{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:00:21Z","timestamp":1777658421851,"version":"3.51.4"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,15]]},"DOI":"10.1164\/rccm.201704-0759ed","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T11:16:17Z","timestamp":1502795777000},"page":"411-413","source":"Crossref","is-referenced-by-count":1,"title":["A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE?"],"prefix":"10.1093","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3084-3071","authenticated-orcid":false,"given":"Adrienne G.","family":"Randolph","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Anaesthesia, and"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,8,15]]},"reference":[{"key":"2026032023444359300_bib1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1097\/PCC.0000000000000225","article-title":"Pediatric severe sepsis in U.S. children\u2019s hospitals","volume":"15","author":"Balamuth","year":"2014","journal-title":"Pediatr Crit Care Med"},{"key":"2026032023444359300_bib2","doi-asserted-by":"crossref","first-page":"R174","DOI":"10.1186\/cc11652","article-title":"The pediatric sepsis biomarker risk model","volume":"16","author":"Wong","year":"2012","journal-title":"Crit Care"},{"key":"2026032023444359300_bib3","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1164\/rccm.201701-0066OC","article-title":"Improved risk stratification in pediatric septic shock using both protein and mRNA biomarkers: PERSEVERE-XP","volume":"196","author":"Wong","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032023444359300_bib4","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/00003246-199605000-00004","article-title":"PRISM III: an updated Pediatric Risk of Mortality score","volume":"24","author":"Pollack","year":"1996","journal-title":"Crit Care Med"},{"key":"2026032023444359300_bib5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/COH.0b013e32833ed177","article-title":"What are biomarkers?","volume":"5","author":"Strimbu","year":"2010","journal-title":"Curr Opin HIV AIDS"},{"key":"2026032023444359300_bib6","doi-asserted-by":"crossref","first-page":"e86242","DOI":"10.1371\/journal.pone.0086242","article-title":"Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model","volume":"9","author":"Wong","year":"2014","journal-title":"PLoS One"},{"key":"2026032023444359300_bib7","doi-asserted-by":"crossref","first-page":"e92121","DOI":"10.1371\/journal.pone.0092121","article-title":"The temporal version of the pediatric sepsis biomarker risk model","volume":"9","author":"Wong","year":"2014","journal-title":"PLoS One"},{"key":"2026032023444359300_bib8","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1097\/CCM.0000000000001852","article-title":"Pediatric sepsis biomarker risk model-II: redefining the pediatric sepsis biomarker risk model with septic shock phenotype","volume":"44","author":"Wong","year":"2016","journal-title":"Crit Care Med"},{"key":"2026032023444359300_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1517\/17530059.2012.718329","article-title":"Challenges in biomarker discovery: combining expert insights with statistical analysis of complex omics data","volume":"7","author":"McDermott","year":"2013","journal-title":"Expert Opin Med Diagn"},{"key":"2026032023444359300_bib10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1067\/mcp.2001.113989","article-title":"Biomarkers and surrogate endpoints: preferred definitions and conceptual framework","volume":"69","author":"Biomarkers Definitions Working Group.","year":"2001","journal-title":"Clin Pharmacol Ther"},{"key":"2026032023444359300_bib11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/01.PCC.0000149131.72248.E6","article-title":"International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics","volume":"6","author":"Goldstein","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"2026032023444359300_bib12","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"2026032023444359300_bib13","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1097\/CCM.0b013e31828a2bbd","article-title":"Groupe Francophone de Reanimation et d\u2019Urgences Pediatriques. PELOD-2: an update of the Pediatric Logistic Organ Dysfunction score","volume":"41","author":"Leteurtre","year":"2013","journal-title":"Crit Care Med"},{"key":"2026032023444359300_bib14","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S2213-2600(14)70097-9","article-title":"Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials","volume":"2","author":"Calfee","year":"2014","journal-title":"Lancet Respir Med"},{"key":"2026032023444359300_bib15","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1164\/rccm.201606-1225OC","article-title":"The host response in patients with sepsis developing intensive care unit\u2013acquired secondary infections","volume":"196","author":"van Vught","journal-title":"Am J Respir Crit Care Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/196\/4\/411\/67125587\/ajrccm_196_4_411.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/196\/4\/411\/67125587\/ajrccm_196_4_411.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:45:17Z","timestamp":1774064717000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/196\/4\/411\/8499048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,8,15]]},"published-print":{"date-parts":[[2017,8,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201704-0759ed","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,8]]},"published":{"date-parts":[[2017,8]]}}}