{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:28:14Z","timestamp":1774078094924,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002g","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI057438"],"award-info":[{"award-number":["AI057438"]}],"id":[{"id":"10.13039\/100000002g","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002g","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI100799"],"award-info":[{"award-number":["AI100799"]}],"id":[{"id":"10.13039\/100000002g","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,15]]},"DOI":"10.1164\/rccm.201506-1201ed","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T12:29:02Z","timestamp":1442320142000},"page":"647-648","source":"Crossref","is-referenced-by-count":4,"title":["Chronic Rhinosinusitis: More Than Just \u201cAsthma of the Upper Airway\u201d"],"prefix":"10.1093","volume":"192","author":[{"given":"Larry","family":"Borish","sequence":"first","affiliation":[{"name":"University of Virginia Health Systems, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,9,15]]},"reference":[{"key":"2026032100175917800_bib1","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1164\/rccm.201412-2278OC","article-title":"Cytokines in chronic rhinosinusitis: role in eosinophilia and aspirin-exacerbated respiratory disease","volume":"192","author":"Stevens","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100175917800_bib2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.otohns.2004.09.067","article-title":"American Academy of Allergy, Asthma and Immunology; American Academy of Otolaryngic Allergy; American Academy of Otolaryngology-Head and Neck Surgery; American College of Allergy, Asthma and Immunology; American Rhinologic Society. Rhinosinusitis: establishing definitions for clinical research and patient care","volume":"131","author":"Meltzer","year":"2004","journal-title":"Otolaryngol Head Neck Surg"},{"key":"2026032100175917800_bib3","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1136\/thorax.55.suppl_2.S79","article-title":"Nasal polyposis, eosinophil dominated inflammation, and allergy","volume":"55","author":"Mygind","year":"2000","journal-title":"Thorax"},{"key":"2026032100175917800_bib4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mai.2001.112374","article-title":"Total and specific IgE in nasal polyps is related to local eosinophilic inflammation","volume":"107","author":"Bachert","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"2026032100175917800_bib5","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jaci.2003.08.009","article-title":"Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma?","volume":"112","author":"Ponikau","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"2026032100175917800_bib6","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200903-0392OC","article-title":"T-helper type 2-driven inflammation defines major subphenotypes of asthma","volume":"180","author":"Woodruff","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032100175917800_bib7","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jaci.2006.05.031","article-title":"Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps","volume":"118","author":"Gevaert","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"2026032100175917800_bib8","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1398-9995.2006.01225.x","article-title":"Differentiation of chronic sinus diseases by measurement of inflammatory mediators","volume":"61","author":"Van Zele","year":"2006","journal-title":"Allergy"},{"key":"2026032100175917800_bib9","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.jaci.2013.02.036","article-title":"Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology","volume":"131","author":"Akdis","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"2026032100175917800_bib10","doi-asserted-by":"crossref","first-page":"e97581","DOI":"10.1371\/journal.pone.0097581","article-title":"Mixed T helper cell signatures in chronic rhinosinusitis with and without polyps","volume":"9","author":"Derycke","year":"2014","journal-title":"PLoS One"},{"key":"2026032100175917800_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/alr.21253","article-title":"The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery","volume":"4","author":"Adappa","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"key":"2026032100175917800_bib12","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1172\/JCI72094","article-title":"Bitter and sweet taste receptors regulate human upper respiratory innate immunity","volume":"124","author":"Lee","year":"2014","journal-title":"J Clin Invest"},{"key":"2026032100175917800_bib13","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/lary.21969","article-title":"Evidence for distinct histologic profile of nasal polyps with and without eosinophilia","volume":"121","author":"Payne","year":"2011","journal-title":"Laryngoscope"},{"key":"2026032100175917800_bib14","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1172\/JCI620","article-title":"Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma","volume":"101","author":"Cowburn","year":"1998","journal-title":"J Clin Invest"},{"key":"2026032100175917800_bib15","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jaci.2004.10.051","article-title":"Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis","volume":"115","author":"Corrigan","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"2026032100175917800_bib16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jaci.2014.07.031","article-title":"Prostaglandin D\u2082: a dominant mediator of aspirin-exacerbated respiratory disease","volume":"135","author":"Cahill","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"2026032100175917800_bib17","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1182\/blood-2011-10-384826","article-title":"Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes","volume":"119","author":"Laidlaw","year":"2012","journal-title":"Blood"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/192\/6\/647\/67230014\/ajrccm_192_6_647.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/192\/6\/647\/67230014\/ajrccm_192_6_647.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:18:05Z","timestamp":1774066685000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/192\/6\/647\/8504632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,9,15]]},"published-print":{"date-parts":[[2015,9,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201506-1201ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,9]]},"published":{"date-parts":[[2015,9]]}}}