{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:15:01Z","timestamp":1778285701813,"version":"3.51.4"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1164\/rccm.201802-0328rr","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T12:08:09Z","timestamp":1538568489000},"page":"110-112","source":"Crossref","is-referenced-by-count":7,"title":["Eosinophilic Chronic Obstructive Pulmonary Disease: Implications for Exacerbations, Readmissions, and Treatment"],"prefix":"10.1093","volume":"199","author":[{"given":"Mona T.","family":"Vashi","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care, Rush University Medical Center, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jansi L.","family":"Willoughby","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Rush University Medical Center, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Rush University Medical Center, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty T.","family":"Tran","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Rush University Medical Center, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,1,1]]},"reference":[{"key":"2026030321232018800_bib1","doi-asserted-by":"crossref","first-page":"1700853","DOI":"10.1183\/13993003.00853-2017","article-title":"Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort","volume":"50","author":"Kim","year":"2017","journal-title":"Eur Respir J"},{"key":"2026030321232018800_bib2","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1183\/09031936.00162414","article-title":"Eosinophilic inflammation in COPD: prevalence and clinical characteristics","volume":"44","author":"Singh","year":"2014","journal-title":"Eur Respir J"},{"key":"2026030321232018800_bib3","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1183\/09031936.00146306","article-title":"Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial","volume":"29","author":"Siva","year":"2007","journal-title":"Eur Respir J"},{"key":"2026030321232018800_bib4","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1164\/rccm.201104-0597OC","article-title":"Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers","volume":"184","author":"Bafadhel","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321232018800_bib5","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.chest.2016.10.003","article-title":"Eosinophils in COPD exacerbations are associated with increased readmissions","volume":"151","author":"Couillard","year":"2017","journal-title":"Chest"},{"key":"2026030321232018800_bib6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1164\/rccm.201502-0235LE","article-title":"Blood eosinophils: a biomarker of response to extrafine beclomethasone\/formoterol in chronic obstructive pulmonary disease","volume":"192","author":"Siddiqui","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030321232018800_bib7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S2213-2600(15)00106-X","article-title":"Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials","volume":"3","author":"Pascoe","year":"2015","journal-title":"Lancet Respir Med"},{"key":"2026030321232018800_bib8","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJM195110112451501","article-title":"Clinical studies on the activity of orally administered cortisone","volume":"245","author":"Thorn","year":"1951","journal-title":"N Engl J Med"},{"key":"2026030321232018800_bib9","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.chest.2016.01.026","article-title":"Blood eosinophils and outcomes in severe hospitalized exacerbations of COPD","volume":"150","author":"Bafadhel","year":"2016","journal-title":"Chest"},{"key":"2026030321232018800_bib10","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1056\/NEJMoa1708208","article-title":"Mepolizumab for eosinophilic chronic obstructive pulmonary disease","volume":"377","author":"Pavord","year":"2017","journal-title":"N Engl J Med"},{"key":"2026030321232018800_bib11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1183\/09031936.00062614","article-title":"Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis","volume":"44","author":"Bafadhel","year":"2014","journal-title":"Eur Respir J"},{"key":"2026030321232018800_bib12","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJMoa1403290","article-title":"Mepolizumab treatment in patients with severe eosinophilic asthma","volume":"371","author":"Ortega","year":"2014","journal-title":"N Engl J Med"},{"key":"2026030321232018800_bib13","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S2213-2600(17)30432-0","article-title":"Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort","volume":"5","author":"Hastie","year":"2017","journal-title":"Lancet Respir Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/199\/1\/110\/67113777\/ajrccm_199_1_110.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/199\/1\/110\/67113777\/ajrccm_199_1_110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T02:23:29Z","timestamp":1772591009000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/199\/1\/110\/8496709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,1]]},"published-print":{"date-parts":[[2019,1,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.201802-0328rr","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2019,1,1]]}}}