{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:00:33Z","timestamp":1774076433243,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"DOI":"10.1164\/rccm.201611-2274le","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T10:55:11Z","timestamp":1498820111000},"page":"107-109","source":"Crossref","is-referenced-by-count":12,"title":["Increased IgE+ B Cells in Sputum, but Not Blood, Bone Marrow, or Tonsils, after Inhaled Allergen Challenge in Subjects with Asthma"],"prefix":"10.1093","volume":"196","author":[{"given":"John-Paul","family":"Oliveria","sequence":"first","affiliation":[{"name":"McMaster University, Hamilton, Ontario, Canada, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany M.","family":"Salter","sequence":"additional","affiliation":[{"name":"McMaster University, Hamilton, Ontario, Canada, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"MacLean","sequence":"additional","affiliation":[{"name":"McMaster University, Hamilton, Ontario, Canada, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shweta","family":"Kotwal","sequence":"additional","affiliation":[{"name":"Genentech Incorporated, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Smith","sequence":"additional","affiliation":[{"name":"Genentech Incorporated, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Harris","sequence":"additional","affiliation":[{"name":"Genentech Incorporated, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heleen","family":"Scheerens","sequence":"additional","affiliation":[{"name":"Genentech Incorporated, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roma","family":"Sehmi","sequence":"additional","affiliation":[{"name":"McMaster University, Hamilton, Ontario, Canada, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6187-2385","authenticated-orcid":false,"given":"Gail M.","family":"Gauvreau","sequence":"additional","affiliation":[{"name":"McMaster University, Hamilton, Ontario, Canada, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,7,1]]},"reference":[{"key":"2026032023425702600_bib1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/all.12563","article-title":"IgE+ B cells are scarce, but allergen-specific B cells with a memory phenotype circulate in patients with allergic rhinitis","volume":"70","author":"Wong","year":"2015","journal-title":"Allergy"},{"key":"2026032023425702600_bib2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1164\/ajrccm.165.1.2010112","article-title":"Increases in allergen-specific IgE in BAL after segmental allergen challenge in atopic asthmatics","volume":"165","author":"Wilson","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032023425702600_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1398-9995.2011.02722.x","article-title":"Increase in allergen-specific IgE and ex vivo Th2 responses after a single bronchial challenge with house dust mite in allergic asthmatics","volume":"67","author":"van de Pol","year":"2012","journal-title":"Allergy"},{"key":"2026032023425702600_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1398-9995.2006.01305.x","article-title":"GINA guidelines on asthma and beyond","volume":"62","author":"Bousquet","year":"2007","journal-title":"Allergy"},{"key":"2026032023425702600_bib5","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1164\/ajrccm.160.2.9809130","article-title":"Kinetics of allergen-induced airway eosinophilic cytokine production and airway inflammation","volume":"160","author":"Gauvreau","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032023425702600_bib6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1164\/rccm.201508-1623OC","article-title":"Allergen-induced changes in bone marrow and airway dendritic cells in subjects with asthma","volume":"194","author":"El-Gammal","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032023425702600_bib7","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jaci.2009.06.047","article-title":"Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge","volume":"124","author":"Luger","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"2026032023425702600_bib8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.coi.2014.08.001","article-title":"Targeting IgE production in mice and humans","volume":"31","author":"Wu","year":"2014","journal-title":"Curr Opin Immunol"},{"key":"2026032023425702600_bib9","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/all.12679","article-title":"Intrinsic properties of germinal center\u2013derived B cells promote their enhanced class switching to IgE","volume":"70","author":"Ramadani","year":"2015","journal-title":"Allergy"},{"key":"2026032023425702600_bib10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nri844","article-title":"BAFF: a fundamental survival factor for B cells","volume":"2","author":"Mackay","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"2026032023425702600_bib11","doi-asserted-by":"crossref","first-page":"e0161161","DOI":"10.1371\/journal.pone.0161161","article-title":"Precursor B cells increase in the lung during airway allergic inflammation: a role for B cell\u2013activating factor","volume":"11","author":"Samitas","year":"2016","journal-title":"PLoS One"},{"key":"2026032023425702600_bib12","doi-asserted-by":"crossref","first-page":"7164","DOI":"10.4049\/jimmunol.177.10.7164","article-title":"Airway epithelial cells produce B cell\u2013activating factor of TNF family by an IFN-\u03b2\u2013dependent mechanism","volume":"177","author":"Kato","year":"2006","journal-title":"J Immunol"},{"key":"2026032023425702600_bib13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/all.12911","article-title":"Ontogeny of human IgE-expressing B cells and plasma cells","volume":"72","author":"Ramadani","year":"2017","journal-title":"Allergy"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/196\/1\/107\/67124523\/ajrccm_196_1_107.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/196\/1\/107\/67124523\/ajrccm_196_1_107.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:43:26Z","timestamp":1774064606000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/196\/1\/107\/8498904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,7,1]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201611-2274le","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,7,1]]}}}