{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:47:10Z","timestamp":1793386030021,"version":"4.5.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 81500009"],"award-info":[{"award-number":["NSFC 81500009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570092"],"award-info":[{"award-number":["81570092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Cough hypersensitivity syndrome is often triggered by a viral infection. The viral infection might trigger cough hypersensitivity via increasing the release of IFN-\u03b3 from T lymphocytes in the lung.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate effects of IFN-\u03b3 on the vagal sensory neurons and the cough reflex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Effects of IFN-\u03b3 on the cough reflex were investigated in guinea pigs. Cellular immunofluorescence imaging, calcium imaging, and patch clamp techniques were used to study effects of IFN-\u03b3 in primary cultured rat vagal sensory neurons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Intratracheal instillation of IFN-\u03b3 enhanced the cough response to citric acid in vivo. IFN-\u03b3 significantly increased levels of phosphorylated signal transducer and activator of transcription-1 but not phosphorylated transient receptor potential vanilloid 1 in vitro. Not only did IFN-\u03b3 enhance the response of neurons to capsaicin and electric stimulation, but also it directly induced Ca2+ influx, membrane depolarization, and action potentials in neurons via the Janus kinase, protein kinase A, and \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid pathways. However, IFN-\u03b3 did not elicit Ca2+ release from the endoplasmic reticulum via the phospholipase C pathway. Although IFN-\u03b3\u2013induced action potentials were suppressed by Ca2+ influx inhibitors, IFN-\u03b3\u2013induced Ca2+ influx was not altered by an inhibitor of rapid sodium channels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The membrane potential in vagal sensory neurons may be depolarized by IFN-\u03b3\u2013induced Ca2+ influx. The depolarization of membrane potentials may enhance the cough reflex sensitivity and cause action potentials. IFN-\u03b3 may be a new target for treating cough hypersensitivity syndrome and postviral cough.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201709-1813oc","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T15:19:10Z","timestamp":1524151150000},"page":"868-879","source":"Crossref","is-referenced-by-count":52,"title":["IFN-\u03b3 Enhances the Cough Reflex Sensitivity via Calcium Influx in Vagal Sensory Neurons"],"prefix":"10.1093","volume":"198","author":[{"given":"Zheng","family":"Deng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"},{"name":"School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of 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