{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:17:56Z","timestamp":1790162276806,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>In addition to their well-known function as antibody-producing cells, B lymphocytes can markedly influence the course of infectious or noninfectious diseases via antibody-independent mechanisms. In tuberculosis (TB), B cells accumulate in lungs, yet their functional contribution to the host response remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To document the role of B cells in TB in an unbiased manner.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We generated the transcriptome of B cells isolated from Mycobacterium tuberculosis (Mtb)-infected mice and validated the identified key pathways using in vitro and in vivo assays. The obtained data were substantiated using B cells from pleural effusion of patients with TB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>B cells isolated from Mtb-infected mice displayed a STAT1 (signal transducer and activator of transcription 1)-centered signature, suggesting a role for IFNs in B-cell response to infection. B cells stimulated in vitro with Mtb produced type I IFN, via a mechanism involving the innate sensor STING (stimulator of interferon genes), and antagonized by MyD88 (myeloid differentiation primary response 88) signaling. In vivo, B cells expressed type I IFN in the lungs of Mtb-infected mice and, of clinical relevance, in pleural fluid from patients with TB. Type I IFN expression by B cells induced an altered polarization of macrophages toward a regulatory\/antiinflammatory profile in vitro. In vivo, increased provision of type I IFN by B cells in a murine model of B cell\u2013restricted Myd88 deficiency correlated with an enhanced accumulation of regulatory\/antiinflammatory macrophages in Mtb-infected lungs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Type I IFN produced by Mtb-stimulated B cells favors macrophage polarization toward a regulatory\/antiinflammatory phenotype during Mtb infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201707-1475oc","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T12:32:45Z","timestamp":1511267565000},"page":"801-813","source":"Crossref","is-referenced-by-count":81,"title":["B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis"],"prefix":"10.1093","volume":"197","author":[{"given":"Alan","family":"B\u00e9nard","sequence":"first","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale, Universit\u00e9 de Toulouse, Centre National de la Recherche Scientifique (CNRS), Universit\u00e9 Paul Sabatier, Toulouse, France"},{"name":"International Associated Laboratory CNRS \u201cIM-TB\/HIV (Immunometabolism and Macrophages in Tuberculosis\/Human Immunodeficiency Virus-1 Co-infection),\u201d Toulouse, France, and Buenos Aires, Argentina"},{"name":"Department of Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imme","family":"Sakwa","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Schierloh","sequence":"additional","affiliation":[{"name":"International Associated Laboratory CNRS \u201cIM-TB\/HIV (Immunometabolism and Macrophages in Tuberculosis\/Human Immunodeficiency Virus-1 Co-infection),\u201d Toulouse, France, and Buenos Aires, Argentina"},{"name":"Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Academia Nacional de Medicina, Pacheco de Melo, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Colom","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale, Universit\u00e9 de Toulouse, Centre National de la Recherche Scientifique (CNRS), Universit\u00e9 Paul Sabatier, Toulouse, France"},{"name":"International Associated Laboratory CNRS \u201cIM-TB\/HIV (Immunometabolism and Macrophages in Tuberculosis\/Human Immunodeficiency Virus-1 Co-infection),\u201d Toulouse, France, and Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Mercier","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale, Universit\u00e9 de Toulouse, Centre National de la Recherche Scientifique (CNRS), Universit\u00e9 Paul Sabatier, Toulouse, France"},{"name":"International Associated Laboratory CNRS \u201cIM-TB\/HIV (Immunometabolism and Macrophages in Tuberculosis\/Human Immunodeficiency Virus-1 Co-infection),\u201d Toulouse, France, and Buenos Aires, Argentina"},{"name":"Laboratoire d\u2019Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, Universit\u00e9 de Toulouse, CNRS, Institut National de la Recherche Agronomique (INRA), Institut National des Sciences Appliqu\u00e9es, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Tailleux","sequence":"additional","affiliation":[{"name":"Unit of Mycobacterial Genetics and"},{"name":"Unit for Integrated Mycobacterial Pathogenomics, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Jouneau","sequence":"additional","affiliation":[{"name":"Virologie et Immunologie Mol\u00e9culaires, INRA, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Boudinot","sequence":"additional","affiliation":[{"name":"Virologie et Immunologie Mol\u00e9culaires, INRA, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talal","family":"Al-Saati","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM)\/Universit\u00e9 Paul Sabatier\/\u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse\/Centre R\u00e9gional d\u2019Exploration Fonctionnelle et Ressources Exp\u00e9rimentales, Service d\u2019Histopathologie, Centre Hospitalier Universitaire, Purpan, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Lang","sequence":"additional","affiliation":[{"name":"Institute of Clinical Microbiology, Immunology, and Hygiene, University Hospital Erlangen, Friedrich-Alexander University Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Rehwinkel","sequence":"additional","affiliation":[{"name":"Radcliffe Department of Medicine, Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre