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Ezrin, a membrane-cytoskeleton protein, maintains cellular morphology and intercellular adhesion and protects the barrier function of epithelial cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To study the role of ezrin in bronchial epithelial cells injury and correlate its expression with asthma severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Levels of ezrin were measured in exhaled breath condensate (EBC) and serum in patients with asthma and BAL fluid (BALF) from a mouse model of asthma by ELISA. The regulation of IL-13 on ezrin protein levels was studied in primary bronchial epithelial cells. Ezrin knockdown using shRNA was studied in human bronchial epithelial 16HBE cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Ezrin levels were decreased in asthmatic EBC (92.7\u2009\u00b1\u200934.99 vs. 150.5\u2009\u00b1\u200910.22 pg\/ml, P\u2009&amp;lt;\u20090.0001) and serum (700.7\u2009\u00b1\u200955.59 vs. 279.2\u2009\u00b1\u200925.83 pg\/ml, P\u2009&amp;lt;\u20090.0001) compared with normal subjects. Levels were much lower in uncontrolled (P\u2009&amp;lt;\u20090.001) and partly controlled patients (P\u2009&amp;lt;\u20090.01) compared with well-controlled subjects. EBC and serum ezrin levels correlated with lung function in patients with asthma and serum ezrin levels were negatively correlated with serum IL-13 and periostin. IL-13\u2013induced downregulation of ezrin expression in primary bronchial epithelial cells was significantly attenuated by the Janus tyrosine kinase 2 inhibitor, TG101348. Ezrin knockdown changed 16HBE cell morphology, enlarged intercellular spaces, and increased their permeability. Ezrin expression was decreased in the lung tissue and BALF of \u201casthmatic\u201d mice and negatively correlated with BALF IL-13 level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ezrin downregulation is associated with IL-13\u2013induced epithelial damage and might be a potential biomarker of asthma control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.201802-0373oc","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T17:50:41Z","timestamp":1538761841000},"page":"496-507","source":"Crossref","is-referenced-by-count":51,"title":["Ezrin, a Membrane Cytoskeleton Cross-Linker Protein, as a Marker of Epithelial Damage in Asthma"],"prefix":"10.1093","volume":"199","author":[{"given":"Man","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, the First Affiliated 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Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuwedi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Nanjing Jiangning Hospital, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Nanjing First Hospital, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Nanjing First Hospital, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelios","family":"Pavlidis","sequence":"additional","affiliation":[{"name":"Data Science Institute, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter 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