{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:22:54Z","timestamp":1774077774009,"version":"3.50.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Central airway stenosis (CAS) after lung transplantation has been attributed in part to chronic airway ischemia; however, little is known about the time course or significance of large airway hypoxia early after transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate large airway oxygenation and hypoxic gene expression during the first month after lung transplantation and their relation to airway complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subjects who underwent lung transplantation underwent endobronchial tissue oximetry of native and donor bronchi at 0, 3, and 30 days after transplantation (n\u2009=\u200911) and\/or endobronchial biopsies (n\u2009=\u200914) at 30 days for real-time polymerase chain reaction of hypoxia-inducible genes. Patients were monitored for 6 months for the development of transplant-related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Compared with native endobronchial tissues, donor tissue oxygen saturations (Sto2) were reduced in the upper lobes (74.1\u2009\u00b1\u20091.8% vs. 68.8\u2009\u00b1\u20091.7%; P\u2009&amp;lt;\u20090.05) and lower lobes (75.6\u2009\u00b1\u20091.6% vs. 71.5\u2009\u00b1\u20091.8%; P\u2009=\u20090.065) at 30 days post-transplantation. Donor upper lobe and subcarina Sto2 levels were also lower than the main carina (difference of \u22123.9\u2009\u00b1\u20091.5 and \u22124.8\u2009\u00b1\u20092.1, respectively; P\u2009&amp;lt;\u20090.05) at 30 days. Up-regulation of hypoxia-inducible genes VEGFA, FLT1, VEGFC, HMOX1, and TIE2 was significant in donor airways relative to native airways (all P\u2009&amp;lt;\u20090.05). VEGFA, KDR, and HMOX1 were associated with prolonged respiratory failure, prolonged hospitalization, extensive airway necrosis, and CAS (P\u2009&amp;lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings implicate donor bronchial hypoxia as a driving factor for post-transplantation airway complications. Strategies to improve airway oxygenation, such as bronchial artery re-anastomosis and hyperbaric oxygen therapy merit clinical investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201508-1634oc","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T13:38:28Z","timestamp":1445434708000},"page":"552-560","source":"Crossref","is-referenced-by-count":21,"title":["Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation"],"prefix":"10.1093","volume":"193","author":[{"given":"Bryan D.","family":"Kraft","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagir B.","family":"Suliman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli 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