G.","family":"Loxton","sequence":"additional","affiliation":[{"name":"South African Medical Research Council Centre for Tuberculosis Research, Department of Science and Technology\/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan H. E.","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max Planck Institute of Infection Biology, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Anton-Leberre","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, Universit\u00e9 de Toulouse, CNRS, Institut National de la Recherche Agronomique (INRA), Institut National des Sciences Appliqu\u00e9es, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"O\u2019Garra","sequence":"additional","affiliation":[{"name":"Division of Immunoregulation, Medical Research Council, National Institute for Medical Research, London, United Kingdom"},{"name":"National Heart and Lung Institute, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Del Carmen","family":"Sasiain","sequence":"additional","affiliation":[{"name":"International Associated Laboratory CNRS \u201cIM-TB\/HIV (Immunometabolism and Macrophages in Tuberculosis\/Human Immunodeficiency Virus-1 Co-infection),\u201d Toulouse, France, and Buenos Aires, Argentina"},{"name":"Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Academia Nacional de Medicina, Pacheco de Melo, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Gicquel","sequence":"additional","affiliation":[{"name":"Virologie et Immunologie Mol\u00e9culaires, INRA, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Fillatreau","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Berlin, Germany"},{"name":"Institut Necker-Enfants Malades, INSERM U1151-CNRS Unit\u00e9 Mixte de Recherche 8253, Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France; and"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants Malades, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Neyrolles","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale, Universit\u00e9 de Toulouse, Centre National de la Recherche Scientifique (CNRS), Universit\u00e9 Paul Sabatier, Toulouse, France"},{"name":"International Associated Laboratory CNRS \u201cIM-TB\/HIV (Immunometabolism and Macrophages in Tuberculosis\/Human Immunodeficiency Virus-1 Co-infection),\u201d Toulouse, France, and Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Hudrisier","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale, Universit\u00e9 de Toulouse, Centre National de la Recherche Scientifique (CNRS), Universit\u00e9 Paul Sabatier, Toulouse, France"},{"name":"International Associated Laboratory CNRS \u201cIM-TB\/HIV (Immunometabolism and Macrophages in Tuberculosis\/Human Immunodeficiency Virus-1 Co-infection),\u201d Toulouse, France, and Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,3,15]]},"reference":[{"key":"2026032023164684400_bib1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1086\/508894","article-title":"Mycobacterium tuberculosis triggers formation of lymphoid structure in murine lungs","volume":"195","author":"Kahnert","year":"2007","journal-title":"J Infect Dis"},{"key":"2026032023164684400_bib2","doi-asserted-by":"crossref","first-page":"7222","DOI":"10.4049\/jimmunol.178.11.7222","article-title":"B cells moderate inflammatory progression and enhance bacterial containment upon pulmonary challenge with Mycobacterium tuberculosis","volume":"178","author":"Maglione","year":"2007","journal-title":"J Immunol"},{"key":"2026032023164684400_bib3","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1462-5822.2005.00612.x","article-title":"Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension","volume":"8","author":"Tsai","year":"2006","journal-title":"Cell Microbiol"},{"key":"2026032023164684400_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/path.1628","article-title":"Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lung","volume":"204","author":"Ulrichs","year":"2004","journal-title":"J Pathol"},{"key":"2026032023164684400_bib5","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.smim.2014.10.005","article-title":"The role of B cells and humoral immunity in Mycobacterium tuberculosis infection","volume":"26","author":"Chan","year":"2014","journal-title":"Semin Immunol"},{"key":"2026032023164684400_bib6","doi-asserted-by":"crossref","first-page":"e1003472","DOI":"10.1371\/journal.ppat.1003472","article-title":"B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response","volume":"9","author":"Kozakiewicz","year":"2013","journal-title":"PLoS Pathog"},{"key":"2026032023164684400_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-1-4614-6111-1_12","article-title":"The role of B cells and humoral immunity in Mycobacterium tuberculosis infection","volume":"783","author":"Kozakiewicz","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"2026032023164684400_bib8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0962-8479(97)90006-X","article-title":"Mycobacterium tuberculosis aerogenic rechallenge infections in B cell-deficient mice","volume":"78","author":"Johnson","year":"1997","journal-title":"Tuber Lung Dis"},{"key":"2026032023164684400_bib9","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cell.2016.08.072","article-title":"A functional role for antibodies in tuberculosis","volume":"167","author":"Lu","year":"2016","journal-title":"Cell"},{"key":"2026032023164684400_bib10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1056\/NEJMcibr1613268","article-title":"Antibodies to Mycobacterium tuberculosis","volume":"376","author":"Casadevall","year":"2017","journal-title":"N Engl J Med"},{"key":"2026032023164684400_bib11","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.4049\/jimmunol.0902011","article-title":"B cells delay neutrophil migration toward the site of stimulus: tardiness critical