{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:36:58Z","timestamp":1793277418010,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Pulmonx Corporation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Endobronchial valves (EBVs) have been successfully used in patients with severe heterogeneous emphysema to improve lung physiology. Limited available data suggest that EBVs are also effective in homogeneous emphysema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of EBVs in patients with homogeneous emphysema with absence of collateral ventilation assessed with the Chartis system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, multicenter, 1:1 randomized controlled trial of EBV plus standard of care (SoC) or SoC alone. Primary outcome was the percentage change in FEV1 (liters) at 3 months relative to baseline in the EBV group versus the SoC group. Secondary outcomes included changes in FEV1, St. George\u2019s Respiratory Questionnaire (SGRQ), 6-minute-walk distance (6MWD), and target lobe volume reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Ninety-three subjects (age, 63.7\u2009\u00b1\u20096.1 yr [mean\u2009\u00b1\u2009SD]; FEV1, % predicted, 29.3\u2009\u00b1\u20096.5; residual volume, % predicted, 275.4\u2009\u00b1\u200959.4) were allocated to either the EBV group (n\u2009=\u200943) or the SoC group (n\u2009=\u200950). In the intention-to-treat population, at 3 months postprocedure, improvement in FEV1 from baseline was 13.7\u2009\u00b1\u200928.2% in the EBV group and \u22123.2\u2009\u00b1\u200913.0% in the SoC group (mean between-group difference, 17.0%; P\u2009=\u20090.0002). Other variables demonstrated statistically and clinically significant changes from baseline to 3 months (EBV vs. SoC, respectively: SGRQ, \u22128.63\u2009\u00b1\u200911.25 vs. 1.01\u2009\u00b1\u20099.36; and 6MWD, 22.63\u2009\u00b1\u200966.63 m vs. \u221217.34\u2009\u00b1\u200952.8 m). Target lobe volume reduction at 3 months was \u22121,195\u2009\u00b1\u2009683 ml (P\u2009&amp;lt;\u20090.0001). Of the EBV subjects, 97.2% achieved volume reduction in the target lobe (P\u2009&amp;lt;\u20090.0001). Procedure-related pneumothoraces occurred in 11 subjects (25.6%). Five subjects required removal\/replacement of one or more valves. One subject experienced two valve migration events requiring removal\/replacement of valves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EBV in patients with homogeneous emphysema without collateral ventilation results in clinically meaningful benefits of improved lung function, exercise tolerance, and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201607-1383oc","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T14:34:19Z","timestamp":1472654059000},"page":"1073-1082","source":"Crossref","is-referenced-by-count":302,"title":["Endobronchial Valve Therapy in Patients with Homogeneous Emphysema: Results from the IMPACT Study"],"prefix":"10.1093","volume":"194","author":[{"given":"Arschang","family":"Valipour","sequence":"first","affiliation":[{"name":"Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Otto Wagner Spital, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk-Jan","family":"Slebos","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, University of Groningen, and University Medical Center Groningen, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Herth","sequence":"additional","affiliation":[{"name":"Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg and Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaid","family":"Darwiche","sequence":"additional","affiliation":[{"name":"Department of Interventional Pneumology, Ruhrlandklinik, West German Lung Center, University Clinic Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Allergology and Sleep Medicine, General Hospital Nuernberg, and Paracelsus Medical University, Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim H.","family":"Ficker","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Allergology and Sleep Medicine, General Hospital Nuernberg, and Paracelsus Medical University, Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Petermann","sequence":"additional","affiliation":[{"name":"Lungenabteilung, Thoraxzentrum Hamburg, Asklepios Klinik, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf-Harto","family":"Hubner","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Campus Virchow-Klinikum, Berlin, 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