{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:11:44Z","timestamp":1774077104556,"version":"3.50.1"},"reference-count":82,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FDM 20150734498"],"award-info":[{"award-number":["FDM 20150734498"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This review documents important progress made in 2015 in the field of critical care. Significant advances in 2015 included further evidence for early implementation of low tidal volume ventilation as well as new insights into the role of open lung biopsy, diaphragmatic dysfunction, and a potential mechanism for ventilator-induced fibroproliferation. New therapies, including a novel low-flow extracorporeal CO2 removal technique and mesenchymal stem cell\u2013derived microparticles, have also been studied. Several studies examining the role of improved diagnosis and prevention of ventilator-associated pneumonia also showed relevant results. This review examines articles published in the American Journal of Respiratory and Critical Care Medicine and other major journals that have made significant advances in the field of critical care in 2015.<\/jats:p>","DOI":"10.1164\/rccm.201602-0339up","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T10:13:27Z","timestamp":1467368007000},"page":"19-25","source":"Crossref","is-referenced-by-count":5,"title":["Update in Critical Care 2015"],"prefix":"10.1093","volume":"194","author":[{"given":"Martin","family":"Dres","sequence":"first","affiliation":[{"name":"Department of Critical Care, St. Michael\u2019s Hospital and the Critical Illness and Injury Research Centre, Keenan Research Centre for Biomedical Science of St. Michael\u2019s Hospital, Toronto, Ontario, Canada"},{"name":"Interdepartmental Division of Critical Care and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Mancebo","sequence":"additional","affiliation":[{"name":"Servei de Medicina Intensiva, Hospital de Sant Pau, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard F.","family":"Curley","sequence":"additional","affiliation":[{"name":"Department of Critical Care, St. Michael\u2019s Hospital and the Critical Illness and Injury Research Centre, Keenan Research Centre for Biomedical Science of St. Michael\u2019s Hospital, Toronto, Ontario, Canada"},{"name":"Interdepartmental Division of Critical Care and"},{"name":"Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"2026032023504538600_bib1","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1056\/NEJMoa1503326","article-title":"High-flow oxygen 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