for effective bacillus Calmette-Gu\u00e9rin vaccination against tuberculosis infection in mice","volume":"184","author":"Kondratieva","year":"2010","journal-title":"J Immunol"},{"key":"2026032023164684400_bib12","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0531-5565(00)00257-6","article-title":"The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4","volume":"36","author":"Turner","year":"2001","journal-title":"Exp Gerontol"},{"key":"2026032023164684400_bib13","first-page":"164","article-title":"Infections and biological therapy in patients with rheumatic diseases","volume":"18","author":"Atzeni","year":"2016","journal-title":"Isr Med Assoc J"},{"key":"2026032023164684400_bib14","doi-asserted-by":"crossref","first-page":"e0153217","DOI":"10.1371\/journal.pone.0153217","article-title":"Different risk of tuberculosis and efficacy of isoniazid prophylaxis in rheumatoid arthritis patients with biologic therapy: a nationwide retrospective cohort study in Taiwan","volume":"11","author":"Liao","year":"2016","journal-title":"PLoS One"},{"key":"2026032023164684400_bib15","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1128\/IAI.00083-16","article-title":"Effects of B cell depletion on early Mycobacterium tuberculosis infection in cynomolgus macaques","volume":"84","author":"Phuah","year":"2016","journal-title":"Infect Immun"},{"key":"2026032023164684400_bib16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-065X.2010.00991.x","article-title":"Novel regulatory functions for Toll-like receptor-activated B cells during intracellular bacterial infection","volume":"240","author":"Fillatreau","year":"2011","journal-title":"Immunol Rev"},{"key":"2026032023164684400_bib17","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.immuni.2010.10.016","article-title":"Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection","volume":"33","author":"Neves","year":"2010","journal-title":"Immunity"},{"key":"2026032023164684400_bib18","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature12979","article-title":"IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases","volume":"507","author":"Shen","year":"2014","journal-title":"Nature"},{"key":"2026032023164684400_bib19","doi-asserted-by":"crossref","first-page":"ii80","DOI":"10.1136\/annrheumdis-2012-202253","article-title":"Cytokine-producing B cells as regulators of pathogenic and protective immune responses","volume":"72","author":"Fillatreau","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"2026032023164684400_bib20","doi-asserted-by":"crossref","first-page":"D1040","DOI":"10.1093\/nar\/gks1215","article-title":"Interferome v2.0: an updated database of annotated interferon-regulated genes","volume":"41","author":"Rusinova","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2026032023164684400_bib21","doi-asserted-by":"crossref","first-page":"e1003989","DOI":"10.1371\/journal.ppat.1003989","article-title":"Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS\/STING-mediated cytosolic DNA-sensing pathway","volume":"10","author":"Dai","year":"2014","journal-title":"PLoS Pathog"},{"key":"2026032023164684400_bib22","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nm.3813","article-title":"A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis","volume":"21","author":"Dey","year":"2015","journal-title":"Nat Med"},{"key":"2026032023164684400_bib23","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.4049\/jimmunol.1100088","article-title":"MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP","volume":"187","author":"Jin","year":"2011","journal-title":"J Immunol"},{"key":"2026032023164684400_bib24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/mmi.12641","article-title":"Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) in Mycobacterium tuberculosis leads to reduced virulence in a mouse model of infection","volume":"93","author":"Yang","year":"2014","journal-title":"Mol Microbiol"},{"key":"2026032023164684400_bib25","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.4049\/jimmunol.0904013","article-title":"Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate","volume":"184","author":"Schoenen","year":"2010","journal-title":"J Immunol"},{"key":"2026032023164684400_bib26","doi-asserted-by":"crossref","first-page":"e6329","DOI":"10.1371\/journal.pone.0006329","article-title":"TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms","volume":"4","author":"Benson","year":"2009","journal-title":"PLoS One"},{"key":"2026032023164684400_bib27","doi-asserted-by":"crossref","first-page":"6272","DOI":"10.4049\/jimmunol.172.10.6272","article-title":"Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms","volume":"172","author":"Fortune","year":"2004","journal-title":"J Immunol"},{"key":"2026032023164684400_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature13489","article-title":"Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk","volume":"511","author":"Mayer-Barber","year":"2014","journal-title":"Nature"},{"key":"2026032023164684400_bib29","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nature09247","article-title":"An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis","volume":"466","author":"Berry","year":"2010","journal-title":"Nature"},{"key":"2026032023164684400_bib30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/imr.12269","article-title":"The human immune response to tuberculosis and its treatment: a view from the blood","volume":"264","author":"Cliff","year":"2015","journal-title":"Immunol Rev"},{"key":"2026032023164684400_bib31","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1128\/IAI.01011-07","article-title":"Tumor necrosis factor blockade in chronic murine tuberculosis enhances granulomatous inflammation and disorganizes granulomas in the lungs","volume":"76","author":"Chakravarty","year":"2008","journal-title":"Infect