{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:31:18Z","timestamp":1793730678918,"version":"4.6.1"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R01 NR011051"],"award-info":[{"award-number":["R01 NR011051"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["K24 HL089223"],"award-info":[{"award-number":["K24 HL089223"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Early physical therapy (PT) interventions may benefit patients with acute respiratory failure by preventing or attenuating neuromuscular weakness. However, the optimal dosage of these interventions is currently unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether an intensive PT program significantly improves long-term physical functional performance compared with a standard-of-care PT program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who required mechanical ventilation for at least 4 days were eligible. Enrolled patients were randomized to receive PT for up to 4 weeks delivered in an intensive or standard-of-care manner. Physical functional performance was assessed at 1, 3, and 6 months in survivors who were not currently in an acute or long-term care facility. The primary outcome was the Continuous Scale Physical Functional Performance Test short form (CS-PFP-10) score at 1 month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>A total of 120 patients were enrolled from five hospitals. Patients in the intensive PT group received 12.4\u2009\u00b1\u20096.5 sessions for a total of 408\u2009\u00b1\u2009261 minutes compared with only 6.1\u2009\u00b1\u20093.8 sessions for 86\u2009\u00b1\u200963 minutes in the standard-of-care group (P\u2009&amp;lt;\u20090.001 for both analyses). Physical function assessments were available for 86% of patients at 1 month, for 76% at 3 months, and for 60% at 6 months. In both groups, physical function was reduced yet significantly improved over time between 1, 3, and 6 months. When we compared the two interventions, we found no differences in the total CS-PFP-10 scores at all three time points (P\u2009=\u20090.73, 0.29, and 0.43, respectively) or in the total CS-PFP-10 score trajectory (P\u2009=\u20090.71).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An intensive PT program did not improve long-term physical functional performance compared with a standard-of-care program.<\/jats:p>\n                    <jats:p>Clinical trial registered with www.clinicaltrials.gov (NCT01058421).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201505-1039oc","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T12:03:57Z","timestamp":1449749037000},"page":"1101-1110","source":"Crossref","is-referenced-by-count":306,"title":["A Randomized Trial of an Intensive Physical Therapy Program for Patients with Acute Respiratory Failure"],"prefix":"10.1093","volume":"193","author":[{"given":"Marc","family":"Moss","sequence":"first","affiliation":[{"name":"Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Nordon-Craft","sequence":"additional","affiliation":[{"name":"Physical Therapy Program, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Malone","sequence":"additional","affiliation":[{"name":"Physical Therapy Program, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Van Pelt","sequence":"additional","affiliation":[{"name":"The Medical Center of Aurora, Aurora, Colorado; 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