{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:09:13Z","timestamp":1787695753933,"version":"build-2784847793"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sepsis and acute kidney injury (AKI) represent an important burden in intensive care unit clinical practices. The Journal published important contributions in sepsis for novel therapeutic approaches suggesting that combined molecular targets (e.g., dual inhibition of IL-1\u03b2 and IL-18, and coadministration of endothelial progenitor cells and stromal cell\u2013derived factor-1\u03b1 analog) could perform better. The clinical effectiveness of 1,25-dihydroxyvitamin D was reported in a double-blind, randomized, placebo-controlled trial. Although its experimental properties appeared favorable in the pro- and antiinflammatory cytokine balance, 1,25-dihydroxyvitamin D failed to improve survival. Strategies for decreasing antimicrobial resistances are of particular importance. Effective (aerosolized antibiotics for ventilator-associated pneumonia) and ineffective (procalcitonin algorithm for antibiotic deescalation) approaches were published. In 2014, several publications raised an important point shared by survivors from sepsis and\/or AKI. The increased number of survivors over time brought out long-term sequelae, leading to a poor outcome after hospital discharge. Among them, cardiovascular events and chronic kidney disease may explain the significant increase in the risk of death, which can persist up to 10 years and significantly increases the use of health care. Postdischarge survival represents a new target for future research in sepsis and AKI to find how we can prevent and manage long-term sequelae. A milestone of the year was the Ebola outbreak. The Journal contributed to our better understanding of Ebola virus disease with a paper underlying the crucial role of a large implementation of pragmatic supportive care, including fluid infusion and correction of metabolic abnormalities, to save more lives.<\/jats:p>","DOI":"10.1164\/rccm.201502-0307up","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T08:57:26Z","timestamp":1433235446000},"page":"1226-1231","source":"Crossref","is-referenced-by-count":24,"title":["Update in Sepsis and Acute Kidney Injury 2014"],"prefix":"10.1093","volume":"191","author":[{"given":"Fr\u00e9d\u00e9rique","family":"Schortgen","sequence":"first","affiliation":[{"name":"R\u00e9animation M\u00e9dicale, Groupe Hospitalier Henri Mondor, AP-HP, Cr\u00e9teil, France"},{"name":"INSERM, U955, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Est, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Asfar","sequence":"additional","affiliation":[{"name":"D\u00e9partement de R\u00e9animation M\u00e9dicale et de M\u00e9decine Hyperbare Centre Hospitalier Universitaire Angers, Pres L'Unam, France; and"},{"name":"Laboratoire de Biologie Neurovasculaire et Mitochondriale Int\u00e9gr\u00e9e, CNRS UMR 6214\u2013INSERM U1083, Universit\u00e9 Angers, Pres L'Unam, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"2026032100203298300_bib1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1164\/rccm.201308-1535OC","article-title":"Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock","volume":"189","author":"Vanden Berghe","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100203298300_bib2","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1164\/rccm.201403-0586OC","article-title":"A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock","volume":"190","author":"Meyer","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100203298300_bib3","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1164\/rccm.201307-1358OC","article-title":"Pseudomonas aeruginosa type-3 secretion system dampens host defense by exploiting the NLRC4-coupled inflammasome","volume":"189","author":"Faure","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100203298300_bib4","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1164\/rccm.201312-2163OC","article-title":"Endothelial progenitor cells and a stromal cell-derived factor-1\u03b1 analogue synergistically improve survival in sepsis","volume":"189","author":"Fan","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100203298300_bib5","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1164\/rccm.201405-0988OC","article-title":"Randomized controlled trial of calcitriol in severe sepsis","volume":"190","author":"Leaf","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100203298300_bib6","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1001\/jama.2014.13204","article-title":"Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial","volume":"312","author":"Amrein","year":"2014","journal-title":"JAMA"},{"key":"2026032100203298300_bib7","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1164\/rccm.201401-0171OC","article-title":"Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock","volume":"189","author":"Wong","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100203298300_bib8","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1001\/jama.2013.280031","article-title":"Effect of statin therapy on mortality in patients with ventilator-associated pneumonia: a randomized clinical trial","volume":"310","author":"Papazian","year":"2013","journal-title":"JAMA"},{"key":"2026032100203298300_bib9","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1056\/NEJMoa1401520","article-title":"Rosuvastatin for sepsis-associated acute respiratory distress syndrome","volume":"370","author":"Truwit","year":"2014","journal-title":"N Engl J Med"},{"key":"2026032100203298300_bib10","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.molmed.2014.01.002","article-title":"The new normal: immunomodulatory agents against sepsis immune suppression","volume":"20","author":"Hutchins","year":"2014","journal-title":"Trends Mol Med"},{"key":"2026032100203298300_bib11","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1164\/rccm.201301-0036CP","article-title":"Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. 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