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The pathogenesis of PGD involves ischemia-reperfusion injury. However, subclinical increases in pulmonary venous pressure due to left ventricular diastolic dysfunction may contribute by exacerbating capillary leak.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether a higher ratio of early mitral inflow velocity (E) to early diastolic mitral annular velocity (\u00e9), indicative of worse left ventricular diastolic function, is associated with a higher risk of PGD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study of patients in the Lung Transplant Outcomes Group who underwent bilateral lung transplant at our institution between 2004 and 2014 for interstitial lung disease, chronic obstructive pulmonary disease, or pulmonary arterial hypertension. Transthoracic echocardiograms obtained during evaluation for transplant listing were analyzed for E\/\u00e9 and other measures of diastolic function. PGD was defined as PaO2\/FiO2 less than or equal to 200 with allograft infiltrates at 48 or 72 hours after reperfusion. The association between E\/\u00e9 and PGD was assessed with multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>After adjustment for recipient age, body mass index, mean pulmonary arterial pressure, and pretransplant diagnosis, higher E\/\u00e9 and E\/\u00e9 greater than 8 were associated with an increased risk of PGD (E\/\u00e9 odds ratio, 1.93; 95% confidence interval, 1.02\u20133.64; P\u2009=\u20090.04; E\/\u00e9 &amp;gt;8 odds ratio, 5.29; 95% confidence interval, 1.40\u201320.01; P\u2009=\u20090.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Differences in left ventricular diastolic function may contribute to the development of PGD. Future trials are needed to determine whether optimization of left ventricular diastolic function reduces the risk of PGD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201508-1522oc","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T10:47:03Z","timestamp":1452250023000},"page":"1392-1400","source":"Crossref","is-referenced-by-count":71,"title":["Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction after Lung Transplant"],"prefix":"10.1093","volume":"193","author":[{"given":"Mary K.","family":"Porteous","sequence":"first","affiliation":[{"name":"Department of Medicine"},{"name":"Center for Clinical Epidemiology and Biostatistics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Ky","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"Center for Clinical Epidemiology and Biostatistics, and"},{"name":"Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Kirkpatrick","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle, Washington; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Biostatistics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Diamond","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"Center for Clinical Epidemiology and Biostatistics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupal J.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Christie","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"Center for Clinical Epidemiology and Biostatistics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Kawut","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"Center for Clinical Epidemiology and Biostatistics, and"},{"name":"Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,6,15]]},"reference":[{"key":"2026032100071816400_bib1","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.healun.2004.11.049","article-title":"Report of the ISHLT working group on primary lung graft dysfunction part II: Definition. 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