{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:58:02Z","timestamp":1787018282490,"version":"build-2736575974"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Childhood sleep-disordered breathing ranges in severity from primary snoring to obstructive sleep apnea and is associated with behavioral and neurocognitive deficits. It remains unknown why children with primary snoring, who do not experience peripheral oxygen desaturation or sleep fragmentation, experience similar daytime deficits as those with obstructive sleep apnea or why effects are age-dependent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine cerebral tissue oxygenation and oxygen extraction as an explanation for daytime deficits in children with primary snoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children referred for suspected sleep-disordered breathing and nonsnoring control subjects underwent overnight polysomnography with near-infrared spectroscopy. Children were categorized into 3- to 6-year (n\u2009=\u200987) and 7- to 12-year (n\u2009=\u200972) old groups, and according to the obstructive apnea\u2013hypopnea index into primary snoring (\u22641 event\/h), mild (&amp;gt;1\u20135 events\/h), and moderate\/severe obstructive sleep apnea (&amp;gt;5 events\/h). Cognitive and behavioral performance were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>In the 3- to 6-year group, there were no differences in cerebral oxygenation or oxygen extraction between severity groups. In the 7- to 12-year group, cerebral oxygenation was significantly lower, although these differences were small, in control subjects versus primary snoring during quiet wakefulness before sleep onset, N1, and REM. Oxygen extraction was significantly higher in control subjects versus primary snoring during N1 sleep, with no differences between primary snoring and obstructive sleep apnea groups. Cerebral oxygenation was not associated with cognitive performance in either age group or behavior in the 3- to 6-year group; however, it was associated with behavior in the school-aged children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with sleep-disordered breathing are able to maintain cerebral oxygenation, and the small changes observed are not related to cognitive deficits. However, in older children these differences were related to behavioral measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201709-1825oc","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T16:12:03Z","timestamp":1516378323000},"page":"1468-1477","source":"Crossref","is-referenced-by-count":37,"title":["Age Effects on Cerebral Oxygenation and Behavior in Children with Sleep-disordered Breathing"],"prefix":"10.1093","volume":"197","author":[{"given":"Knarik","family":"Tamanyan","sequence":"first","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia"},{"name":"Department of Paediatrics, Monash University, Melbourne, Victoria, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Walter","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia"},{"name":"Department of Paediatrics, Monash University, Melbourne, Victoria, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidan","family":"Weichard","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia"},{"name":"Department of Paediatrics, Monash University, Melbourne, Victoria, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot J.","family":"Davey","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia"},{"name":"Department of Paediatrics, Monash University, Melbourne, Victoria, Australia; and"},{"name":"Melbourne Children\u2019s Sleep Centre, Monash Children\u2019s Hospital, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian M.","family":"Nixon","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia"},{"name":"Department of Paediatrics, Monash University, Melbourne, Victoria, Australia; and"},{"name":"Melbourne Children\u2019s Sleep Centre, Monash Children\u2019s Hospital, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah N.","family":"Biggs","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia"},{"name":"Department of Paediatrics, Monash University, Melbourne, Victoria, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary S. 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