Immun"},{"key":"2026032023164684400_bib32","doi-asserted-by":"crossref","first-page":"310ra166","DOI":"10.1126\/scitranslmed.aab4176","article-title":"Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy","volume":"7","author":"Li","year":"2015","journal-title":"Sci Transl Med"},{"key":"2026032023164684400_bib33","doi-asserted-by":"crossref","first-page":"e61681","DOI":"10.1371\/journal.pone.0061681","article-title":"Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse","volume":"8","author":"Torrado","year":"2013","journal-title":"PLoS One"},{"key":"2026032023164684400_bib34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1084\/jem.20021750","article-title":"T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation","volume":"197","author":"Fillatreau","year":"2003","journal-title":"J Exp Med"},{"key":"2026032023164684400_bib35","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/ni833","article-title":"B cells regulate autoimmunity by provision of IL-10","volume":"3","author":"Fillatreau","year":"2002","journal-title":"Nat Immunol"},{"key":"2026032023164684400_bib36","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1172\/JCI40817","article-title":"Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte\/macrophage population","volume":"120","author":"Antonelli","year":"2010","journal-title":"J Clin Invest"},{"key":"2026032023164684400_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep"},{"key":"2026032023164684400_bib38","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"2026032023164684400_bib39","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1084\/jem.20161451","article-title":"Detection of interferon alpha protein reveals differential levels and cellular sources in disease","volume":"214","author":"Rodero","year":"2017","journal-title":"J Exp Med"},{"key":"2026032023164684400_bib40","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1002\/eji.201344219","article-title":"Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics","volume":"44","author":"Dorhoi","year":"2014","journal-title":"Eur J Immunol"},{"key":"2026032023164684400_bib41","doi-asserted-by":"crossref","first-page":"e1005687","DOI":"10.1371\/journal.ppat.1005687","article-title":"Patients with tuberculosis have a dysfunctional circulating B-cell compartment, which normalizes following successful treatment","volume":"12","author":"Joosten","year":"2016","journal-title":"PLoS Pathog"},{"key":"2026032023164684400_bib42","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1002\/eji.200940288","article-title":"Macrophage polarization to a unique phenotype driven by B cells","volume":"40","author":"Wong","year":"2010","journal-title":"Eur J Immunol"},{"key":"2026032023164684400_bib43","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.4049\/jimmunol.1401088","article-title":"Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-\u03b3 for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages","volume":"193","author":"McNab","year":"2014","journal-title":"J Immunol"},{"key":"2026032023164684400_bib44","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev-immunol-032712-095939","article-title":"The immune response in tuberculosis","volume":"31","author":"O\u2019Garra","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"2026032023164684400_bib45","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1089\/jir.2005.25.694","article-title":"Hypervirulent M. tuberculosis W\/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway","volume":"25","author":"Manca","year":"2005","journal-title":"J Interferon Cytokine Res"},{"key":"2026032023164684400_bib46","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4049\/jimmunol.179.1.522","article-title":"The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation","volume":"179","author":"Ordway","year":"2007","journal-title":"J Immunol"},{"key":"2026032023164684400_bib47","doi-asserted-by":"crossref","first-page":"7853","DOI":"10.1073\/pnas.1121072109","article-title":"Common patterns and disease-related signatures in tuberculosis and sarcoidosis","volume":"109","author":"Maertzdorf","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026032023164684400_bib48","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1164\/rccm.201405-0828OC","article-title":"Lung-residing myeloid-derived suppressors display dual functionality in murine pulmonary tuberculosis","volume":"190","author":"Knaul","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032023164684400_bib49","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.4049\/jimmunol.180.7.4763","article-title":"TLR-activated B cells suppress T cell-mediated autoimmunity","volume":"180","author":"Lampropoulou","year":"2008","journal-title":"J Immunol"},{"key":"2026032023164684400_bib50","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3389\/fimmu.2014.00526","article-title":"Harnessing mechanistic knowledge on beneficial versus deleterious IFN-I effects to design innovative immunotherapies targeting cytokine activity to specific cell types","volume":"5","author":"Tomasello","year":"2014","journal-title":"Front Immunol"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/197\/6\/801\/67122779\/ajrccm_197_6_801.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/197\/6\/801\/67122779\/ajrccm_197_6_801.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:17:01Z","timestamp":1774063021000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/197\/6\/801\/8498630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":50,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,3,15]]},"published-print":{"date-parts":[[2018,3,15]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201707-1475oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,3]]},"published":{"date-parts":[[2018,3]]}}}