dependent. Unique imaging features, genetic tests, serum studies, and clinical features provide invaluable clues that help clinicians distinguish among the various etiologies, but biopsy is often required for definitive diagnosis. In part II of this review, we present an overview of the diffuse cystic lung diseases caused by lymphoproliferative disorders, genetic mutations, or aberrant lung development and provide an approach to aid in their diagnosis and management.<\/jats:p>","DOI":"10.1164\/rccm.201411-2096ci","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T13:02:19Z","timestamp":1429794139000},"page":"17-29","source":"Crossref","is-referenced-by-count":143,"title":["Diffuse Cystic Lung Disease. Part II"],"prefix":"10.1093","volume":"192","author":[{"given":"Nishant","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine and"},{"name":"Veterans Affairs Medical Center, Department of Veterans Affairs, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Vassallo","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Wikenheiser-Brokamp","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio"},{"name":"Division of Pathology and Laboratory Medicine and"},{"name":"Division of Pulmonary Biology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis X.","family":"McCormack","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine and"},{"name":"Veterans Affairs Medical Center, Department of Veterans Affairs, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"2026032100133134100_bib1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/jmg.2009.070565","article-title":"Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and\/or multiple lung cysts are the presenting feature","volume":"47","author":"Kunogi","year":"2010","journal-title":"J Med Genet"},{"key":"2026032100133134100_bib2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/jmg.2007.049874","article-title":"Mutations of the Birt Hogg Dube gene in patients with multiple lung cysts and 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