{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:46:03Z","timestamp":1793159163137,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100006501","name":"Cystic Fibrosis Foundation Therapeutics","doi-asserted-by":"publisher","award":["SLY04A0"],"award-info":[{"award-number":["SLY04A0"]}],"id":[{"id":"10.13039\/100006501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006501","name":"Cystic Fibrosis Foundation Therapeutics","doi-asserted-by":"publisher","award":["STICK09A0"],"award-info":[{"award-number":["STICK09A0"]}],"id":[{"id":"10.13039\/100006501","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Health and Medical Research Council of Australia","award":["APP513730"],"award-info":[{"award-number":["APP513730"]}]},{"name":"National Health and Medical Research Council of Australia","award":["APP1020555"],"award-info":[{"award-number":["APP1020555"]}]},{"name":"National Health and Medical Research Council of Australia","award":["1000896"],"award-info":[{"award-number":["1000896"]}]},{"name":"Institute for Respiratory Health","award":["APP1025550"],"award-info":[{"award-number":["APP1025550"]}]},{"name":"Institute for Respiratory Health","award":["APP1088389"],"award-info":[{"award-number":["APP1088389"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>The lung clearance index is a measure of ventilation distribution derived from the multiple-breath washout technique. It has been suggested as a surrogate for chest computed tomography to detect structural lung abnormalities in individuals with cystic fibrosis (CF); however, the associations between lung clearance index and early structural lung disease are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We assessed the ability of the lung clearance index to reflect structural lung disease on the basis of chest computed tomography across the entire pediatric age range.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Lung clearance index was assessed in 42 infants (ages 0\u20132 yr), 39 preschool children (ages 3\u20136 yr), and 38 school-age children (7\u201316 yr) with CF before chest computed tomography and in 72 healthy control subjects. Scans were evaluated for CF-related structural lung disease using the Perth-Rotterdam Annotated Grid Morphometric Analysis for Cystic Fibrosis quantitative outcome measure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>In infants with CF, lung clearance index is insensitive to structural disease (\u03ba\u2009=\u2009\u22120.03 [95% confidence interval, \u22120.05 to 0.16]). In preschool children with CF, lung clearance index correlates with total disease extent. In school-age children, lung clearance index correlates with extent of total disease, bronchiectasis, and air trapping. In preschool and school-age children, lung clearance index has a good positive predictive value (83\u201386%) but a poor negative predictive value (50\u201355%) to detect the presence of bronchiectasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data suggest that lung clearance index may be a useful surveillance tool to monitor structural lung disease in preschool and school-age children with CF. However, lung clearance index cannot replace chest computed tomography to screen for bronchiectasis in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201507-1409oc","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T14:55:55Z","timestamp":1441983355000},"page":"60-67","source":"Crossref","is-referenced-by-count":170,"title":["Lung Clearance Index and Structural Lung Disease on Computed Tomography in Early Cystic Fibrosis"],"prefix":"10.1093","volume":"193","author":[{"given":"Kathryn A.","family":"Ramsey","sequence":"first","affiliation":[{"name":"Telethon Kids Institute and"},{"name":"Cystic Fibrosis Research and Treatment Centre, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Rosenow","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute and"},{"name":"School of Paediatrics and Child Health, 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