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It represents a very important comorbidity that is associated with poor quality of life and reduced survival. It results from a complex combination of functional, metabolic, and anatomical alterations leading to suboptimal muscle work. Muscle atrophy, altered fiber type and metabolism, and chest wall remodeling, in the case of the respiratory muscles, are relevant etiological contributors to this process. Muscle dysfunction worsens during COPD exacerbations, rendering patients progressively less able to perform activities of daily living, and it is also associated with poor outcomes. Muscle recovery measures consisting of a combination of pulmonary rehabilitation, optimized nutrition, and other strategies are associated with better prognosis when administered in stable patients as well as after exacerbations. A deeper understanding of this process\u2019 pathophysiology and clinical relevance will facilitate the use of measures to alleviate its effects and potentially improve patients\u2019 outcomes. In this review, a general overview of skeletal muscle dysfunction in COPD is offered to highlight its relevance and magnitude to expert practitioners and scientists as well as to the average clinician dealing with patients with chronic respiratory diseases.<\/jats:p>","DOI":"10.1164\/rccm.201710-2140ci","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T17:24:48Z","timestamp":1521480288000},"page":"175-186","source":"Crossref","is-referenced-by-count":290,"title":["Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. What We Know and Can Do for Our Patients"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4714-2260","authenticated-orcid":false,"given":"Ariel","family":"Jaitovich","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine and"},{"name":"Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-3443","authenticated-orcid":false,"given":"Esther","family":"Barreiro","sequence":"additional","affiliation":[{"name":"Pulmonology Department-Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Research Group, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques-Hospital del Mar, Parc de Salut Mar, Health and Experimental Sciences Department, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, Barcelona, Spain; and"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,7,15]]},"reference":[{"key":"2026032023231220200_bib1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1164\/rccm.2107031","article-title":"Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease","volume":"166","author":"Marquis","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032023231220200_bib2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1183\/09031936.00170111","article-title":"Quadriceps wasting and physical inactivity in patients with COPD","volume":"40","author":"Shrikrishna","year":"2012","journal-title":"Eur Respir J"},{"key":"2026032023231220200_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/thx.2006.062026","article-title":"Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease","volume":"62","author":"Swallow","year":"2007","journal-title":"Thorax"},{"key":"2026032023231220200_bib4","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1164\/rccm.201209-1665OC","article-title":"Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease","volume":"187","author":"Vanfleteren","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032023231220200_bib5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0002-9343(68)90234-9","article-title":"Chronic obstructive bronchopulmonary disease. 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