{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:18:52Z","timestamp":1793146732297,"version":"4.5.0"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Asthma is associated with increased lung IgE production, but whether the secretory IgA system is affected in this disease remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We explored mucosal IgA transport in human asthma and its potential regulation by T-helper cell type 2 inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Bronchial biopsies from asthma and control subjects were assayed for bronchial epithelial polymeric immunoglobulin receptor (pIgR) expression and correlated to T-helper cell type 2 biomarkers. Bronchial epithelium reconstituted in vitro from these subjects, on culture in air\u2013liquid interface, was assayed for pIgR expression and regulation by IL-4\/IL-13.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Downregulation of pIgR protein was observed in the bronchial epithelium from patients with asthma (P\u2009=\u20090.0002 vs. control subjects). This epithelial defect was not observed ex vivo in the cultured epithelium from patients with asthma. Exogenous IL-13 and IL-4 could inhibit pIgR expression and IgA transcytosis. Mechanistic experiments showed that autocrine transforming growth factor-\u03b2 mediates the IL-4\/IL-13 effect on the pIgR, with a partial contribution of upregulated transforming growth factor-\u03b1\/epidermal growth factor receptor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study shows impaired bronchial epithelial pIgR expression in asthma, presumably affecting secretory IgA\u2013mediated frontline defense as a result of type 2 immune activation of the transforming growth factor pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201703-0561oc","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T11:56:07Z","timestamp":1523620567000},"page":"1396-1409","source":"Crossref","is-referenced-by-count":55,"title":["Bronchial Epithelial IgA Secretion Is Impaired in Asthma. Role of IL-4\/IL-13"],"prefix":"10.1093","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-0984","authenticated-orcid":false,"given":"Maha Zohra","family":"Ladjemi","sequence":"first","affiliation":[{"name":"P\u00f4le de Pneumologie, ORL, et Dermatologie and"},{"name":"Institute for Walloon Excellence in Lifesciences and Biotechnology, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Gras","sequence":"additional","affiliation":[{"name":"INSERM U 1067, CNRS UMR 7333, Universit\u00e9 Aix-Marseille, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Dupasquier","sequence":"additional","affiliation":[{"name":"P\u00f4le de Pneumologie, ORL, et Dermatologie and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Detry","sequence":"additional","affiliation":[{"name":"P\u00f4le de Pneumologie, ORL, et Dermatologie 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